Colon Cancer Arising in an Ulcer Scar due to Intestinal Behcet's Disease

Abstract

Neoplasms rarely arise in the intestinal lesion of Behçet's disease. We present a 77-year-old man with Behçet's disease who developed colon cancer in the ileocecal region. Ileocecal resection was performed and pathological examination of the specimen revealed advanced colon carcinoma (pT3, N1, M0). The lesion was associated with destroyed tunica muscularis and severe fibrosis suggesting a transmural ulcer scar (Ul-IVs). The p53 gene mutation analysis of the tumor showed a heterozygous deletion. This case indicates there is a possibility that cancer may develop in intestinal lesions of patients with Behçet's disease as well as in those with other inflammatory bowel diseases.

Behcet's disease associated with malignancy: a report of 41 Chinese cases

“…Based on the reports and literature review by Kaklamani, 3 we performed a Medline search from 2004 through 2012 which yielded a total of 167 BD cases with malignancies. 3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Malignancies were diagnosed after BD in 132 cases, coincidentally with BD in eight cases and before BD in 27 cases (Table 4). However, several studies demonstrated that the age-standardized rate of cancer in the population of BD patients did not differ significantly from that of the corresponding general population.…”

“…Summaryof BD patients with various types of malignancies from PUMCH and in the literature3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] …”

Behçet’s disease and comorbidity: internal case reports and literature review

“…At present, BD, in contrast to nonspecific ulceratic colitis and Crohn's disease, does not act as a risk factor leading to the development of colon cancer [7,8]. Individual cases of large intestine neoplasm concurrent with BD are described in the literature [3,4,9,10]. A group of authors from Tunisia gives a detailed case study of colon cancer developed by a BD patient [11].…”

Morbidity of Solid Cancer in Behçet's Disease: Analysis of 11 Cases in a Series of 506 Patients

“…Colon carcinoma confined to the ileocecal region with histopathological evidence of transmural ulcer scarring has been reported; in addition, the ileocecal region is the most commonly involved region in cases of BD with gastrointestinal involvement 31. Recently, the biology of chronic inflammation was determined to play a major role in cancer development.…”