Cold atmospheric plasma – A new technology for spacecraft component decontamination

Shimizu, Satoshi; Barczyk, Simon; Rettberg, Petra; Shimizu, Tetsuji; Klaempfl, Tobias; Zimmermann, Julia L.; Hoeschen, T.; Linsmeier, Ch.; Weber, P. K.; Morfill, G. E.; Thomas, Hubertus M.

doi:10.1016/j.pss.2013.10.008

Cited by 31 publications

(27 citation statements)

References 50 publications

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“…Unlike other gaseous or airborne decontaminants, SMD air plasma consists of a mixture of reactive oxygen and nitrogen species (RONS), charged species and UV light . Former studies showed that SMD air plasma is effective in inactivating bacteria, fungal biofilms, viruses, and bacterial endospores …”

Section: Introductionmentioning

confidence: 99%

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Klämpfl

Shimizu

Koch

et al. 2014

Plasma Process. Polym.

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Microbial control is important to prevent nosocomial infections. Cold atmospheric plasma (CAP) is studied as an alternative disinfectant for dry surfaces. Bacterial endospores including Clostridium difficile and vegetative bacteria including Enterococcus faecium are treated on carriers, considering European testing standards. CAP reduces the spore load (106 cfu) by at least 3 log10 as required, independent from the bioburden (≤10 min treatments). Only a 2 log10 reduction is achieved with vegetative bacteria due to multilayer formation resulting from a higher required load (108 cfu). However, densities <10−7 cfu cm−2 enable disinfection by CAP. Elemental mapping identified other influencing burden. Overall, this study demonstrates possibilities and limitations of CAP treatment for disinfecting purposes.

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Section: Introductionmentioning

confidence: 99%

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Klämpfl

Shimizu

Koch

et al. 2014

Plasma Process. Polym.

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“…[121] Spore Bacillus thuringiensis E24. [122,123] Studies have shown CAP has effective sporicidal action even in humid conditions [124,125] , when spores are stacked together or covered by debris.…”

Section: Mechanisms Of Microbial Inactivation By Capmentioning

confidence: 99%

“…[154] CAP can easily reach narrow, confined spaces and microgrooves on surfaces. [82] and mobility of plasma gas can allow for treatment of microspaces [123,155] . Recent studies reported CAP efficacy in reducing microbial contamination adhered to rough surfaces of chicken skin [151] , titanium implant surfaces [156] and root canals, especially in dry state conditions.…”

Section: Cap As a Potential Technique For Thin Tissue Sterilizationmentioning

confidence: 99%

“…Skin flora Coated glass slides 7 log 600 [121] Deinococcus radiodurans Radiation, drying and oxidizing agent resistant Aluminium discs 3 log 1,800 [123] Lactobacillus acidophilus…”

Section: Propionibacterium Acnes Kctc 3314mentioning

confidence: 99%

“…Sterilization resistant Aluminium discs ˃ 3 log 5,400 [123] Bacillus subtilis Sterilization resistant…”

Section: Bacillus Thuringiensis Dsm 30879 (E24)mentioning

confidence: 99%

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Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Marsit

Sidney

Branch

et al. 2016

Plasma Processes & Polymers

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Tissue products are susceptible to microbial contamination from different sources, which may cause disease transmission upon transplantation. Terminal sterilization using gamma radiation, electron‐beam, and ethylene oxide protocols are well‐established and accepted, however, such methods have known disadvantages associated with compromised tissue integrity, functionality, safety, complex logistics, availability, and cost. Non‐thermal (cold) atmospheric pressure plasma (CAP) is an emerging technology that has several biomedical applications including sterilization of tissues, and the potential to surpass current terminal sterilization techniques. This review discusses the limitations of conventional terminal sterilization technologies for biological materials, and highlights the benefits of utilizing CAP.

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Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO₃ After Cold Atmospheric Plasma Treatment

Bartis

Luan

Knoll

et al. 2015

Plasma Processes & Polymers

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Cold atmospheric plasma (CAP) treatment of biological surfaces results in important changes of biological functions, but little knowledge on specific surface-chemical changes is available. We measured surface-bound NO 3 on polymer and biomolecular films after CAP treatment. An O 2 /N 2 -based surface microdischarge was used to deactivate lipopolysaccharide (LPS), an immune-stimulating biomolecule found in Gram negative bacteria. The observed LPS biodeactivation was highest for low N 2 concentrations in O 2 , increased roughly linearly with surface NO 3 , and then saturated. NO 3 was also observed after treatment by a very different source: an atmospheric pressure plasma jet operating with an Ar carrier gas. Thus, NO 3 formation is a generic surface chemical modification of these materials by CAP sources.

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Cold atmospheric plasma – A new technology for spacecraft component decontamination

Cited by 31 publications

References 50 publications

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO₃ After Cold Atmospheric Plasma Treatment

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Cold atmospheric plasma – A new technology for spacecraft component decontamination

Cited by 31 publications

References 50 publications

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Decontamination of Nosocomial Bacteria IncludingClostridium difficileSpores on Dry Inanimate Surface by Cold Atmospheric Plasma

Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO3 After Cold Atmospheric Plasma Treatment

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Product

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Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO₃ After Cold Atmospheric Plasma Treatment