Collagen metabolism in skin and periodontal membrane of the marmoset

Skougaard, M. R.; Levy, Barnet M.; Simpson, J.

doi:10.1111/j.1600-0722.1970.tb02072.x

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…The number and staining intensity of CB-IR periodontal fibroblasts increased gradually with the passage of time. Previous biochemical and autoradiographic studies have revealed that the turnover rate of periodontal ligament collagen is one of the most rapid in the whole body (Skougaard et al 1970;Sodek and Ferrier 1988), suggesting that the periodontal fibroblasts are at an active stage in response to mechanical forces such as physiological tooth movement and occlusion. Due to functions such as the buffering of intracellular calcium concentrations and cytoprotective effects, CB may play an important role in homeostasis and survival of the periodontal fibroblasts against mechanical forces caused by constant occlusion.…”

Section: Fig 5a-h Photomicrographs Of Keratin-li (A C E G) and Cbmentioning

confidence: 99%

Immunohistochemical localization of calbindin D28k during root formation of rat molar teeth

Onishi

Ooshima

Sobue

et al. 1999

Cell and Tissue Research

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The present study was undertaken to examine the localization of calbindin D28k (CB)-like immunoreactivity (-LI) during the root formation of the rat molar. In the adult rat, CB-LI was detected in some of the cells of the epithelial rest of Malassez at the bifurcational region and in certain cells between the root dentin and cementum at the apical region. These cells had indented nuclei and many tonofilaments, and cementocytes lacked CB-LI. Moreover, CB-LI was observed in the periodontal fibroblasts in the alveolar half of the apical region. During root formation, the cells in the Hertwig's epithelial root sheath (HERS) lacked CB-LI, but most fragmented cells along the root surface began to express CB-LI when HERS was disrupted. Preodontoblasts and odontoblasts at the apical portion of the root also showed CB-LI. After the formation of cellular cementum, the CB-immunoreactive (-IR) cells were entrapped between the root dentin and cementum in the apical portion of the root. The number of CB-IR cells at the root surface decreased gradually, while that between the root dentin and cementum increased. The fibroblasts in the periodontal ligament began to express CB-LI after commencement of the occlusion, and the number and the staining intensity of CB-IR fibroblasts increased gradually with the passage of time. The present results suggest that CB may play an important role in the survival of the epithelial cells, in the cellular responses of periodontal fibroblasts against mechanical forces caused by the occlusion, and in the initial mineralization by the odontoblasts through the regulation of intracellular Ca(2+) concentration.

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Section: Fig 5a-h Photomicrographs Of Keratin-li (A C E G) and Cbmentioning

confidence: 99%

Immunohistochemical localization of calbindin D28k during root formation of rat molar teeth

Onishi

Ooshima

Sobue

et al. 1999

Cell and Tissue Research

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“…and for this would seem to require some One possible approach to this problem is degree of tensile strength. At the same time to determine the rate of periodontal ligaa considerable amount of tooth movement ment collagen turnover, and some metabolic occurs during function, and whereas the studies have been carried out (Stallard 1963,, Crumley 1964, Cameiro & Fava de Moraes 1965, Skougaard, Frandsen & Baker 1970, Skougaard, Levy & Simpson 1970 but their results are at best only semi-quantitative, mainly because the required activity-time curves were not constructed. The usual biochemical and radiochemical methods of measuring turnover times are not readily applicable to the periodontal ligament because of difficulty in obtaining the required tissue samples.…”

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confidence: 99%

Collagen turnover in the periodontal ligament under normal and altered functional forces

Rippin

1978

J of Periodontal Research

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48 six month old rats were given 1 μCi/g of body weight of tritiated proline by intraperitoneal injection, 24 of them having had the left maxillary molars extracted two weeks earlier; 4 animals from each group were killed after a further 12 hours, 1, 4, 7, 12 or 20 days. Analyses of autoradiographic grain densities in various areas of the lower first molar periodontal ligament allowed calculation of half‐lives which were attributable to collagen turnover; all such values were less than 12 days. It is argued that the results are applicable to man in relative terms and thus have several important clinical implications. It becomes entirely feasible that the tissue destruction in chronic periodontitis is, at least in part, a function of decreased collagen formation brought about by any inflammatory process. The normal relatively slow rate of turnover in crestal fibres may well provide a barrier to the spread of inflammation from the gingiva, but its increase consequent on incresed tooth movement, as occurs in active orthodontic treatement, may reduce the barrier's effectiveness. However, the turnover rate is such taht even in adults it should not be a limiting factor in orthodontic treatement or in periodontal treatment aimed at restorring attachement.

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“…This is readily explicable in the case of Ten Gate's study ol 1972, as he specifically examined regions in which there was continuous breakdown or remodelling of connective tissue. Age may be a factor; for Listgarteii (1973) used young rodents, and collagen metabolism has been found to be greater in young than in old animals (Skougaard, Levy & Simpson 1970). However, Ten Cate & Deporter (1974) used adult mice, and also mentioned that Melcher had found intraceliular collagen in the periodontal ligament of aged rats, whereas 5 of the 6 periodontal ligaments of the present investigation were from young patients.…”

Section: Eley and Harrisonmentioning

confidence: 57%