Behcet's disease associated with malignancy: a report of 41 Chinese cases

Abstract

This study demonstrated that MDS and colorectal cancer were the most common hematologic malignancy and malignant solid neoplasm associated with BD, respectively. Gastrointestinal involvement is likely to be a risk factor for BD patients to develop malignancy. Further studies will be required to ascertain the pathogenic link between these two entities.

Behcet's disease

“…Shadmanfar reports that, contrary to previous reports, there was no relationship between plasma homocysteine levels and HLA B‐51 in BD patients, nor in their control group . Lin reports 6.3% of malignancy in hospitalized BD patients, which is much higher than previous reports (6.3% vs . 0.24%)…”

Anticoagulation of Behcet’s Disease with Thrombosis: A Series of 28 Cases in a Tertiary Care Centre in Saudi Arabia

“…Female gender, older age and gastrointestinal tract involvement were more among patients with malignancy. Longer disease duration was more seen in BD patients with solid neoplasms [23].…”

Hepatocellular carcinoma associated to Behçet's disease

“…The exact mechanism promoting carcinogenesis associated with BD is still unclear. It appears to be multifactorial involving persistent chronic inflammation, immune dysfunction, vasculitis, and some immunosuppressive therapies used in this disease [6,[8][9][10]20] .…”

“…Behçet's disease (BD) is a non-specific systemic vasculitis that is particularly common in young people around the Mediterranean and the old Silk Road [6] . Recently a particularly increased risk of cancer during this disease was reported by several studies [6][7][8] : standardized incidence ratio (SIR) at 2.13-3.10 [9] and Hazard Ratio (HR) at 1.134 [10] .…”