Selective Photoinactivation of Methicillin‐Resistant <i>Staphylococcus aureus</i> by Highly Positively Charged Ru<sup>II</sup> Complexes

Yang, Feng; Sun, Weize; Wang, Xuesong; Zhou, Qianxiong

doi:10.1002/chem.201903923

Cited by 31 publications

(32 citation statements)

References 35 publications

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“…Unfortunately, no toxicological studies against human cell lines were reported [96]. More recently, Feng et al depicted a series of charged ruthenium complexes by using quaternary ammonium-modified bipyridine as ligand [95]. Their results indicated that the most highly charged complex (Figure 11, compound 16), bearing eight positive charges, exhibited the most potent aPDT activity against S. aureus, displaying 6-7 log reduction in bacterial viability (comparable to the traditional antibiotic vancomycin at equal concentrations) when irradiated with 470 nm light, while only minor activity was observed against Gram-negative bacterium E. coli, probably due to its dense and compact outer membrane which may hamper the photodegradation.…”

Section: Rutheniummentioning

confidence: 99%

New Antimicrobial Strategies Based on Metal Complexes

2020

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Traditional organic antimicrobials mainly act on specific biochemical processes such as replication, transcription and translation. However, the emergence and wide spread of microbial resistance is a growing threat for human beings. Therefore, it is highly necessary to design strategies for the development of new drugs in order to target multiple cellular processes that should improve their efficiency against several microorganisms, including bacteria, viruses or fungi. The present review is focused on recent advances and findings of new antimicrobial strategies based on metal complexes. Recent studies indicate that some metal ions cause different types of damages to microbial cells as a result of membrane degradation, protein dysfunction and oxidative stress. These unique modes of action, combined with the wide range of three-dimensional geometries that metal complexes can adopt, make them suitable for the development of new antimicrobial drugs.

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Section: Rutheniummentioning

confidence: 99%

New Antimicrobial Strategies Based on Metal Complexes

2020

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“…Very recently Feng et al. reported on highly positively charged ruthenium complexes that were effective at photoinactivating MRSA while possessing low toxicity and haemolytic properties [7b] …”

Section: Introductionmentioning

confidence: 99%

Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria

Frei

Amado

Cooper

et al. 2020

Chemistry A European J

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New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

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“…23 [Ru(bpy-TMEDA) 3 ] 8+ , 15 mM, achieved a 6.87 log 10 reduction of S. aureus in PBS buffer after 20 min of irradiation at 470 nm, 22 mW cm À2 for a total dose of 27 J cm À2 . 102 Whilst some of these transition metal photosensitisers are very efficient in killing of bacteria, all of the above systems have been studied in solution and therefore cannot be compared directly to 1-silica. Perhaps the closest comparison to 1-silica as a transition metal complex is [(4,7-diphenyl-1,10-phenanthroline) 3 Ru] 2+ , RDP 2+ , bound to porous silicone (pSil).…”

Section: Resultsmentioning

confidence: 99%