Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Alif, Sheikh M; Dharmage, Shyamali C.; Benke, Geza; Dennekamp, Martine; Burgess, John A.; Perret, Jennifer L; Lodge, Caroline; Morrison, Stephen; Johns, DP; Giles, Graham G.; Gurrin, Lyle C.; Thomas, Paul S.; Hopper, John L.; Wood‐Baker, Richard; Thompson, Bruce; Feather, Iain; Vermeulen, Roel; Kromhout, Hans; Walters, E. Haydn; Abramson, Michael J.; Matheson, Melanie C.

doi:10.1136/thoraxjnl-2016-209665

Cited by 47 publications

(39 citation statements)

References 30 publications

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“…Biological dust has been shown to affect lung function decline and chronic respiratory symptoms in several worker-based studies such as in farmers, cotton textile and woodworkers 33–36. An association with COPD prevalence has also been demonstrated in a community-based cross-sectional study26 and recently in another one from Australia 37. To our knowledge, this is the first study to demonstrate an effect of biological dust exposure on the incidence of COPD in a prospective fashion in a general population cohort.…”

Section: Discussionsupporting

confidence: 64%

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Lytras

Kogevinas

Kromhout

et al. 2018

Thorax

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Section: Discussionsupporting

confidence: 64%

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Lytras

Kogevinas

Kromhout

et al. 2018

Thorax

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“…Job Exposure Matrices (JEMs) provide some protection from these types of bias, because they are applied consistently to reported job titles and do not rely on self-assessed exposures. Furthermore, JEM applied to complete work history calendars can assess lifetime exposures capturing multiple jobs and job transitions over the life course 17. However, few population-based studies have used JEM to investigate the associations between occupational exposures and lung function decline over time, and none have investigated exposures to solvents and decline of lung function 2 8 18…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to solvents and lung function decline: A population based study

Alif

Dharmage

Benke

et al. 2019

Thorax

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RationaleWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements.ObjectivesWe aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study.MethodsLung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status.ResultsCompared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI −24.8 to 6.3); metals 11.3 mL/year (95% CI −21.9 to – 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI −28.8 to – 0.7; metals 17.5 mL/year (95% CI –34.3 to – 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function.ConclusionsExposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

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“…Blanc et al developed a JEM for COPD and found associations between COPD and the overall exposure category including vapor‐gas, dust, and fumes . Some more recent studies on COPD and occupational exposure using another instrument, the ALOHA JEM, found that occupational exposure to pesticides was associated with airflow obstruction while the European Community Respiratory Health Survey found occupational exposures to biological dusts, gases and fumes, and pesticides were associated with the 20 year incidence of COPD . In addition, one United Kingdom study assessed COPD and found associations between both self‐reported and JEM‐associated exposures to vapors, gas, dust, and fumes .…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure and airflow obstruction and self‐reported COPD among ever‐employed US adults using a COPD‐job exposure matrix

Doney

Kurth

Halldin

et al. 2019

American J Industrial Med

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Introduction This study examined the association of spirometry‐defined airflow obstruction and self‐reported COPD defined as self‐reported doctor diagnosed chronic bronchitis or emphysema, with occupational exposure among ever‐employed US adults. Methods Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007‐2008 to 2011‐2012, a nationally representative study of the non‐institutionalized civilian US population. Reported current and/or longest held job were used to create prevalence estimates and prevalence odds ratios (PORs) (adjusted for age, gender, race, and smoking status) for airflow obstruction and self‐reported COPD by occupational exposure, determined using both NHANES participants’ self‐reported exposures and eight categories of COPD job exposure matrix (JEM) assigned exposures. Results Significant PORs for airflow obstruction and self‐reported COPD respectively were observed with self‐reported exposure for ≥20 years to mineral dust (POR = 1.44; 95% confidence interval (CI) 1.13‐1.85; POR = 1.69; 95% CI 1.17‐2.43) and exhaust fumes (POR = 1.65; 95% CI 1.27‐2.15; POR = 2.22; 95% CI 1.37‐3.58). Airflow obstruction or self‐reported COPD were also associated with COPD‐JEM assigned high exposure to mineral dust, combined dust, diesel exhaust, vapor‐gas, sensitizers, and overall exposure. Conclusion Airflow obstruction and self‐reported COPD are associated with both self‐reported and JEM‐assigned exposures.

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Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

Abstract: Pesticides and herbicides exposures were associated with fixed airflow obstruction and chronic bronchitis. Biological dust exposure was also associated with fixed airflow obstruction in non-asthmatics. Minimising occupational exposure to these agents may help to reduce the burden of COPD.

Cited by 47 publications

References 30 publications

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Occupational exposure to solvents and lung function decline: A population based study

Occupational exposure and airflow obstruction and self‐reported COPD among ever‐employed US adults using a COPD‐job exposure matrix

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