Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds

Hafezi, Farhad; Rad, Hamid Elmi; Naghibzadeh, Bijan; Nouhi, A H; Naghibzadeh, Ghazal

doi:10.1016/j.burns.2009.04.021

Cited by 33 publications

(15 citation statements)

References 17 publications

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“…In a similar study, Hafezi et al demonstrated that eschar sloughing in kiwi and control group were 20 and 30-42 days, respectively. Subsequently, kiwifruit significantly accelerated eschar sloughing compared with control group (14).…”

Section: Discussionmentioning

confidence: 90%

Topical effectiveness of kiwifruit versus fibrinolysin ointment on removal of necrotic tissue of full-thickness burns in male rats

et al. 2012

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Formation of necrotic tissues is a major issue affecting treatment of full-thickness burns. This study was designed to compare topical effectiveness of applying kiwifruit versus fibrinolysin on removal of necrotic tissue of burns. Ten adult male Wistar rats were randomly assigned to three groups. For group 1, the right-side wounds were treated with kiwifruit and the other side with fibrinolysin. For group 2, the wounds on the right side were treated with kiwifruit or fibrinolysin, and the left sides were kept as control group 2. All wounds in group 3 were considered as control group 1. The control wounds were left to heal naturally. In each group and for each wound, the time of debridement were noted. The results indicated that for the wounds where kiwifruit was applied, the average time for removal of dead tissue was 5.7 days, which is significantly shorter than the average 18.5 days it took for treatment with fibrinolysin (p = 0.02). However, there were no significant differences between control wounds 1 and 2. Findings of the present study can open new horizons and provide a new treatment modality for patients with deep burns.

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Section: Discussionmentioning

confidence: 90%

Topical effectiveness of kiwifruit versus fibrinolysin ointment on removal of necrotic tissue of full-thickness burns in male rats

et al. 2012

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“…For the enzymebased debridement of wounds, this continuous release profile with constant enzyme supply is advantageous as necrotic tissue is degraded continuously. Beside Krillase ® [15,46], the hollow fibre technique presented here would also be favourable for other approaches of enzymatic debridement like streptokinase/streptodornase [47], debrase/debridase [48], collagenase [49] or new plant-derived enzymes [50]. It is likely that the listed debriding enzymes interact in a similar way with the inner walls of cellulosic hollow fibres as the Krill enzyme Krillase ® .…”

Section: Discussionmentioning

confidence: 99%

“…Hence, storage of these ingredients by freeze-drying would favourably allow not only long-term availability of the active debriding principle at the wound surface, but also drug-delivery without further chemical preservatives. The technique presented here is advantageous compared to soaking dressings with drugs [47] or applying raw natural substances [50] with regard to the production of dressings and their bed-side application and thus holds the potential to improve active wound therapy by a ready-to-use wound dressing.…”

Section: Discussionmentioning

confidence: 99%

A Novel In Situ Self-Dissolving Needle Web Based on Medicated Cellulose Hollow Fibres with Drug Delivery Features

Hoefer¹,

Hohn²,

Berner-Dannenmann³

et al. 2011

TOMDJ

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Medicated wound dressings incorporate chemicals which have therapeutic value. The objective of this study was to investigate the in vitro model drug release from a biodegradable needle web, based on medicated cellulosic hollow fibres, which self-dissolve in the presence of aqueous solutions. Cellulose hollow fibres were prepared by a standard dry-wet phase inversion spinning process. Dressings were made using established techniques in the nonwoven industry. Two sets of hollow fibres were filled with different drug solutions: One set contained the enzyme cellulase and the second set was filled with either antibacterial Pseudomonas aeruginosaspecific bacteriophages, or the wound debriding enzyme Krillase ®. Both fibre sets were freeze-dried to (i) inactivate the spontaneous biodegradation of the fibres by cellulase and (ii) to preserve the wound healing activities of the biotherapeutic model drugs. Needle webs containing different mixing ratios of the two sets of hollow fibres were made. Whereas bacteriophages were released after rewetting the webs in in-vitro experiments with high burst effect, Krillase ® showed a sustained drug release over 20 h, which was found to be dependent on the mixing ratio of cellulase versus Krillase ®-hollow fibres. Possible release mechanisms and therapeutic benefits are discussed. In summary, needle webs of medicated cellulosic hollow fibres are a new self-dissolving drug delivery system.

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“…They reported that debridement, neo-epithelialization and scar contraction were faster in the kiwi-treated group than in the untreated group. Following rapid enzymatic debridement, healing appeared to progress normally, with no evidence of damage to the adjacent healthy tissue [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Wound Dressing with Fresh Kiwifruit on healing of Cutaneous Wound in Rats

Goudarzi

Lashkarbolouki

Khorshidi

et al. 2015

Zahedan J Res Med Sci

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Background:The kiwi fruit is known to have dramatic antibacterial, debridement, wound contracture, and angiogenic effects. We propose that kiwifruit is an ideal candidate to enhance the process of wound healing. The present study assessed the effects of wound kiwifruit dressing on cutaneous wound healing in rat. Materials and Methods: In this experimental study, 30 male Wistar rats were randomly divided into 2 groups of control and kiwifruit group. A full-thickness dermal incision (35mm length) was made on the right side of the paravertebral region. In the control group, one day after wound induction wounds was dressed with Vaseline sterile gauze after normal saline irrigation. In the second group, the wounds were dressed with kiwifruit. Wound healing was evaluated by measuring surface area, percentage of healing, duration of healing, and wound tensile strength. Results: Obtained results showed that the duration of wound healing in kiwi group in comparison with the control was significantly decreased. The amount of wound healing in percent was also significantly different between control and kiwi groups at days 3, 6 (p<0.001), 9 (p<0.05), 12 and 14 (p<0.01). Comparisons of wound length between control and kiwi group per day showed that kiwi group had significantly lower wound length on day 9, 12, 14 and 16 (p<0.01, 0.001, 0.01 and 0.01, respectively) in comparisons to control group. Also, the wound tensile strength in kiwi group also was significantly greater than the control animals (p<0.01). Conclusion:We concluded that our study provides some evidence to support the use of kiwi to accelerate wound healing.

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Actinidia deliciosa (kiwifruit), a new drug for enzymatic debridement of acute burn wounds

Cited by 33 publications

References 17 publications

Topical effectiveness of kiwifruit versus fibrinolysin ointment on removal of necrotic tissue of full-thickness burns in male rats

Topical effectiveness of kiwifruit versus fibrinolysin ointment on removal of necrotic tissue of full-thickness burns in male rats

A Novel In Situ Self-Dissolving Needle Web Based on Medicated Cellulose Hollow Fibres with Drug Delivery Features

Effect of Wound Dressing with Fresh Kiwifruit on healing of Cutaneous Wound in Rats

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