“…Cold haemagglutinins are found in human sera in a wide range of pathological conditions, including acquired haemolytic anaemia, atypical pneumonia, some acute bacterial infections, cirrhosis of the liver, trypansomiasis (Stats and Wasserman, 1943), lymphoma, and the tropical hypergamma-globulinaemia occurring in the peoples of the lowland areas of New Cuinea and New Britain (Curtain, Baumgarten, Kidson, Corman, Rodrigue, Champness and Cajdusek, 1965). Cordon (1953) demonstrated that cold haemagglutinins eluted from the erythrocytes in a case of acquired haemolytic anaemia were 19S macroglobulins.…”