We report a facile one-pot hydrothermal synthesis of reduced graphene oxide-cobalt oxide nanocubes@platinum (rGO-Co 3 O 4 @Pt) nanocomposite and its application toward the electrochemical detection of nitric oxide (NO). The rGO-Co 3 O 4 @Pt nanocomposite was characterized by field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) mapping, X-ray diffraction (XRD) and Raman analyses. The nanocomposite modified glassy carbon (GC) electrode was used for the electrochemical oxidation of nitric oxide (NO) and it showed better catalytic performance in terms of catalytic peak current and shift in overpotential when compared to rGO, Co 3 O 4 nanocubes and rGO-Co 3 O 4 nanocomposite modified electrodes. The rGO-Co 3 O 4 @Pt nanocomposite modified electrode showed a better sensing ability toward the in-situ generated NO in NO 2 containing phosphate buffer solution (PBS) than the other controlled modified electrodes. The Pt nanoparticles present in the nanocomposite could enhance the sensing performance and the limit of detection (LOD) was found as 1.73 µM with signal-to-noise (S/N) ratio ~3 using amperometric i-t curve. Further, the nanocomposite modified electrode showed the selectivity toward the detection of NO in the presence of 100-fold higher concentration of other physiologically important analytes. The proposed sensor was stable, reproducible and selective toward the detection of NO.

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Cancer nanotechnology encourages cutting edge research utilizing nanomaterials for the diagnosis, therapy and prevention of cancer.