Colon targeted bioadhesive pellets of curcumin and cyclosporine for improved management of inflammatory bowel disease

Desai, Neha; Momin, Munira

doi:10.1007/s13346-020-00756-x

Cited by 16 publications

(11 citation statements)

References 45 publications

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“…Results showed that curcumin and cyclosporine pellet cores could improve the acetic acid-induced UC rat model. It was confirmed by analyzing the body weight, clinical parameters, macroscopic and microscopic parameters [118]. Oshi et al formulated a colon-targeted core−shell using curcumin nanocrystals as cores and pH-responsive polyelectrolyte multilayers of chitosan/sodium alginate/cellulose acetate phthalate as shells (CAP1AG4CH5@CUNCs) to deliver a drug precisely into the inflamed colon in UC.…”

Section: Curcumin Combinations With Other Therapeutic Molecules and Modified Curcumin Formulations In Inflammatory Bowel Diseasementioning

confidence: 92%

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Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

et al. 2021

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Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder of the small intestine and colon. IBD includes ulcerative colitis (UC) and Crohn’s disease (CD), and it is a major factor for the development of colon cancer, referred to as colitis-associated cancer (CAC). The current treatment of IBD mainly includes the use of synthetic drugs and monoclonal antibodies. However, these drugs have side effects over long-term use, and the high relapse rate restricts their application. In the recent past, many studies had witnessed a surge in applying plant-derived products to manage various diseases, including IBD. Curcumin is a bioactive component derived from a rhizome of turmeric (Curcuma longa). Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-κB, JAKs/STATs, MAPKs, TNF-γ, IL-6, PPARγ, and TRPV1) and effectively reduce the progression of IBD with promising results. Thus, curcumin is a potential therapeutic agent for patients with IBD once it significantly decreases clinical relapse in patients with quiescent IBD. This review aims to summarize recent advances and provide a comprehensive picture of curcumin’s effectiveness in IBD and offer our view on future research on curcumin in IBD treatment.

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Section: Curcumin Combinations With Other Therapeutic Molecules and Modified Curcumin Formulations In Inflammatory Bowel Diseasementioning

confidence: 92%

“…Desai and Monim, 2020 [118] Colon targeted bioadhesive pellets of curcumin and cyclosporine for improved management of inflammatory bowel disease…”

mentioning

confidence: 99%

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

et al. 2021

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“…Novel site-specific colon targeted approaches Reference Systemic absorption takes place because of delivery to nonspecific cells Systemic absorption is very low due to its site-specific nature [1] Side effects are possible due to systemic absorption of drugs Very minimal side effects due to its site-specific nature [1,4] High doses of the drug have to be administered for obtaining the desired therapeutic effect Reduction of doses is possible. The desired therapeutic effect can be obtained with very low doses [1] Decreased patient compliance due to high frequency and dose of drugs administered Increased patient compliance due to less frequency and dose of drugs administered [4,[7][8][9][10]…”

Section: Conventional Drug Delivery Systemsmentioning

confidence: 99%

“…The medical or surgical remedy is not available for IBD. Oral colon targeted drug delivery is used for the therapy of IBD, which is largely effective only in mitigating symptoms [3,4]. Both ulcerative colitis and Crohn's disease treatment are similar, although significant differences exist including limited or lack of response and increased need for surgery in Crohn's disease [5].…”

Section: Introductionmentioning

confidence: 99%

“…Further to the above approaches, there are novel approaches such as (i) pressure controlled delivery, (ii) CODESTM (combined approach of pH-dependent and microbially triggered delivery), (iii) osmotic drug delivery, and (iv) multiparticulate systems like microspheres and nanoparticles [6]. These approaches are developed for the therapy of IBD for increasing drug localization and accessibility of drug at the target site, reduction of dose, and side-effects associated with the conventional drug delivery systems [4,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Recent Approaches Involved in Colonic Drug Targeting for the Treatment of Inflammatory Bowel Disease: A Review

Swaminathan

Rajesh

2021

Int J App Pharm

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The objective of the review is to present the contemporary approaches involved in colonic drug targeting for the therapy of inflammatory bowel disease (IBD). The adverse reactions and side-effects of the conventional drug delivery systems are largely on account of the systemic absorption of the drugs from the small intestine. Moreover, in current drug delivery systems, the drug has to be frequently administered and also in larger doses which greatly reduces patient compliance. Various approaches which are being described here mainly target the colonic region specifically for improved therapy of IBD, by increasing localization and accessibility of the drug to the target site. Also, these approaches will result in the reduction of dose and minimization of adverse effects combined with the use of conventional drug delivery systems.

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Mucoadhesive Pellets for Drug Delivery Applications: A Critical Review

Singh¹,

Devi²,

Barik³

et al. 2021

Progress in Adhesion and Adhesives

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Colon targeted bioadhesive pellets of curcumin and cyclosporine for improved management of inflammatory bowel disease

Cited by 16 publications

References 45 publications

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

Recent Approaches Involved in Colonic Drug Targeting for the Treatment of Inflammatory Bowel Disease: A Review

Mucoadhesive Pellets for Drug Delivery Applications: A Critical Review

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