Genital ulcer severity score and genital health quality of life in Behçet’s disease

Senusi, Amal; Seoudi, Noha; Bergmeier, Lesley A.; Fortune, Farida

doi:10.1186/s13023-015-0341-7

Cited by 35 publications

(27 citation statements)

References 36 publications

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“…The OUSS tool validated for BD and was provided to assess oral ulcer severity [ 39 , 40 ]. The six OUSS characteristics: number, size, duration of ulcers, ulcer-free period, pain, and site of ulcers were recorded.…”

Section: Methodsmentioning

confidence: 99%

The influence of oral health and psycho-social well-being on clinical outcomes in Behçet’s disease

2018

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This study was designed to investigate the association of oral ulceration and oral health factors, together with psycho-social well-being in Behçet’s disease (BD), and to clarify the importance of psycho-social support of patients in the overall management of BD. The study comprised of a cohort of 146 BD patients (mean age ± SD = 39.65 ± 13.20) and 20 recurrent aphthous stomatitis (RAS) patients (mean age ± SD = 42.32 ± 11.32). Oral ulcer severity score (OUSS), Behçet’s disease current activities form (BDCAF), hospital anxiety and depression scale (HADS), and the work and social adjustment scale (WSAS) were investigated. Oral health risk factors were also included. The analysis of variance, regression, and factor analysis were used to scrutinise the data. Almost 73% of patients were at high caries risk in BD and RAS groups. Thirty-nine percent of BD and forty percent of RAS had a score of BPE3 (probing depth 3.5–5.5 mm). Regression analysis revealed that OUSS and WSAS had a positive impact to increase the BDCAF score in BD patients (β = 0.395, P = 0.001; β = 0.240, P = 0.019), respectively. Dental health, periodontal health, anxiety, depression, and WSAS variables had strong loadings by factor analysis based on gender and at the time of present and absent of oral ulceration. The main oral ulcer characteristics that had significant influences on the total of oral health quality of life by 68.6% were: size, duration, ulcer-free period, and pain. The results highlighted the significant influence of oral ulceration, patients’ oral health, diet, and psycho-social well-being as multi-factorial causes on increasing disease activity in BD patients.Electronic supplementary materialThe online version of this article (10.1007/s00296-018-4117-y) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

The influence of oral health and psycho-social well-being on clinical outcomes in Behçet’s disease

2018

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“…In addition, many patients with skin involvement had problems with sexual activity. This may be related to findings in one study that showed that 90% of patients with BD who experienced skin involvement experienced genital ulcers [15,21].…”

Section: Discussionmentioning

confidence: 61%

“…Blackford et al [14] found that oral and genital ulcers may cause deterioration in personal relationships and daily activity and impact the QOL of patients with BD. Senusi et al [15] indicated that genital ulcer pain was the major reason for difficulties in sexual activity, walking, and sitting.…”

Section: Discussionmentioning

confidence: 99%

Identification of physical and psychosocial problems based on symptoms in patients with Behçet’s disease

et al. 2019

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The purpose of this study was to use the International Classification of Functioning, Disability and Health (ICF) to identify physical and psychosocial problems associated with symptoms of Behçet's disease (BD) in Japanese patients. Thirty patients with BD were interviewed in a pilot study using the "ICF Checklist", and a team of medical experts selected categories related to physical and psychosocial aspects of BD. To identify specific physical and psychosocial problems of Japanese patients with BD, 100 new patients were interviewed using the selected categories. Among the 128 categories in the original ICF Checklist, 80 categories were identified as impaired, and another 12 ICF categories were added based on expert discussion of patients input. The number of problem categories was significantly greater in patients with BD with eye involvement and fatigue (eye involvement, 25.7 categories; fatigue, 25.2 categories; both P < 0.001). Specifically, patients with eye involvement had more difficulties with problems in daily life, such as writing (odds ratio 4.2), understanding such nonverbal messages as gestures and facial expressions (13.7), moving (5.7), walking in intense sunlight and bright light (17.6), and patients with fatigue had more difficulties with climate problems such as symptoms getting worse at the turn of the seasons or on cold days (2.5), compared to those without these symptoms. This study demonstrated that support focusing not only on physical symptoms but on other aspects of life as well is necessary for patients with BD, particularly patients with eye involvement and fatigue.

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“…In our patient, the painless vaginal ulcer was incidentally noticed during a regular prenatal examination. Senusi et al examined 137 cases of Behçet disease with primary genital lesions and reported that only 9% patients had ulcers in the vagina; the remaining ulcers were located in the labia or vulva [4]. When a vaginal ulcer is detected, it is necessary to rule out infectious diseases, malignant tumors, and Crohn's disease [5–7].…”

Section: Discussionmentioning

confidence: 99%

Genital Ulcer of Behçet Disease Localized in the Vagina May Lack Pain, Making It Difficult to Assess

Obata

Kobayashi

Toda

et al. 2019

Case Reports in Rheumatology

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Genital ulcer is one of the main clinical symptoms of Behçet disease; ulcers mostly occur in the vulva and are usually quite painful. We present an unusual case of Behçet disease wherein a painless genital ulcer was localized in the vagina. Our case is of a 43-year-old woman diagnosed with Behçet disease that was controlled with prednisolone. She became pregnant and developed fever, oral ulcers, and arthralgia at 16 weeks of gestation. Although a relapse of Behçet disease was suspected, ulceration and pain of the vulva were not observed. At 18 and 28 weeks of gestation, a vaginal ulcer was observed during regular prenatal examination, but the patient had no pain or other symptoms in the vulva. The vaginal ulcer healed at 29 weeks of gestation. No recurrence of the vaginal ulcer and other symptoms of Behçet disease were seen on subsequent follow-up examination at 1 month after delivery. Although genital ulcers of Behçet disease are common in the vulva and are generally painful, if they are located in the vagina, they can be painless. If Behçet disease is suspected based on other symptoms, a vaginal examination should be conducted as necessary for accurate evaluation of Behçet disease.

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Genital ulcer severity score and genital health quality of life in Behçet’s disease

Cited by 35 publications

References 36 publications

The influence of oral health and psycho-social well-being on clinical outcomes in Behçet’s disease

The influence of oral health and psycho-social well-being on clinical outcomes in Behçet’s disease

Identification of physical and psychosocial problems based on symptoms in patients with Behçet’s disease

Genital Ulcer of Behçet Disease Localized in the Vagina May Lack Pain, Making It Difficult to Assess

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