Colorimetric Detection of Glucose in Rat Brain Using Gold Nanoparticles

Jiang, Ying; Zhao, Hong; Lin, Yuqing; Zhu, Ning; Ma, Yurong; Mao, Lanqun

doi:10.1002/anie.201001057

Cited by 251 publications

(128 citation statements)

References 72 publications

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“…The target DNA hybridized with the fully complementary probe DNA on nanoparticles, which led to the large-scale aggregation of AuNPs, bringing a visible color transition from red to purple [32][33][34]. During the following decades, colorimetric detection based on AuNPs towards various targets has been extensively investigated including DNA [35][36][37], proteins [38][39][40], small organic molecules [41][42][43][44][45], and ions, such as mercury(II) [46][47][48], lead(II) [49,50], copper(II) [51,52], calcium(II) [53], uranium(II) [54] and nitrite [55].…”

Section: Introductionmentioning

confidence: 99%

Utilization of unmodified gold nanoparticles in colorimetric detection

Liu

Wang

et al. 2011

Sci. China Phys. Mech. Astron.

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This review begins with an overview of the appealing properties and various applications of gold nanoparticles, and briefly summarizes recent advances in using unmodified gold nanoparticles to detect different kinds of targets including nucleic acids, proteins, metal ions and small organic molecules. The key point to the unmodified gold nanoparticle-based visual detection assay is to control dispersion and aggregation of colloidal nanoparticles by targets of interest, which usually relies on affinities between gold nanoparticles and targets. The degree of dispersion or aggregation can be visualized through the change of the solution color or the precipitation of nanoparticles from the solution. Thus, the existence of the target molecules can be translated into optical signals and monitored by the naked eye conveniently. Finally, some future prospects of this research field are given. gold nanoparticles, colorimetric detection, biosensor

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Section: Introductionmentioning

confidence: 99%

Utilization of unmodified gold nanoparticles in colorimetric detection

Liu

Wang

et al. 2011

Sci. China Phys. Mech. Astron.

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show abstract

“…Although the Fe 2 þ -catalyzed Fenton reaction (Fe 2 þ plus H 2 O 2 under acidic conditions) has been successfully applied to facilitate the analyses of ROS-related substances (Jiang et al, 2010;Wei et al, 2014), its applicability has been hampered by the acidic reaction conditions, which would inactivate most biomolecules. In contrast, the Cu 2 þ -based Fenton-like reaction performs well under neutral sample conditions and can promote catalytic reactions in normal biological systems (Pham et al, 2013).…”

Section: Amplification Of Ros-mediated Fluorescence Intensitymentioning

confidence: 99%

Using copper ions to amplify ROS-mediated fluorescence for continuous online monitoring of extracellular glucose in living rat brain

Chen

Tseng

et al. 2015

Biosensors and Bioelectronics

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“…For example, a colorimetric assay for the detection of cerebral glucose was reported by coupling Au-NPs modified with adsorbed single-stranded DNA (ssDNA) (227). The hydroxyl radicals provided by the reaction between the enzymatically produced H 2 O 2 and Fe 2þ , both added to the solution containing the NPs, caused the cleavage of the adsorbed ssDNA.…”

Section: Metal Nanoparticles For Biomedical Applicationsmentioning

confidence: 99%