Colorimetric assay for the simultaneous detection of Hg<sup>2+</sup> and Ag<sup>+</sup> based on inhibiting the peroxidase-like activity of core–shell Au@Pt nanoparticles

Peng, Chifang; Zhang, Yingying; Wang, Liying; Jin, Zhengyu; Shao, Guang

doi:10.1039/c7ay01317e

Cited by 38 publications

(23 citation statements)

References 47 publications

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“…Most applications encompassed in this category are related to diagnostic tools to detect toxic contaminants in environmental waters. This mainly includes heavy metals [136,[176][177][178][179][180][181][182][183], pesticides [100,184,185] or micro-organisms [102,[186][187][188][189], for being the most common contaminants, but it could potentially include any others. Nonetheless, these are not the only examples of gold nanozyme applications in the environmental sector, especially since their catalytic activities started to be exploited for wastewater treatment to degrade or convert toxic molecules into innocuous products [190,191].…”

Section: Environmental Applicationsmentioning

confidence: 99%

“…Moving to the detection mechanisms themselves, the peroxidase-like activity of gold nanozymes is again the preferred approach for developing a sensor. Interestingly, many sensors for Hg detection have been reported in the literature using AuNP nanozyme activity [136,[176][177][178]180]. The reason behind it is that mercury can form an Au-Hg amalgam on the surface of the AuNP that enhances its peroxidase-like activity.…”

Section: Environmental Applicationsmentioning

confidence: 99%

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Gold Nanozymes: From Concept to Biomedical Applications

et al. 2020

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In recent years, gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase, oxidase, catalase, superoxide dismutase or reductase. This, merged with their ease of synthesis, tunability, biocompatibility and low cost, makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical analyses. Herein, over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential applications. The review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties, as well as external parameters such as pH or temperature. Yet, real applications often require specific biorecognition elements to be immobilized onto the nanozymes, leading to unexpected positive or negative effects on their activity. Thus, rational design of efficient nanozymes remains a challenge of paramount importance. Different implementation paths have already been explored, including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase activities. The review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities, as more than one of them could coexist. Likewise, further toxicity studies are required to ensure the applicability of gold nanozymes in vivo. Current challenges and future prospects of gold nanozymes are discussed in this review, whose significance can be anticipated in a diverse range of fields beyond biomedicine, such as food safety, environmental analyses or the chemical industry.

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Section: Environmental Applicationsmentioning

confidence: 99%

Section: Environmental Applicationsmentioning

confidence: 99%

Gold Nanozymes: From Concept to Biomedical Applications

et al. 2020

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“…Hg 2+ and Ag + are usually coexisting in water, soil and even biological systems [ 69 ]. Peng et al prepared core–shell Au@Pt nanoparticles for simultaneous colorimetric detection of Hg 2+ and Ag + [ 70 ]. Both Hg 2+ and Ag + were found to intensively inhibit the catalytic activity of Au@Pt NPs.…”

Section: Metal Ionsmentioning

confidence: 99%

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Alizadeh

Salimi

2021

J Nanobiotechnol

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With the rapid advancement and progress of nanotechnology, nanomaterials with enzyme-like catalytic activity have fascinated the remarkable attention of researchers, due to their low cost, high operational stability, adjustable catalytic activity, and ease of recycling and reuse. Nanozymes can catalyze the same reactions as performed by enzymes in nature. In contrast the intrinsic shortcomings of natural enzymes such as high manufacturing cost, low operational stability, production complexity, harsh catalytic conditions and difficulties of recycling, did not limit their wide applications. The broad interest in enzymatic nanomaterial relies on their outstanding properties such as stability, high activity, and rigidity to harsh environments, long-term storage and easy preparation, which make them a convenient substitute instead of the native enzyme. These abilities make the nanozymes suitable for multiple applications in sensing and imaging, tissue engineering, environmental protection, satisfactory tumor diagnostic and therapeutic, because of distinguished properties compared with other artificial enzymes such as high biocompatibility, low toxicity, size dependent catalytic activities, large surface area for further bioconjugation or modification and also smart response to external stimuli. This review summarizes and highlights latest progress in applications of metal and metal oxide nanomaterials with enzyme/multienzyme mimicking activities. We cover the applications of sensing, cancer therapy, water treatment and anti-bacterial efficacy. We also put forward the current challenges and prospects in this research area, hoping to extension of this emerging field. In addition to therapeutic potential of nanozymes for disease prevention, their practical effects in diagnostics, to monitor the presence of SARS-CoV-2 and related biomarkers for future pandemics will be predicted.

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“…Mercury and silver usually coexist in water, and peroxidase-like nanozymes have been developed that are sensitive to both metal ions. Surface modification of Au@Pt nanoparticles with sodium dodecyl sulfate effectively shielded most metal ions via complexation, except for Hg 2+ and Ag + [ 126 ]. The detection limits for Hg 2+ and Ag + were 3.5 and 2.0 nM, respectively.…”

Section: Detection Of Metal Ionsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Nanozymes for Environmental Pollutant Monitoring and Remediation

Wong¹,

Vuong²,

Chow³

2021

Sensors

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Nanozymes are advanced nanomaterials which mimic natural enzymes by exhibiting enzyme-like properties. As nanozymes offer better structural stability over their respective natural enzymes, they are ideal candidates for real-time and/or remote environmental pollutant monitoring and remediation. In this review, we classify nanozymes into four types depending on their enzyme-mimicking behaviour (active metal centre mimic, functional mimic, nanocomposite or 3D structural mimic) and offer mechanistic insights into the nature of their catalytic activity. Following this, we discuss the current environmental translation of nanozymes into a powerful sensing or remediation tool through inventive nano-architectural design of nanozymes and their transduction methodologies. Here, we focus on recent developments in nanozymes for the detection of heavy metal ions, pesticides and other organic pollutants, emphasising optical methods and a few electrochemical techniques. Strategies to remediate persistent organic pollutants such as pesticides, phenols, antibiotics and textile dyes are included. We conclude with a discussion on the practical deployment of these nanozymes in terms of their effectiveness, reusability, real-time in-field application, commercial production and regulatory considerations.

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Colorimetric assay for the simultaneous detection of Hg²⁺ and Ag⁺ based on inhibiting the peroxidase-like activity of core–shell Au@Pt nanoparticles

Abstract: A highly sensitive and selective colorimetric assay for Hg2+ and Ag+ was developed using core–shell Au@Pt nanoparticles.

Cited by 38 publications

References 47 publications

Gold Nanozymes: From Concept to Biomedical Applications

Gold Nanozymes: From Concept to Biomedical Applications

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Nanozymes for Environmental Pollutant Monitoring and Remediation

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Colorimetric assay for the simultaneous detection of Hg2+ and Ag+ based on inhibiting the peroxidase-like activity of core–shell Au@Pt nanoparticles

Abstract: A highly sensitive and selective colorimetric assay for Hg2+ and Ag+ was developed using core–shell Au@Pt nanoparticles.

Cited by 38 publications

References 47 publications

Gold Nanozymes: From Concept to Biomedical Applications

Gold Nanozymes: From Concept to Biomedical Applications

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

Nanozymes for Environmental Pollutant Monitoring and Remediation

Contact Info

Product

Resources

About

Colorimetric assay for the simultaneous detection of Hg²⁺ and Ag⁺ based on inhibiting the peroxidase-like activity of core–shell Au@Pt nanoparticles