Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Donadu, Matthew Gavino; Peralta-Ruiz, Yeimmy; Usai, Donatella; Maggio, Francesca; Molina-Hernández, Junior Bernardo; Rizzo, Davide; Bussu, Francesco; Rubino, Salvatore; Zanetti, Stefania Anna Lucia; Paparella, Antonello; Chaves‐López, Clemencia

doi:10.3390/jof7050383

Cited by 50 publications

(47 citation statements)

References 53 publications

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“… 37 In addition, amphotericin B combined with Ruta graveolens essential oil has also shown synergistic effects against C. albicans and C. tropicalis in vitro. 36 These results suggest that these natural compounds might provide a new promising strategy against Candida infection in the future.…”

Section: Discussionmentioning

confidence: 91%

“… 35–38 Some essential oils extracted from plants have displayed inhibitory effects on the growth and activity of common Candida isolates. 35 , 36 , 38 UOST5-NPS, a novel anticandidal azole agent based on essential oils, has been developed for the newly emerged Candida auris. 37 In addition, amphotericin B combined with Ruta graveolens essential oil has also shown synergistic effects against C. albicans and C. tropicalis in vitro.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non-albicans Candidemia: A Retrospective Observational Study

Liu¹,

Zhong²,

Zhou³

et al. 2021

IDR

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Purpose Candida albicans ( C. albicans ) candidemia has been well reported in previous studies, while research on non -albicans Candida (NAC) bloodstream infections remains poorly explored. Therefore, the present study aimed to investigate the clinical characteristics and outcomes of patients with NAC candidemia. Patients and Methods We recruited inpatients with candidemia from January 2013 to June 2020 in a tertiary hospital for this retrospective observational study. Results A total of 301 patients with candidemia were recruited in the current study, including 161 (53.5%) patients with NAC candidemia. The main pathogens in NAC candidemia were Candida tropicalis ( C. tropicalis ) (23.9%), Candida parapsilosis (15.6%) and Candida glabrata (10.3%). Patients with NAC candidemia had more medical admissions ( P =0.034), a higher percentage of hematological malignancies ( P =0.007), a higher frequency of antifungal exposure ( P =0.012), and more indwelling peripherally inserted central catheters ( P =0.002) than those with C. albicans candidemia. In a multivariable analysis, prior antifungal exposure was independently related to NAC candidemia (adjusted odds ratio [aOR], 0.312; 95% confidence interval [CI], 0.113–0.859). Additionally, NAC was obviously resistant to azoles, especially C. tropicalis had a high cross-resistance to azoles. However, no significant differences were noted in the mortality rates at 14 days, 28 days and 60 days between these two groups. Conclusion NAC is dominant in candidemia, and prior antifungal exposure is an independent risk factor. Of note, although the outcomes of NAC and C. albicans candidemia are similar, drug resistance to specific azoles as well as cross-resistance frequently occurs in patients with NAC candidemia, and this drug resistance deserves attention in clinical practice and further in-depth investigation.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non-albicans Candidemia: A Retrospective Observational Study

Liu¹,

Zhong²,

Zhou³

et al. 2021

IDR

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“…Essential oils are well-known for their bioactivities, e.g., antimicrobial and antioxidant, and have long been used in different traditional medicine systems as well as in modern medicine, cosmetics, and pharmaceutical products [ 29 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. Their applications as an insecticidal, larvicidal, nematocidal, pesticidal, phytotoxic, and insect-repellent agents are also well-documented [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ].…”

Section: Bioactivitiesmentioning

confidence: 99%

“…The essential oil of the aerial parts of R. graveolens exhibited antifungal activity against Melassezia furfur , which is usually found on the human skin and is responsible for skin diseases and dermatological conditions [ 88 ]. This essential oil was also active against several Candida species, namely, C. albicans (MIC 8.2 μg/mL), C. parapsilopsis (MIC 16.4 μg/mL), C. glabrata (MIC 4.1 μg/mL), and C. tropicalis (MIC 131.0 μg/mL) [ 89 ], and the plant pathogenic fungi Sclerotinia sclerotiorum (which causes white mold disease in plants) [ 90 ], Bipolaris oryzae , and Gerlachia oryzae [ 91 , 92 ].…”

