Color Visual Evoked Potentials in Children with Type 1 Diabetes: Relationship to Metabolic Control

Elia, Yesmino; Daneman, Denis; Rovet, Joanne; Abdolell, Mohamed; Lam, Wai Ching; Till, Christine; Erraguntla, Vasudha; Rubab, Shehla; Lodha, Nidhi; Westall, Carol A.

doi:10.1167/iovs.05-0178

Cited by 13 publications

(7 citation statements)

References 46 publications

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“…The time of luminance presentation consistently occurred between chromatic stimuli so as not to saturate the color vision system. Stimulus parameters were selected to optimize the chromatic response and differentiate between the chromatic and achromatic VEP response (see Elia et al 31 for the details). Chromatic and achromatic stimuli were produced using Vision Research Graphics (VRG) software (Durhan, NH).…”

Section: Methodsmentioning

confidence: 99%

Color vision in attention-deficit/hyperactivity disorder: A pilot visual evoked potential study

Kim

Banaschewski

Tannock

2015

Journal of Optometry

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Section: Methodsmentioning

confidence: 99%

Color vision in attention-deficit/hyperactivity disorder: A pilot visual evoked potential study

Kim

Banaschewski

Tannock

2015

Journal of Optometry

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“…The correlations between VEP latency and mean T1DM duration and HbA1c values were both significant (P < 0.001 and P < 0.001, respectively). Elia et al found no significant relationship between VEP latencies and mean HbA1c values in a study of 50 type 1 diabetic adults and 33 healthy control subjects (17). However, 50% of the patient group had low HbA1c levels (‹8 mg/dL), and this may explain the absence of a positive correlation in that study (17).…”

Section: Discussionmentioning

confidence: 78%

The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

et al. 2019

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Background: Asymtomatic santral nervous system disorder is frequently found in patients with diabetes. Neurophysiological tests were found to be objective and sensitive tool for detecting subclinical optic nerve and CNS disorders. Objectives: Our aim is to evaluate of the central nerve conduction changes using visual evoked potentials (VEP) and to demonstrate the effects of various risk factors on VEP parameters in children with type 1 diabetes mellitus (T1DM). Methods: Sixty children aged between 6 and 18 years and followed-up with a diagnosis of T1DM were enrolled in the study. Thirty healthy, age-matched children were enrolled as the control group. All patients and controls underwent the pattern reversal visual evoked potentials (PRVEP) test. Patients' HbA1c values, age, sex and duration of disease were evaluated from their hospital files. Results: Both right and left VEP latencies were significantly longer in the diabetic group than in the control group (P = 0.001 and P = 0.001, respectively). The mean duration of T1DM in the patient group was 5.5 years (min: 1 -max: 15). There was a positive correlation between longer VEP latency values and duration of DM, with coefficients of 0.49 for the right eye and 0.513 for the left eye (P < 0.001 and P < 0.001, respectively). Conclusions:We found that optic nerve conduction diminished significantly in children with T1DM. Visual evoked potential datas showed a significant prolongation of the latency of P-100. We recommend that all diabetic children be scanned with neurophysiological tests such as PRVEP for optic neuropathy.

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“…The idea of electrophysiological assessment of the parvocellular visual pathway by using chromatic visual evoked potentials (cVEPs) is not new [14][15][16][17][18][19][20][21][22][23] and may serve as an important additional test in electrophysiological evaluation of the visual system in daily clinical practice, especially in a pediatric population [24][25][26][27]. In our previous studies, cVEPs have been used to test children with congenital color deficiency [28], as well as school-age children (7-18 years) with normal color vision to obtain normative data [26].…”

Section: Introductionmentioning

confidence: 99%

Chromatic visual evoked potentials in young patients with demyelinating disease

2014

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The purpose of this study was to evaluate color vision in young patients with demyelinating disease both clinically and electrophysiologically. Thirty young patients (8-28 years, mean age 19 years) with demyelinating disease with or without a history of optic neuritis (ON) were investigated. Color vision was evaluated clinically with the Ishihara test and the Farnsworth-Munsell 100 hue (FM 100 hue) test and electrophysiologically with chromatic visual evoked potentials (cVEPs). Color deficiency axis and error score (ES) obtained with the FM 100 hue test were analyzed. cVEPs to isoluminant red-green (R-G) and blue-yellow (B-Y) stimuli were recorded. The stimulus was a 7 deg circle composed of horizontal sinusoidal gratings with a spatial frequency of 2 cycles/deg and 90% chromatic contrast. Onset-offset mode of stimulation (ON:OFF=300∶700 ms) was used. Since the majority of the patients were adults (>18 years), the negative wave (N wave) of the cVEP respones is the prominent part and therefore was analyzed. Sixty eyes were studied-22 with at least one episode of ON (ON group) and 38 without any clinically evident episode of ON (nON group). The average ES in the ON group was 179.18±171.8, whereas in the nON group it was 87.60±65.34. The average N-wave latency in the ON group was 144±44 ms for the R-G stimulus and 146±56 ms for the B-Y stimulus, whereas in the nON group, it was 117±13 ms for the R-G stimulus and 121±22 ms for the B-Y one. The average N-wave amplitude in the ON group was 9.3±7.1 μV for the R-G stimulus and 5.1±3.9 μV for the B-Y one, whereas in the nON group, it was 10.8±8.3 μV for the R-G stimulus and 6.4±4.3 μV for the B-Y one. A significant difference between the ON and the nON group was found: in the ON group, ES was higher (p=0.01) and N-wave latency was longer (p=0.01) compared with those in the nON group. The study showed that color vision is expectedly more affected in the ON group, but also often in the nON group, which may indicate increased parvocellular visual pathway vulnerability in demyelinating diseases.

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Color Visual Evoked Potentials in Children with Type 1 Diabetes: Relationship to Metabolic Control

Cited by 13 publications

References 46 publications

Color vision in attention-deficit/hyperactivity disorder: A pilot visual evoked potential study

Color vision in attention-deficit/hyperactivity disorder: A pilot visual evoked potential study

The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

Chromatic visual evoked potentials in young patients with demyelinating disease

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