Colorimetric and visual dopamine assay based on the use of gold nanorods

Teo, Peik See; Rameshkumar, Perumal; Pandikumar, Alagarsamy; Jiang, Zhong Tao; Altarawneh, Mohammednoor; Huang, Nay Ming

doi:10.1007/s00604-017-2435-5

Cited by 17 publications

(10 citation statements)

References 35 publications

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“…The intensity of the XRD peak corresponding to the (2 0 0) plane was slightly higher than that of the other XRD peaks. These results agree well with the findings of Teo et al [ 46 ]. The prepared AuNRs with absorption maxima of 700 nm by using the seed-mediated growth method.…”

Section: Experimental Analysissupporting

confidence: 94%

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency

et al. 2022

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The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity.

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Section: Experimental Analysissupporting

confidence: 94%

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency

et al. 2022

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“…S2) with an absorbance spectrum having an LSPR maximum centered at 550 ± 5 nm (n=96) (Fig. 1a), clearly indicating the presence of Au-nanostructures [20,30].…”

Section: Design and Characterization Of The Pda@ausd-based Filmmentioning

confidence: 96%

“…Noteworthy, no gold nanoparticles formation was noticed in the reaction solution, confirming that Au(III) reduction occurs only in the proximity of the PDA film surface. PDA film serves as anchoring surface for AuSDs formation/immobilization, which occurs because of the residual reducing capacity of the PDA free catechol moieties and the PDA ability to retain the neo-formed AuSDs [17,18,20]. A JMAK model (see section 2.4) has been used to describe the formation of the AuSDs onto PDA modified EPs.…”

Section: Design and Characterization Of The Pda@ausd-based Filmmentioning

confidence: 99%

“…The 'combination' of PDA and nanomaterials have been extensively exploited in the sensors and surfaces field [18,19]. The formation of metal nanoparticles (MNPs) mediated by PDA is reported for electrochemical (bio)sensors functionalization [15,18,20]. On the other hand, the PDA@MNP synergic features have been exploited for colorimetric assays, in solution, based on color shift related to the MNPs 'structural changes' [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…The formation of metal nanoparticles (MNPs) mediated by PDA is reported for electrochemical (bio)sensors functionalization [15,18,20]. On the other hand, the PDA@MNP synergic features have been exploited for colorimetric assays, in solution, based on color shift related to the MNPs 'structural changes' [20,21]. Several surfaces based on PDA@MNP have been proposed with different purposes (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Colorimetric determination of polyphenols via a gold nanoseeds–decorated polydopamine film

et al. 2020

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A polystyrene ELISA plate (EP) modified with a thin-film based on gold nano-seeds (AuSDs) assembled onto polydopamine (PDA) is proposed. The nano-decorated film (PDA@AuSD) allows to evaluate the polyphenols antioxidant capacity (AOC), through a colorimetric approach based on a seed-mediated growth strategy. Polyphenols, in the presence of the nano-decorated (PDA@AuSD) surfaces are able to drive an increase in size of the AuSDs according to their AOC; this produces an increase of the localized surface plasmon resonance (LSPR; maximum at λ ⁓ 550 nm) that is taken as analytical signal. The PDA@AuSD EPs manufacturing show good intra-plates repeatability (RSD ≤ 6.6%, n=96 wells) and inter-plates reproducibility (RSD ≤ 7.4%, n=748 wells), resulting stable for 1 year. The AuSDs growth kinetic has been studied using 11 polyphenols belonging to different chemical classes and 4 different food samples. The PDA@AuSD film results able to return selective quantitative (Abs550 vs. time) information on the food polyphenols AOC. Good repeatability (RSD ≤ 5.7%, n=12 EP wells) and reproducibility (RSD ≤ 8.1%, n=12 EP wells) was achieved, with acceptable determination coefficients (R 2 ≥ 0.990) and useful limits of detection ( ≤ 2.5•10 −5 mol L −1 ). The samples analyzed with the PDA@AuSD device have been successfully ordered according to their AOC in agreement with conventional optical methods. The PDA@AuSD plate allows multiple measurements (96 wells per EP) with a one-step strategy, overcoming the limitations related to the use of colloidal nanoparticles; in addition, since absorbance is measured after washing it not affetted by color or turbidity.

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