Collagen dressing versus conventional dressings in burn and chronic wounds: A retrospective study

Abstract

Objective:Biological dressings like collagen are impermeable to bacteria, and create the most physiological interface between the wound surface and the environment. Collagen dressings have other advantages over conventional dressings in terms of ease of application and being natural, non-immunogenic, non-pyrogenic, hypo-allergenic, and pain-free. This study aims to compare the efficacy of collagen dressing in treating burn and chronic wounds with that of conventional dressing materials.Materials and Methods:The records of 120 patients with chronic wounds of varied aetiologies and with mean age 43.7 years were collected and analyzed. The patients had been treated either with collagen or other conventional dressing materials including silver sulfadiazine, nadifloxacin, povidone iodine, or honey (traditional dressing material). Patients with co-morbidities that could grossly affect the wound healing like uncontrolled diabetes mellitus, chronic liver or renal disease, or major nutritional deprivation were not included. For the purpose of comparison the patients were divided into two groups; ‘Collagen group’ and ‘Conventional group’, each having 60 patients. For assessment the wound characteristics (size, edge, floor, slough, granulation tissue, and wound swab or pus culture sensitivity results) were recorded. With start of treatment, appearance of granulation tissue, completeness of healing, need for skin grafting, and patients’ satisfaction was noted for each patient in both groups.Results:With two weeks of treatment, 60% of the ‘collagen group’ wounds and only 42% of the ‘conventional group’ wounds were sterile (P=0.03). Healthy granulation tissue appeared earlier over collagen-dressed wounds than over conventionally treated wounds (P=0.03). After eight weeks, 52 (87%) of ‘collagen group’ wounds and 48 (80%) of ‘conventional group’ wounds were >75% healed (P=0.21). Eight patients in the ‘collagen group’ and 12 in the ‘conventional group’ needed partial split-skin grafting (P=0.04). Collagen-treated patients enjoyed early and more subjective mobility.Conclusion:No significant better results in terms of completeness of healing of burn and chronic wounds between collagen dressing and conventional dressing were found. Collagen dressing, however, may avoid the need of skin grafting, and provides additional advantage of patients’ compliance and comfort.

A Comparative Study of Collagen Dressings Versus Conventional Dressings in Wound Healing in Chronic Ulcer

“…This finding was comparable to other studies, i.e. Veves et al, 4 Singh O et al 6 and Rao et al 5 Need of grafting was more in conventional group as compared to collagen in present study as well as studies by Singh O et al 6 and Rao H et al 5 …”

“…Average age in studies done by Veves et al 4 and Rao et al 5 were comparable to our study, but average age in study by Singh O et al 6 was less than that included in our study, as most of the patients in our studies belonged to low socioeconomic status and were labourers by occupation even in older ages.…”

Collagen membrane for reconstruction of soft tissue defects after surgery of oral cancer and precancer: a brief review

“…It is commonly used in the management of burns, [6] diabetic foot ulcer, [7,8] toxic epidermal necrolysis, [9] chronic wounds, etc. [10][11][12] This versatile material also finds its application in the field of plastic surgery, oral and maxillofacial surgery and dentistry for various purposes e.g. as an interpositional graft material during palatoplasty; [13] for guided bone regeneration during maxillary sinus lift; [14] for inducing bone formation along with/without certain medicaments like gusuibu; [15,16] bone augmentation of posterior atrophic mandibular ridge for placement of dental implants; [17] as a reconstructive material for orbital floor fractures; [18] in treatment of localized gingival recession; [19] as a scaffold in tissue engineering to generate dental pulp; [20] for coverage of small intraoral soft tissue defects of the oral cavity [21] and much more.…”

Multifunctional materials for bone cancer treatment

“…[80][81][82] Once extracted, the native or denatured collagen can be stored as gel or transformed in fibers or matrices. 77 It is worth mentioning that type I collagen is also com mercially available and used as wound dressing, especially in the case of burns, 83,84 as a main component of many creams designed for care or treatment of skin laxity, rhytides, or photoaging, 85 or as a component of many engineered materi als used for bone regeneration and cancer treatment. 70,78,86,87 Collagen has also been used since 1980 as a drugdelivery system for ophthalmic agents (especially the antibiotics gentamicin and vancomycin), 88 the trend being to extend the use of this material in obtaining many other drugdelivery systems.…”