Colour M‐mode tissue Doppler imaging in healthy cats and cats with hypertrophic cardiomyopathy

Abstract

This study shows that hypertrophic cardiomyopathy cats have decreased myocardial velocity gradient during both diastole and systole and also altered myocardial motion during the two isovolumic periods. Myocardial velocity gradients recorded by colour M-mode tissue Doppler imaging can discriminate between the healthy and diseased myocardium.

Avaliação da função diastólica por meio de Doppler tecidual pulsado e colorido em gatos da raça Maine Coon geneticamente testados para a mutação no gene MyBPC-A31P

“…Pressões diastólicas aumentadas são necessárias devido à rigidez e à menor distensibilidade ventricular (Severino et al 2000, Chetboul et al 2006b, Gundler Tidholm & Haggstrõm 2008. O ventrículo esquerdo, mais rígido, requer pressões de enchimento maiores e, consequentemente, as pressões diastólicas atriais e ventriculares aumentam (Kato et al 2007, Ware 2007, Koffas et al 2008.…”

Feline hypertrophic cardiomyopathy: an echocardiographic approach

“…A study showed that the differences between normal and HCM cats were due to decreased early diastolic and systolic MVG and corresponding peak mean myocardial velocities were similar between the two groups (Koffas et al 2008). Another study using colour M-mode TDI in cats demonstrated that similar velocity patterns occur in the LVFW of cats when compared with measurements in humans, in which this part of the myocardium shows up alternately as red and blue as it moves towards and away from the transducer, respectively.…”

“…This movement involved the entire myocardium and was not confined to the endocardial region (Koffas et al 2003). These studies using 2D TDI colour and colour M-mode measurements showed that feline HCM was also associated with systolic myocardial dysfunction , Koffas et al 2008.…”

“…Finally, assessment of RV morphology and function is very difficult in M-mode studies (Ferasin 2009). Some clinical investigations of feline HCM have used an end-diastolic wall thickness equal to or exceeding 6.0 mm as the primary diagnostic criterion (Koffas et al 2008, Wess et al 2010. However, another study adopted 5.0 mm as a decision criterion (Brizard et al 2009) (figure 2).…”

“…Pulsed-wave and colour M-mode are TDI techniques that have been demonstrated to be sensitive tools to detect even mild forms of HCM, providing an early diagnosis of the disease (MacDonald et al 2006, Koffas et al 2006, Koffas et al 2008.…”