Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

Saragih, Ita Daryanti; Saragih, Ice Septriani; Batubara, Sakti Oktaria; Lin, Chia‐Ju

doi:10.1016/j.gerinurse.2021.03.007

Cited by 34 publications

(44 citation statements)

References 44 publications

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“…However, patients with Dementia are immunocompromised and may present with non-respiratory symptoms such as delirium or isolated functional decline. These situations may reduce early disease recognition and increase patients’ mortality ( Azarpazhooh et al, 2020 ; Saragih et al, 2021 ). In addition, the current review found that dyspnoea was associated with the mortality of older people with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis

Damayanthi

Prabani

Weerasekara

2021

Gerontology and Geriatric Medicine

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Background Whilst people of all ages are affected in some way by COVID-19 virus, older people are at a high mortality risk. This study aimed to systematically review the numerous factors associated with mortality among COVID-19 infected older people. Method PubMed and Science Direct were searched from inception to the April 15, 2021. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and Joanna Briggs Institute critical appraisal tool to assess the methodological quality of the included studies. Results Of the 4957 studies identified, 20 were included in the qualitative analysis, while 10 were included in the quantitative analysis. Male sex (OR = 2.22, 95% CI = 1.23–3.99), age (over 75 years old) (OR = 3.36, 95% CI = 2.30–4.90), Dementia (OR = 3.69, 95% CI = 1.99–6.83) and Dyspnoea (OR = 3.16, 95% CI = 2.61–3.82), were found to be significantly associated with mortality. There is no significant association between Diabetes, or Hypertension. Conclusion Older age, male gender, dyspnoea and dementia were associated with a greater risk of death of older people from COVID-19 infection. These findings may help health care professionals to identify high-risk groups, facilitate appropriate remedial measures, and control mortality among older people.

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Section: Discussionmentioning

confidence: 99%

Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis

Damayanthi

Prabani

Weerasekara

2021

Gerontology and Geriatric Medicine

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“…Dementia was found to be one of the strongest risk factors for COVID-19 and associated with a higher mortality [ 126 , 127 , 128 , 129 , 130 ]. Apparently, patients with dementia have difficulties in following hygiene rules, mask requirements, behavioral instructions and distancing rules due to cognitive deficits [ 124 , 131 ].…”

Section: Chaptermentioning

confidence: 99%

Can SARS-CoV-2 Infection Lead to Neurodegeneration and Parkinson’s Disease?

et al. 2021

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The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since 2020. Links between the newly discovered viral infection and the pathogenesis of neurodegenerative diseases have been investigated in different studies. This review aims to summarize the literature concerning COVID-19 and Parkinson’s disease (PD) to give an overview on the interface between viral infection and neurodegeneration with regard to this current topic. We will highlight SARS-CoV-2 neurotropism, neuropathology and the suspected pathophysiological links between the infection and neurodegeneration as well as the psychosocial impact of the pandemic on patients with PD. Some evidence discussed in this review suggests that the SARS-CoV-2 pandemic might be followed by a higher incidence of neurodegenerative diseases in the future. However, the data generated so far are not sufficient to confirm that COVID-19 can trigger or accelerate neurodegenerative diseases.

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“…From a health perspective, people with dementia have a high risk of contracting COVID-19 and, if infected, have a high risk of disease-related morbidity and mortality [3][4][5]. To protect those most vulnerable, governments put in place restrictions such as social distancing, isolation, and limitations on household mixing to help curb the spread of the virus [6,7].…”

Section: Introductionmentioning

confidence: 99%

A comparison of well-being of carers of people with dementia and their ability to manage before and during the COVID-19 pandemic: findings from the IDEAL study

Gamble

Parker

Quinn³

et al. 2022

Preprint

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Background Lockdown and social restriction measures imposed to curb the spread of COVID-19 in the United Kingdom impacted on carers of people with dementia, limiting their access to support services and increasing perceived burden of caring. Few studies have compared data collected during the pandemic and data collected before the pandemic to examine the effect of these changes. Objective To explore whether the COVID-19 pandemic affected the well-being of carers of people with dementia, and their ability to cope with their caring responsibilities. Methods Carers of people with dementia living in the community who were enrolled in the IDEAL programme were split into two groups matched on demographic characteristics: the ‘pre-pandemic group’ (n = 312), assessed at two time points prior to the pandemic, and the ‘pandemic group’, assessed prior to and several months into the pandemic (n = 156). Self-report measures of carer well-being, quality of life, coping, perceived competence and role captivity were completed. Results Compared to the pre-pandemic group, those in the pandemic group appeared to cope better and had more stable self-rated competency and role captivity. They did not differ in terms of well-being or quality of life. Conclusion Despite reports of negative impacts on carers early in the pandemic, our findings suggest the pandemic had little negative longer-term impact on carers of people with dementia, and in fact they appeared to have a more positive attitude towards coping several months into the pandemic.

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Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study

Cited by 34 publications

References 44 publications

Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis

Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis

Can SARS-CoV-2 Infection Lead to Neurodegeneration and Parkinson’s Disease?

A comparison of well-being of carers of people with dementia and their ability to manage before and during the COVID-19 pandemic: findings from the IDEAL study

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