Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)

Matheson, Melanie C.; Abramson, Michael J.; Allen, Katrina J.; Benke, Geza; Burgess, John A.; Dowty, James G.; Erbas, Bircan; Feather, Iain; Frith, Peter; Giles, Graham G.; Gurrin, Lyle; Hamilton, Garun S.; Hopper, John L.; Jenkins, Mark A.; Johns, DP; Lodge, Caroline; Lowe, Adrian J.; Markos, James; Morrison, Stephen; Perret, Jennifer L; Southey, Melissa C.; Thomas, Paul S.; Thompson, Bruce; Wood‐Baker, Richard; Walters, E. Haydn; Dharmage, Shyamali C.

doi:10.1093/ije/dyw028

Cited by 40 publications

(64 citation statements)

References 22 publications

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“…Our study included participants from 2002 –2008 and 2010 –2012 follow-up surveys of the Tasmanian Longitudinal Health Study (TAHS) for which methodology and previous results have been published elsewhere 19. Briefly, TAHS began in 1968 by recruiting all 8583 school children born in 1961 in Tasmania.…”

Section: Methodsmentioning

confidence: 99%

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Occupational exposure to solvents and lung function decline: A population based study

Alif

Dharmage

Benke

et al. 2019

Thorax

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RationaleWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements.ObjectivesWe aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study.MethodsLung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status.ResultsCompared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI −24.8 to 6.3); metals 11.3 mL/year (95% CI −21.9 to – 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI −28.8 to – 0.7; metals 17.5 mL/year (95% CI –34.3 to – 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function.ConclusionsExposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

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Section: Methodsmentioning

confidence: 99%

“…(figure 1). 19 In the current analysis, we included 767 participants who completed lung function at both follow-ups and a lifetime work history calendar during the 2002–2008 follow-up study. All participants provided written informed consent.…”

Section: Methodsmentioning

confidence: 99%

Occupational exposure to solvents and lung function decline: A population based study

Alif

Dharmage

Benke

et al. 2019

Thorax

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“…We included participants from the 2002 to 2008 follow-up of the population-based Tasmanian Longitudinal Health Study (TAHS), details of which have been reported elsewhere,15 and are summarised in figure 1. Briefly, TAHS started in 1968 when all children aged 7 years (n=8583) attending school in Tasmania were enrolled in a study of asthma.…”

Section: Methodsmentioning

confidence: 99%

Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Alif

Dharmage

Benke

et al. 2017

Thorax

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“…The methods for the baseline and subsequent follow-up studies have been published [20,32,36,37,38,39,40]. Briefly, the participants (otherwise known as “probands”) who were born in 1961 and schooled in Tasmania in 1968 ( n = 8583 (99%)) were studied by questionnaires and spirometry when seven-years old.…”

Section: Methodsmentioning

confidence: 99%

“…For a subset of these participants ( n = 837), additional data on history of cardiovascular events was obtained from the 2010 clinical study (see definition of cardiovascular risk). These main components of the study design have been illustrated in Figure 1 and in reference [39], Figure 1 on page 4.…”

Section: Methodsmentioning

confidence: 99%

The Dose–Response Association between Nitrogen Dioxide Exposure and Serum Interleukin-6 Concentrations

Perret

Bowatte

Lodge

et al. 2017

IJMS

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Systemic inflammation is an integral part of chronic obstructive pulmonary disease (COPD), and air pollution is associated with cardiorespiratory mortality, yet the interrelationships are not fully defined. We examined associations between nitrogen dioxide (NO2) exposure (as a marker of traffic-related air pollution) and pro-inflammatory cytokines, and investigated effect modification and mediation by post-bronchodilator airflow obstruction (post-BD-AO) and cardiovascular risk. Data from middle-aged participants in the Tasmanian Longitudinal Health Study (TAHS, n = 1389) were analyzed by multivariable logistic regression, using serum interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α) as the outcome. Mean annual NO2 exposure was estimated at residential addresses using a validated satellite-based land-use regression model. Post-BD-AO was defined by post-BD forced expiratory ratio (FEV1/FVC) < lower limit of normal, and cardiovascular risk by a history of either cerebrovascular or ischaemic heart disease. We found a positive association with increasing serum IL-6 concentration (geometric mean 1.20 (95% CI: 1.1 to 1.3, p = 0.001) per quartile increase in NO2). This was predominantly a direct relationship, with little evidence for either effect modification or mediation via post-BD-AO, or for the small subgroup who reported cardiovascular events. However, there was some evidence consistent with serum IL-6 being on the causal pathway between NO2 and cardiovascular risk. These findings raise the possibility that the interplay between air pollution and systemic inflammation may differ between post-BD airflow obstruction and cardiovascular diseases.

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Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)

Cited by 40 publications

References 22 publications

Occupational exposure to solvents and lung function decline: A population based study

Occupational exposure to solvents and lung function decline: A population based study

Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

The Dose–Response Association between Nitrogen Dioxide Exposure and Serum Interleukin-6 Concentrations

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