Section: Bioactivitiesmentioning

confidence: 99%

Ruta Essential Oils: Composition and Bioactivities

et al. 2021

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Ruta L. is a typical genus of the citrus family, Rutaceae Juss. and comprises ca. 40 different species, mainly distributed in the Mediterranean region. Ruta species have long been used in traditional medicines as an abortifacient and emmenagogue and for the treatment of lung diseases and microbial infections. The genus Ruta is rich in essential oils, which predominantly contain aliphatic ketones, e.g., 2-undecanone and 2-nonanone, but lack any significant amounts of terpenes. Three Ruta species, Ruta chalepensis L., Ruta graveolens L., and Ruta montana L., have been extensively studied for the composition of their essential oils and several bioactivities, revealing their potential medicinal and agrochemical applications. This review provides a systematic evaluation and critical appraisal of publications available in the literature on the composition and bioactivities of the essential oils obtained from Ruta species and includes a brief outlook of the potential applications of nanotechnology and chitosan-based products of Ruta essential oils.

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“…Studies have shown that essential oils have the effect of resisting multi-drug resistant bacteria, including Candida tropicalis, Candida parapsilosis, Candida and trichomonas. [6][7][8] Geraniol is one of the representatives of acyclic isoprenoid monoterpenes, which can be separated from the essential oils of aromatic plants, including Cinnamomum tenuipilum, Valeriana officinalis and several other plants. 9 It was widely used in the food industry and medicine.…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Efficiencies of Geraniol as an Anti-Inflammatory, Antioxidant, and Antibacterial, Natural Agent Against Methicillin-Resistant Staphylococcus aureus Infection in vivo

Lin¹,

Long²,

Qiu³

et al. 2021

IDR

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Introduction: Antibiotics wee widely used as feed additives in animal husbandry. With the increase of drug resistance of bacteria, there is an urgent need to find alternatives to antibiotics. Clinically, methicillin-resistant Staphylococcus aureus (MRSA) infections account for about 25% to 50% of Staphylococcus aureus infections worldwide. Similarly, it is also one of the pathogens that cause serious animal infections. Methods: We established a mouse model of systemic infection of MRSA to study the preventive effect of geraniol on MRSA and the immunomodulatory effect of geraniol. The mice in the experiment were injected with geraniol by intramuscular injection and were fed intraperitoneally with minimum lethal dose of MRSA. Then, the survival rate, inflammatory cytokines, oxidative stress factors in serum were measured. These values were used to estimate the bacterial load in different organs and to assess histopathological changes in the lungs, liver and kidneys. Results: The above-mentioned two ways of using geraniol could prevent MRSA infection in vivo in mice and showed a significant dose-response relationship. In other words, geraniol significantly decreased the concentrations of inflammatory cytokines and oxidative stress factors in MRSA-infected mice. At the same time, the level of glutathione peroxidase also increased in a dose-proportional relationship. In the group of mice treated with geraniol, their superoxide dismutase levels were significantly higher than those in the vancomycin. After treatment with geraniol, the burden of MRSA decreased. No obvious histopathological abnormalities were found in the liver and kidney of MRSA-infected mice. In addition, geraniol improved the inflammatory changes in the lungs. Conclusion:The results indicated that geraniol was a natural substance that could be used as an anti-inflammatory, antioxidant and antibacterial substance to protect mice from MRSA systemic infection. Generally, the research shows that as a natural medicine, geraniol has broad potential in the development and application of antibiotic substitutes.

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Colombian Essential Oil of Ruta graveolens against Nosocomial Antifungal Resistant Candida Strains

Cited by 50 publications

References 53 publications

Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non-albicans Candidemia: A Retrospective Observational Study

Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non-albicans Candidemia: A Retrospective Observational Study

Ruta Essential Oils: Composition and Bioactivities

The Inhibitory Efficiencies of Geraniol as an Anti-Inflammatory, Antioxidant, and Antibacterial, Natural Agent Against Methicillin-Resistant Staphylococcus aureus Infection in vivo

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