Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

Martín-Jiménez, Paloma; Muñoz-García, Mariana I; Seoane, David; Roca-Rodríguez, Lucas; García‐Reyne, Ana; Lalueza, Antonio; Maestro, Guillermo; Folgueira, Dolores; Blanco-Palmero, Víctor Antonio; Martín, Alejandro Herrero-San; Llamas‐Velasco, Sara; Pérez-Martínez, D A; González-Sánchez, Marta; Villarejo-Galende, Alberto

doi:10.3233/jad-200937

Cited by 36 publications

(28 citation statements)

References 18 publications

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“…A total of 8 studies were further removed because they were not original articles, 2 studies were removed because the population was not in older adults with dementia who have COVID-19, 19 studies were removed because they didn't provide the result of the mortality, and 2 studies were removed because they didn't provide full-text article. Finally, 15 studies were included in the systematic review 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 . The selected studies are presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the selected studies are summarized in Table 3 , which indicates that the included studies came from 7 different countries. Six of the studies were conducted in Italy 19 , 20 , 21 , 22 , 4 were conducted in Spain 27 , 28 , 32 , 33 , and 1 study per country was conducted in Belgium 23 , France 24 , South Korea 25 , Turkey 26 , and Japan 29 .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 7 studies were analyzed to estimate the pooled prevalence rates and pooled odds ratios of mortality among older adult with dementia who have COVID-19 as compared to those without dementia with COVID-19 infection 19 , 20 , 22 , 23 , 27 , 29 , 32 . Among older adults who have COVID-19, the pooled prevalence of mortality was higher in the patients with dementia than in the patients without dementia (39%; p< 0.001 vs. 20%; p< 0.01) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

Saragih

Saragih²,

Batubara

et al. 2021

Geriatric Nursing

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The purpose of this study was to systematically examine the association between dementia and mortality among older adults with COVID-19. To do so, we conducted a search of 7 databases for relevant full-text articles. A cohort study and case-control study were included. A meta-analysis was performed to synthesize the pooled odds ratio with a random-effects model. We identified studies that reported mortality among older adults with dementia and non-dementia who have COVID-19. The pooled mortality rates of dementia and non-dementia older adults infected with COVID-19 were 39% (95% CI: 0.23 – 0.54%, I 2 = 83.48%) and 20% (95% CI: 0.16 – 0.25%, I 2 = 83.48%), respectively. Overall, dementia was the main factor influencing poor health outcomes and high rates of mortality in older adults with COVID-19 infection (odds ratio 2.96; 95% CI 2.00 – 4.38, I 2 = 29.7%), respectively. Our results show that older adults with dementia with COVID-19 infection have a higher risk of mortality compared with older adults without dementia. This current study further highlights the need to provide focused care to the older adults with dementia or cognitive impairment who have COVID-19.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

Saragih

Saragih²,

Batubara

et al. 2021

Geriatric Nursing

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“…Emerging evidence has suggested that AD significantly increases the morbidity of COVID-19. A retrospective study in Spain has suggested cognitive impairment (29.1%) as one of the most frequent comorbidities in deceased COVID-19 patients [63]. Moreover, AD was the most common diagnosis for cognitive impairment in the confirmed COVID-19 group (9.3% of all patients) [63].…”

Section: Ad Patients Exhibit Elevated Morbidity and Mortality Of Covid-19mentioning

confidence: 99%

COVID-19 and Alzheimer’s disease: how one crisis worsens the other

Xia

Wang

Zheng

2021

Transl Neurodegener

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Alzheimer’s disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The morbidity and mortality of COVID-19 are elevated in AD due to multiple pathological changes in AD patients such as the excessive expression of viral receptor angiotensin converting enzyme 2 and pro-inflammatory molecules, various AD complications including diabetes, lifestyle alterations in AD, and drug-drug interactions. Meanwhile, COVID-19 has also been reported to cause various neurologic symptoms including cognitive impairment that may ultimately result in AD, probably through the invasion of SARS-CoV-2 into the central nervous system, COVID-19-induced inflammation, long-term hospitalization and delirium, and post-COVID-19 syndrome. In addition, the COVID-19 crisis also worsens behavioral symptoms in uninfected AD patients and poses new challenges for AD prevention. In this review, we first introduce the symptoms and pathogenesis of COVID-19 and AD. Next, we provide a comprehensive discussion on the aggravating effects of AD on COVID-19 and the underlying mechanisms from molecular to social levels. We also highlight the influence of COVID-19 on cognitive function, and propose possible routes of viral invasion into the brain and potential mechanisms underlying the COVID-19-induced cognitive impairment. Last, we summarize the negative impacts of COVID-19 pandemic on uninfected AD patients and dementia prevention.

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“…Severe COVID-19 affects elderly with chronic diseases, including cognitive decline, in high proportion compared to general adult population [2,3]. According to recent studies, dementia is a major risk factor for COVID-19 severity [4,5]. Concomitantly, the risk of exposure to the infection is more important in patients with dementia, highly exposed in the context of long-term care facilities, frequent hospitalizations and intellectual decline.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in Adults With Dementia: Clinical Features and Predictive Factors of Mortality. A Clinical Cohort Study on 125 Patients

Vrillon

Mhanna

Aveneau

et al. 2021

Preprint

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BACKGROUNDThere is limited evidence on the characteristics and outcome of patients with dementia hospitalized for novel coronavirus infection (COVID-19).METHODWe conducted a prospective study in 2 gerontologic Covid Units in Paris, France, from March 14th 2020 to May 7th 2020. Patients with dementia hospitalized for confirmed COVID-19 infection were systematically enrolled. A binary logistic regression analysis was performed to identify factors associated with mortality at 21 days.RESULTSWe included 125 patients. Median age was 86 (IQI 82-90); 59.4% were female. Most common causes of dementia were Alzheimer’s disease, mixed dementia and vascular dementia. 67.2% had ≥2 comorbidities; 40.2% lived in a long-term care facility. The most common symptoms at COVID-19 onset were confusion and delirium (82.4%), asthenia (76.8%) and fever (72.8%) before polypnea (51.2%) and desaturation (50.4%). Falls were frequent at the initial phase of the disease (35.2%). The fatality rate at 21 days was 22.4%. Chronic kidney disease and CRP at admission were independent factors of death. Persisting confusion, mood and behavioral disorders were observed in survivors (19.2%).CONCLUSIONCOVID-19 in demented individuals is associated with severe outcome in SARS-CoV-2 infection and is characterized by specific clinical features and complications, with confusion and delirium at the forefront. COVID‐19 testing should be considered in front of any significant change from baseline.

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Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

Cited by 36 publications

References 18 publications

Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

COVID-19 and Alzheimer’s disease: how one crisis worsens the other

COVID-19 in Adults With Dementia: Clinical Features and Predictive Factors of Mortality. A Clinical Cohort Study on 125 Patients

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