Occupational exposure to solvents and lung function decline: A population based study

Alif, Sheikh M; Dharmage, Shyamali C.; Benke, Geza; Dennekamp, Martine; Burgess, John A.; Perret, Jennifer L; Lodge, Caroline; Morrison, Stephen; Johns, DP; Giles, Graham G.; Gurrin, Lyle; Thomas, Paul S.; Hopper, John L.; Wood‐Baker, Richard; Thompson, Bruce; Feather, Iain; Vermeulen, Roel; Kromhout, Hans; Jarvis, Déborah; Aymerich, Judith García; Walters, E. Haydn; Abramson, Michael J.; Matheson, Melanie C.

doi:10.1136/thoraxjnl-2018-212267

Cited by 24 publications

(34 citation statements)

References 37 publications

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“…Upon multivariate analysis of lung function-related parameters, we discovered that FVC and FEV 1 decreased with age and was lower in participants exposed to cooking oil fumes and those who had occupational exposure, which was consistent with other studies (Alif et al 2019;Jie et al 2016). In general, healthy nonsmokers exhibit an annual decline of about 30 mL in FEV 1 per year from an age of 30 years, and FVC also decreases with age (Miller 2010;Sharma and Goodwin 2006), both of which accelerate between 65 and 93 years of age (Sorino et al 2012), forming a flow-volume cycle in which the expiratory limb is more likely to become blocked or shoveled out.…”

Section: Discussionsupporting

confidence: 91%

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China

Tian

Chen

Hou

et al. 2021

Environ Sci Pollut Res

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Our aim was to clarify the main factors associated with lung function and to analyze the correlation between fine particulate matter (PM 2.5 ) and lung function in a rural Chinese population. We analyzed data of 5195 participants in the China Northwest Natural Population Cohort: Ningxia Project who were ≥ 30 years old. They were recruited from 2018 to 2019, underwent spirometry during the physical examination, and completed a self-report questionnaire. A satellite-based spatiotemporal model was used to estimate the 2-year average PM 2.5 exposure based on participants' home addresses. A generalized linear mixed model was used to test the relationship between PM 2.5 concentration and lung function. Sex, age, exposure to cooking oil fumes, and occupational exposure were negatively correlated (P < 0.05) with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ). Educational status, economic level, tea consumption, and alcohol consumption were positively correlated (P < 0.05) with FVC and FEV 1 . The adjusted results of each model revealed that FVC and FEV 1 decreased with increased exposure to PM 2.5 . There was a strong negative correlation between a PM 2.5 concentration of 35.66 μg/m 3 and FVC, FEV1, and FEV1/FVC, with unadjusted hazard ratios of − 0.06 (95% confidence interval, − 0.10 to − 0.01), − 0.13 (− 0.17 to − 0.10), and − 22.10 (− 24.62 to − 19.26), respectively. In conclusion, long-term exposure to high concentrations of ambient PM 2.5 is related to reduce lung function among people in rural areas in northwestern China.

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Section: Discussionsupporting

confidence: 91%

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China

Tian

Chen

Hou

et al. 2021

Environ Sci Pollut Res

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“…Alif and al. observed that exposure to solvents was associated with a greater lung function decline in women than in men [21]. LeVan et al did not take into account gender and other studies only selected men [24,38].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, their use has been more rigorously regulated due to increasing knowledge about their carcinogenicity and toxicity [16,17]. Regarding lung health, some studies reported associations between exposure to solvents and respiratory symptoms [18], chronic obstructive pulmonary disease (COPD) [19] or a decrease in lung function [20][21][22]. Until now, there is limited evidence on the specific association between occupational exposures to solvents and asthma [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

Sit

Letellier

Iwatsubo

et al. 2021

IJERPH

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Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma.

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“…For example, regular use of chemical disinfectants among nurses may be a risk factor for developing COPD, 128 while men may be more exposed to agricultural insecticides and biologic dusts 129,130 . However, there is evidence, as with tobacco exposure, that women with lower cumulative exposure years to aromatic solvents than men have a greater lung function decline than men 131 . On the other hand, men are more likely to work in dusty jobs, more often unprotected, be concurrently smoking tobacco and have occupational and recreational exposure to dusts that are known to increase the prevalence of COPD.…”

Section: Is Gender Important In Copd?mentioning

confidence: 99%

Contemporary perspectives in COPD: Patient burden, the role of gender and trajectories of multimorbidity

et al. 2021

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An individual's experience of COPD is determined by many factors in addition to the pathological features of chronic bronchitis and emphysema and the symptoms that derive directly from them. Multimorbidity is the norm rather than the exception, so most people with COPD are living with a range of other medical problems which can decrease overall quality of life. COPD is caused by the inhalation of noxious particles or gases, in particular tobacco smoke, but also by early life disadvantage impairing lung development and by occupations where inhaled exposures are common (e.g. industrial, farming and cleaning work). Wealthy people are therefore relatively protected from developing COPD and people who do develop the condition may have reduced resources to cope. COPD is also no longer a condition that predominantly affects men. The prevalence of COPD among women has equalled that of men since 2008 in many high‐income countries, due to increased exposure to tobacco, and in low‐income countries due to biomass fuels. COPD is one of the leading causes of death in women in the USA, and death rates attributed to COPD in women in some countries are predicted to overtake those of men in the next decade. Many factors contribute to this phenomenon, but in addition to socioeconomic and occupational factors, there is increasing evidence of a higher susceptibility of females to smoking and pollutants. Quality of life is also more significantly impaired in women. Although most medications (bronchodilators and inhaled corticosteroids) used to treat COPD demonstrate similar trends for exacerbation prevention and lung function improvement in men and women, this is an understudied area and clinical trials frequently have a preponderance of males. A better understanding of gender‐based predictors of efficacy of all therapeutic interventions is crucial for comprehensive patient care. There is an urgent need to recognize the increasing burden of COPD in women and to facilitate global improvements in disease prevention and management in this specific population. Many individuals with COPD follow a trajectory of both lung function decline and also multimorbidity. Unfavourable lung function trajectories throughout life have implications for later development of other chronic diseases. An enhanced understanding of the temporal associations underlying the development of coexisting diseases is a crucial first step in unravelling potential common disease pathways. Lessons can be learned from exploring disease trajectories of other NCD as well as multimorbidity development. Further research will be essential to explain how early life risk factors commonly influence trajectories of COPD and other diseases, how different diseases develop in relation to each other in a temporal way and how this ultimately leads to different multimorbidity patterns in COPD. This review integrates new knowledge and ideas pertaining to three broad themes (i) the overall burden of disease in COPD, (ii) an unappreciated high burden in women and (iii) the contrast...

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Occupational exposure to solvents and lung function decline: A population based study

Cited by 24 publications

References 37 publications

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China

Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

Contemporary perspectives in COPD: Patient burden, the role of gender and trajectories of multimorbidity

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