Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Marsit, Nagi M.; Sidney, Laura E.; Branch, Matthew J.; Wilson, Samantha L.; Hopkinson, Andrew

doi:10.1002/ppap.201600134

Cited by 21 publications

(22 citation statements)

References 177 publications

(334 reference statements)

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“…Its efficacy has been successfully demonstrated against viruses that cause foodborne illness such as norovirus as well as viruses that cause respiratory illness, including influenza, adenovirus, and respiratory syncytial virus, where NTP prevented viral replication and transmission. [ 78–85 ]…”

Section: Nonthermal Plasma (Ntp) As An Immunogenic Cell Death Inducermentioning

confidence: 99%

Nonthermal plasma as part of a novel strategy for vaccination

Mohamed

Esposito

Kutzler

et al. 2020

Plasma Processes & Polymers

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Vaccination has been one of the most effective health intervention mechanisms to reduce morbidity and mortality associated with infectious diseases. Vaccines stimulate the body's protective immune responses through controlled exposure to modified versions of pathogens that establish immunological memory. However, only a few diseases have effective vaccines. The biological effects of nonthermal plasma on cells suggest that plasma could play an important role in improving efficacy of existing vaccines and overcoming some of the limitations and challenges with current vaccination strategies. This review summarizes the opportunities for nonthermal plasma for immunization and therapeutic purposes.

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Section: Nonthermal Plasma (Ntp) As An Immunogenic Cell Death Inducermentioning

confidence: 99%

Nonthermal plasma as part of a novel strategy for vaccination

Mohamed

Esposito

Kutzler

et al. 2020

Plasma Processes & Polymers

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“…Nonthermal plasma, which is produced at low pressure, is convenient and economically effective; it is used in human medicine and is called CAP. CAP is effective in removing micro‐organisms 10–12 . Through the action of reactive oxygen species and reactive nitrogen species released during plasma generation, CAP damages the bacterial cell wall and causes high oxidative stress and cell membrane rupture.…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial activity of cold atmospheric microwave plasma against bacteria causing canine skin and ear infections

Jin

Hwang

Kang³

et al. 2021

Veterinary Dermatology

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Background Cold atmospheric plasma (CAP) is a new generation medical therapeutic option for bacterial infections. CAP causes physical cell wall rupture and DNA damage, therefore making it highly useful in the treatment of various conditions such as skin infections. Hypothesis/objectives The antimicrobial activity of cold atmospheric microwave plasma (CAMP) against major strains in canine skin infections was tested and the difference in antimicrobial activity between the antibiotic‐resistant and antibiotic‐susceptible strains of Staphylococcus pseudintermedius was evaluated. Methods and materials American Type Culture Collection (ATCC) strains (Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli) and clinical isolates identified as methicillin‐resistant S. pseudintermedius (n = 27) and methicillin‐susceptible S. pseudintermedius (n = 13) were exposed to CAMP for 10 s, 30 s and 60 s. Afterwards, the bacterial survival rate was confirmed. Results Gram‐negative bacteria (P. aeruginosa and E. coli) were more susceptible than Gram‐positive bacteria (S. aureus and S. pseudintermedius) for the same duration of CAMP exposure. Only the Gram‐negative bacteria were completely killed after 60 s exposure. In S. pseudintermedius isolates, CAMP exposure had similar antibacterial effects regardless of antibiotic resistance. Conclusions and clinical importance CAMP has sufficient antimicrobial activity against major bacterial strains that cause pyoderma and otitis externa in dogs, and may be an alternative therapeutic option for S. pseudintermedius skin infections, for which antibiotics often are ineffective because of antimicrobial resistance in clinical veterinary medicine.

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“…Thus, for plasma‐treated solutions such as saline solution or water, suitable medical applications are conceivable . This comprises the decontamination of tissues like ocular surface tissues e.g., corneal transplants . In several medical and environmental settings, proteins and consequently amino acids are naturally present.…”

Section: Introductionmentioning

confidence: 99%

Plasma‐mediated inactivation of E. coli: Influence of protein on wet surface and in liquid medium

Hahn

Dikyol

Altrock

et al. 2019

Plasma Processes & Polymers

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Application of cold atmospheric-pressure plasma (CAP) for wound treatment and decontamination of food or water often includes the presence of proteins. These proteins contain amino acids with functional groups, such as thiol (SH) groups. Plasma-mediated effects in biological systems involve reactive oxygen and nitrogen species. In this regard, redox signaling is often mediated via thiol groups. The aim of this study was to investigate the influence of a protein and an SH group containing amino acids on the antimicrobial properties of plasmatreated saline solution (0.85% NaCl, w/v) and on the direct CAP efficacy on solid wet agar plates. Plasma treatment of saline solution was realized using an ACdriven pin-to-liquid discharge. After plasma treatment for 10 minutes, the amino acids L-cysteine (contains SH group) or L-alanine (no SH group) or bovine serum albumin (BSA; with approximately 6% cysteine content) were added together with the test microorganism Escherichia coli K-12 (DSM 11250/ NCTC 10538) for an exposure time of up to 60 min. The total viable cell count was determined at appropriate time intervals. A concentration-dependent repeal of the antimicrobial efficacy was determined. Therefore, 0.0025% of BSA did not have any influence, whereas 0.25% of BSA w/v, as well as the tested amino acids, did not result in the inactivation of E. coli. The difference between L-alanine and L-cysteine was negligible, suggesting only a minor effect of the presence of SH groups. Dimerization of L-cysteine was shown by LC/MS analyses, whereas no derivatization of L-alanine was detected. To test the influence of proteins in direct plasma treatment on wet surfaces, E. coli was plated together with BSA on soybean-casein digest agar surface. Another setup was based on agar plates, which contained different concentrations of peptone (a mixture of peptides and amino acids). The agar plates were regularly treated by the argon-driven CAP jet kINPen Med (neoplas tools GmbH, Greifswald, Germany). After overnight incubation, inhibition zones were analyzed. The bacterial growth was independent of protein or peptone content for this direct plasma treatment. Summarizing all, the antibacterial effect of the Plasma Process Polym. 2019;16:e1800164 www.plasma-polymers.com

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Terminal sterilization: Conventional methods versus emerging cold atmospheric pressure plasma technology for non‐viable biological tissues

Cited by 21 publications

References 177 publications

Nonthermal plasma as part of a novel strategy for vaccination

Nonthermal plasma as part of a novel strategy for vaccination

In vitro antimicrobial activity of cold atmospheric microwave plasma against bacteria causing canine skin and ear infections

Plasma‐mediated inactivation of E. coli: Influence of protein on wet surface and in liquid medium

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