Multifunctional materials for bone cancer treatment

Abstract

The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen–hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

Microbial Production of Violacein and Process Optimization for Dyeing Polyamide Fabrics With Acquired Antimicrobial Properties

“…Textiles have evolved from being just commodity materials to providing an array of benefits, including additional comfort and protection, improved hygiene, and supporting healthcare. The textile industry has shown great interest toward the manufacturing of smart multifunctional fabrics oriented for medical applications ( Carosio and Monero, 2004 ; Marques et al, 2014 ; Armstrong et al, 2017 ). In particular, there is great interest in obtaining fabrics with antimicrobial properties capable of controlling the spread of multiresistant microorganisms.…”

Targeting tumor metastases: Drug delivery mechanisms and technologies

“…Drug delivery to bone has been accomplished frequently in the context of biomaterials serving as bone grafts while delivering therapeutics; this approach is suitable for established bone neoplasms [121]. The fenestrated architecture of bone may allow penetration of nanoparticles with an extended circulation time, as has been shown, for example, in antisense delivery with PLGA particles [122].…”

Advances in Cancer Treatment: Role of Nanoparticles

“…Complex systems based on magnetic core, different shells, and tumoral receptors are of great importance. The locoregional drug delivery systems are well known to be beneficial because the systemic toxicity can be reduced compared with the other administration routes [4,10,14]. The targeted delivery is very useful especially when local administration is not possible.…”

“…Bone cancer treatment is a real challenge in this century. It affects especially children and young people/teenagers (10-20 years) -up to 4-7% of all cancers -and rarely appears in old people (less than 0.2% of all cancers) [10][11][12]. Malignant primary bone tumors are usually associated with an aggressive growth [12].…”