Collagenase Ointment and Polymyxin B Sulfate/Bacitracin Spray Versus Silver Sulfadiazine Cream in Partial-Thickness Burns: A Pilot Study

Soroff, Harry S.; Sasvary, Dawn

doi:10.1097/00004630-199401000-00003

Cited by 57 publications

(33 citation statements)

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“…We found a significant reduction in paraffin gauze use and an increase in nanocrystalline silver and silver carboxymethylcellulose applications between 2005 and 2006. In this type of burn, our healing time (22 days) was similar to those published in literature (15-22 days), [17][18][19] and subgroup analysis showed a surprising difference of 11 days between 2005 and 2006.…”

Section: Table 5 Healing Times For the Different Dressings Used Accorsupporting

confidence: 87%

“…17 When collagenase was added with polymyxin B sulphate/bacitracin spray, the healing time was reduced to 10 days (compared to 15 days for silver sulphadiazine alone). 18 Finally, biosynthetic dressings favoured wound regeneration processes when compared in controlled, randomised trials to silver-containing products: they significantly decreased pain and total healing time (10 days vs 15 days) without increasing the cost of out-patient burn care. 19 When added with low-concentration silver, they favoured re-epithelisation and prevented infections.…”

Section: Table 5 Healing Times For the Different Dressings Used Accormentioning

confidence: 99%

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A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Gravante

Montone

2010

annals

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Ann R Coll Surg Engl 2010; 92: 118-123 118Dressings have always been an important issue in reconstructive surgery to obtain better aesthetic and functional outcomes. This is particularly true in burns, where infections and contractures are more frequent than in other fields. Over latter years, pharmacological research has produced several products with different purposes: avoidance of infection (i.e. silvercontaining products), promotion of re-epithelialisation (alginates, hyaluronic acid-derived products), or both.In the ambulatory facility of our burn centre, we use different products for different purposes. Although we try to use them according to burn thickness and local status, no clear guideline exists and much of the decision is often left to the surgeon's personal experience. During the last days of 2005, new silver-based products (nanocrystalline silverActicoat, Smith and Nephew, and silver carboxymethylcellulose -Aquacel Ag, Convatec) were introduced in our clinical practice. In the present study, we analysed burn outcomes, in terms of healing times, during the last 2 months of 2005 and the first 2 months of 2006, to see if changes in wound care corresponded to an amelioration of healing times. We also tried to correlate eventual differences with those obtained from other products already in use. Patients and MethodsAfter local Institutional Review Board approval was obtained, we gathered data from patients treated in the ambulatory facility of our burn centre during the last 2 months of 2005 and the first 2 months of 2006. We excluded from the study: (i) admitted patients; (ii) patients with mixed superficial partial thickness and deep partial thickness burns; (iii) patients with full-thickness burns; and (iv) operated (2006, 19; 2005, 29 days; Student's t-test, P < 0.01). Among all dressings, paraffin gauzes had the shortest healing times in superficial burns (5 days); with silver-based dressings in deep burns, the healing times were nanocrystalline silver (16 days) and silver carboxymethylcellulose (21 days). CONCLUSIONS Results of our retrospective study would suggest that paraffin gauzes are a valuable option in superficial burns, while silver-based dressings are preferable in deep burns. RECONSTRUCTIVE SURGERY

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Section: Table 5 Healing Times For the Different Dressings Used Accorsupporting

confidence: 87%

Section: Table 5 Healing Times For the Different Dressings Used Accormentioning

confidence: 99%

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Gravante

Montone

2010

annals

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show abstract

“…It is a fast-acting, reliable and complication-free enzymatic debriding agent that is capable of lysing the burn eschar within 4 h. Interestingly, bromelain removes necrotic tissue without damaging the normally healing underlying wound [6][7][8][9]. A pilot study showed that collagenase and polymyxin B sulfate may have a superior effect when compared to silver sulfadiazine alone [10]. Other modalities such as collagenase clostridiopeptidase A (CCA), [11] an ananain-based, cysteine protease preparation [12] and vibriolysin [13] have been reported in the literature with encouraging outcomes.…”

Section: Discussionmentioning

confidence: 99%

Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds

Hafezi

Rad

Naghibzadeh

et al. 2010

Burns

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“…The initial treatment of partial thickness burns is debridement and coverage with a topical agent that provides antibacterial coverage and allows for burn eschar separation [2][3][4][5]. The long-term sequelae of burns in children can be immense with lifelong implications.…”

Section: Discussionmentioning

confidence: 99%

Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial

Ostlie

Juang

Aguayo

et al. 2012

Journal of Pediatric Surgery

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Collagenase Ointment and Polymyxin B Sulfate/Bacitracin Spray Versus Silver Sulfadiazine Cream in Partial-Thickness Burns: A Pilot Study

Cited by 57 publications

References 0 publications

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

A retrospective analysis of ambulatory burn patients: focus on wound dressings and healing times

Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds

Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial

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