Behcet's disease

Davatchi, Fereydoun

doi:10.1111/1756-185x.12378

Cited by 34 publications

(25 citation statements)

References 14 publications

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“…Genital ulcers were widely distributed with a high severity score in patients between age ranges (18–30) and (31–43), within these age ranges males were higher in their GUSS than females (Fig. 3a ), this was consistent with the BD literature [ 36 , 37 ]. GUSS mean declined in the higher age range (44–60) in both genders with no significant difference between males and females.…”

Section: Resultssupporting

confidence: 88%

Genital ulcer severity score and genital health quality of life in Behçet’s disease

Senusi

Seoudi

Bergmeier

et al. 2015

Orphanet J Rare Dis

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BackgroundBehçet’s Disease (BD) is a chronic auto-inflammatory, multisystem relapsing/remitting disorder of unknown aetiology. Oro-genital ulceration is a key feature of the disease and has a major impact on the patients’ quality of life. Other clinical manifestations include ocular inflammation, rheumatologic and skin involvement, while CNS and vascular complications can lead to considerable morbidity. The availability of a valid monitoring tool for BD activity is crucial in evaluating the impact of the disease on daily life activity. The aims of this study were to validate a novel tool for monitoring genital ulceration severity in BD and to assess the impact of genital ulcers on the Genital Health Quality of Life (GHQoL).MethodsGenital Ulcer Severity Score (GUSS) was developed using six genital ulcer characteristics: number, size, duration, ulcer-free period, pain and site. A total of 207 BD patients were examined, (137 females: mean age ± SD: 39.83 ± 13.42 and 70 males: mean age ± SD: 39.98 ± 11.95) from the multidisciplinary Behçet’s Centre of Excellence at Barts Health NHS Trust. GUSS was used in conjunction with Behçet’s Disease Current Activity Form (BDCAF).ResultsThe over-all score of GUSS showed a strong correlation with all genital ulcer characteristics, and the strongest correlation was with the pain domain (r = 0.936; P < 0.0001). Ulcer average size and ulcer pain were the major predicting factors in GUSS (β = 0.284; β = 0.275) respectively, and P-values were significant. Multivariate regression analysis indicated that the ulcer pain, size and site are the main ulcer characteristics having an influence on the GHQoL (R2: 0.600; P < 0.0001).ConclusionsThis study established the practicality of GUSS as a severity monitoring tool for BD genital ulcers and validated its use in 207 patients. Genital ulcers of BD have a considerable impact on the patients GHQoL.Electronic supplementary materialThe online version of this article (doi:10.1186/s13023-015-0341-7) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 88%

Genital ulcer severity score and genital health quality of life in Behçet’s disease

Senusi

Seoudi

Bergmeier

et al. 2015

Orphanet J Rare Dis

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“…Resistance to treatment still occurs, although it is much better than 29 years ago . The first‐line treatment is cytotoxic drugs and prednisolone, and in resistant cases biological agents may be of help …”

Section: Resultsmentioning

confidence: 99%

“…In the presence of cerebral sinus thrombosis and related neurological manifestations, it is easier to relate this to BD . Neurological manifestations have to be treated aggressively with cytotoxic drugs and prednisolone, and if resistant, the use of biological agents …”

Section: Resultsmentioning

confidence: 99%

Adult Behcet's disease in Iran: analysis of 6075 patients

et al. 2015

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“…3,4 Although the etiopathogenesis of BD has not been completely identified, it is considered to be manifested due to intense inflammatory response triggered by an infectious agent in individuals having genetic predisposition. [5][6][7][8] Better understanding of the etiology and pathogenesis of BD at the cellular and biochemical levels is required in order to develop cure and prevention against the disease. Recently conducted studies have focused on oxidative stress in diabetic retinopathy.…”

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confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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Behcet's disease

Cited by 34 publications

References 14 publications

Genital ulcer severity score and genital health quality of life in Behçet’s disease

Genital ulcer severity score and genital health quality of life in Behçet’s disease

Adult Behcet's disease in Iran: analysis of 6075 patients

Endocan Measurement for Active Behçet Disease

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