Morbidity of Solid Cancer in Behçet's Disease: Analysis of 11 Cases in a Series of 506 Patients

Na, So Young; Shin, Jaeyoung; Lee, Eun‐So

doi:10.3349/ymj.2013.54.4.895

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…Ureteroscopic control reevaluation after 6 months of treatment urethritis or cystitis. Cyclophosphamide treatment was the cause for most bladder located cancers in this patient category, but the rate was not higher than in other patients (6). Rare urethrovaginal fistulas were identified.…”

Section: Discussionmentioning

confidence: 52%

Rare case of female Behçet’s disease with urological involvement

Cobilinschi¹,

Belinski²,

Opriş-Belinski³

2019

Ro J Rheumatol.

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Behçet's disease is a systemic vasculitis with several well-defined organ manifestations, including various mucocutaneous features. Among them, the urinary tract involvement is rarely cited, most data focusing on bladder dysfunction due to neuroBehçet. This article presents a rare case of a young female patient with urological complaints that was diagnosed with right ureteral ulceration, later confirmed as vasculitis at the histopathological examination. Urological intervention together with adequate immunosuppression let to the healing of the ulcerative lesion. The unusual vasculitic lesion site indicates the complexity of Behçet's disease that requires careful investigation and treatment.

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Section: Discussionmentioning

confidence: 52%

Rare case of female Behçet’s disease with urological involvement

Cobilinschi¹,

Belinski²,

Opriş-Belinski³

2019

Ro J Rheumatol.

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“… 6 , 7 In a few case series and case reports, BD has been sporadically associated with malignancy; however, the results of these investigations remain controversial. 8 – 10 In particular, a number of studies have reported that BD is associated with hematologic diseases such as myelodysplastic syndrome (MDS) and aplastic anemia (AA), as well as with hematologic cancers. 8 , 9 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

“…Several studies have evaluated the relationship between BD and cancer. 8 – 10 However, most of them were hospital-based chart reviews or case reports with inconsistent results, and none of them focused on intestinal BD. A number of Western population-based studies have provided useful information regarding cancer risk in CD and UC.…”

Section: Introductionmentioning

confidence: 99%

Cancer Risk in Patients with Intestinal Behçet’s Disease: A Nationwide Population-Based Study

et al. 2018

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Background/AimsThe relationship between intestinal Behçet’s disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with intestinal BD.MethodsUsing the National Health Insurance claims records, we collected data on 365 patients who had been diagnosed with intestinal BD between 2011 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with intestinal BD in comparison with the general population were calculated.ResultsAmong 167 men with intestinal BD, four cases of cancer were observed; among 191 women with BD, eight cases of cancer were observed. The risk of all cancers was significantly higher in women with intestinal BD than in women of the general population (SIR, 4.27; 95% confidence interval [CI], 1.84 to 8.41). However, in men with intestinal BD, the risk of all cancers was not significantly higher than that in men of the general population (SIR, 2.08; 95% CI, 0.57 to 5.33). The risk of hematologic cancer was significantly higher in both men and women with intestinal BD than in their counterparts in the general population (SIR, 23.90; 95% CI, 2.89 to 86.32 in men; SIR, 34.47; 95% CI, 4.17 to 124.51 in women). In particular, patients with intestinal BD showed a higher risk of leukemia and myelodysplastic syndrome than the general population.ConclusionsPatients with intestinal BD demonstrated a higher risk of hematologic cancer, especially leukemia, than the general population. Furthermore, women with intestinal BD showed a higher risk of all cancers.

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“…However, data on the relationship between BD and solid cancers are very scarce. Moreover, most previous studies investigating the associations between BD and cancer were case reports or hospital-based chart reviews with inconsistent results [ 10 , 11 , 14 ]. Thus, based on current evidence, it is difficult to conclude that BD itself increases the risk of cancer development.…”

Section: Introductionmentioning

confidence: 99%

Cancer risk in Korean patients with Behçet’s disease: A nationwide population-based study

et al. 2017

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BackgroundVarious immune-mediated diseases are associated with increased malignancy risks. However, the relationship between Behçet’s disease (BD) and cancer remains unclear. We conducted a nationwide, population-based study to determine the risk of cancer in patients with BD.MethodsUsing National Health Insurance claims records, we collected data from 2402 patients diagnosed with BD between 2013 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with BD in comparison with the general population were calculated.ResultsThe risks of overall cancer (SIR, 3.54; 95% confidence interval, 2.35–5.11 in men and 2.17; 1.58–2.92 in women) and solid cancer (3.10; 1.94–4.69 in men and 2.13; 1.52–2.90 in women) were greater in patients with BD than in the general population. There were significantly increased risks for these solid cancers: colorectal (4.26; 1.38–9.94), liver (4.00; 1.09–10.25), bone/articular cartilage (55.66; 1.41–310.14), prostate (7.05; 1.45–20.60), and brain/central nervous system (28.32; 3.43–102.31) in men; and the lips/oral cavity/pharynx (13.97, 1.69–50.47), liver (12.78; 5.14–26.33), lungs (4.35; 1.18–11.13), other female genital organs (53.57; 1.36–298.49), and eyes (128.26; 3.24–714.59) in women. Patients with BD had a greater risk of myelodysplastic syndrome (MDS) than the general population did (65.72; 7.96–237.41 in men and 53.86; 11.11–157.40 in women), but not of hematological cancer.ConclusionsCompared to the general population, Korean patients with BD had greater risks of overall cancer, some solid cancers, and MDS, but not of hematological cancer.

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Morbidity of Solid Cancer in Behçet's Disease: Analysis of 11 Cases in a Series of 506 Patients

Cited by 12 publications

References 32 publications

Rare case of female Behçet’s disease with urological involvement

Rare case of female Behçet’s disease with urological involvement

Cancer Risk in Patients with Intestinal Behçet’s Disease: A Nationwide Population-Based Study

Cancer risk in Korean patients with Behçet’s disease: A nationwide population-based study

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