Cognitive Decline Before and After Incident Coronary Events

Xie, Weixin; Zheng, Feihu; Li, Yan; Zhong, Bao‐Liang

doi:10.1016/j.jacc.2019.04.019

Cited by 133 publications

(115 citation statements)

References 36 publications

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“…Second, similar to other studies, 60,61 for logistical reasons, the diagnosis of CVD was self-reported. Medical records were not available in the CHARLS; however, some other large-scale studies, 28 such as the English Longitudinal Study of Aging, found that self-reported incident coronary heart disease had a good agreement with medical records (accuracy, 77.5%). Third, only participants from China were involved in this study; thus the findings may not fully generalize to other countries.…”

Section: Discussionmentioning

confidence: 99%

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Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Zheng

et al. 2019

JAMA Netw Open

126

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Key PointsQuestionAre depressive symptoms associated with incident cardiovascular disease among middle-aged and older Chinese adults?FindingsIn this cohort study of 12 417 Chinese adults, participants with depressive symptoms at baseline had higher incident rates of cardiovascular disease compared with those without such symptoms. Elevated depressive symptoms as a whole and 2 individual symptoms (restless sleep and loneliness) were significantly associated with increased risk of cardiovascular disease after adjusting for potential confounders.MeaningThis study suggests that depressive symptoms, particularly restless sleep and loneliness, may be associated with incident cardiovascular disease among middle-aged and older Chinese adults.

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Section: Discussionmentioning

confidence: 99%

“…The date of CVD diagnosis was recorded as being between the date of the last interview and that of the interview reporting an incident CVD. 28,29…”

Section: Methodsmentioning

confidence: 99%

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Zheng

et al. 2019

JAMA Netw Open

126

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“…This approach has been widely adopted to calculate z scores of global cognitive function. 30 , 31 , 32 , 33 , 34 …”

Section: Methodsmentioning

confidence: 99%

Association Between Sleep Duration and Cognitive Decline

et al. 2020

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“…Our results support the notion that CVD patients are not more likely than their non-CVD counterparts to experience global cognitive changes (that would clinically manifest as mild cognitive impairment or dementia) but do not speak to whether CVD patients have declines in cognitive performance in speci c domains. Multiple previous studies examining accelerated cognitive decline in CVD patients have examined isolated cognitive domains rather than global cognitive status, and these studies have observed that CVD patients have faster cognitive decline in certain domains, such as verbal memory, information processing speed, and temporal orientation, but not in others, such as executive function and semantic uency [17,18]. It is di cult to extrapolate whether these observed declines in speci c cognitive domains would translate into global cognitive impairment that manifests clinically.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have shown a connection between CVD and cognitive impairment [2][3][4][5][6][7][8], with multiple potential mechanisms at play, including atherosclerotic-related cerebrovascular disease (causing cerebral hypoxia, brain infarctions, and damage to the blood-brain barrier) [9][10][11]; oxidative stress and in ammatory immune responses [12,13]; and thromboembolism from concomitant atrial brillation [14,15]. More recently, several longitudinal studies have indicated that incident CVD is associated with an acceleration in the decline in memory and processing speed that occurs normally with age [16][17][18]. This research suggests that onset of CVD may serve as a cognitive 'in ection point,' whereby incident CVD leads to a more rapid deterioration in patients' cognition.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Disease and Cumulative Incidence of Cognitive Impairment in The Health and Retirement Study

Covello

Horwitz

Singhal

et al. 2020

Preprint

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Background: We sought to examine whether people with a diagnosis of cardiovascular disease (CVD) experienced a greater incidence of subsequent cognitive impairment (CI) compared to people without CVD, as suggested by prior studies, using a large longitudinal cohort. Methods: We employed Health and Retirement Study (HRS) data collected biennially from 1998-2014 in 1,305 U.S. adults age ≥65 newly diagnosed with CVD vs. 2,610 age- and gender-matched controls. Diagnosis of CVD was adjudicated with an established HRS methodology and included self-reported coronary heart disease, angina, heart failure, myocardial infarction, or other heart conditions. CI was defined as a score <11 on the 27-point modified Telephone Interview for Cognitive Status. We examined incidence of CI over an 8-year period using a cumulative incidence function accounting for the competing risk of death.Results: Mean age at study entry was 73 years, 55% were female, and 13% were non-white. Cognitive impairment developed in 1,029 participants over 8 years. The probability of death over the study period was greater in the CVD group (19.8% vs. 13.8%, p <.001). The cumulative incidence analysis, which adjusted for the competing risk of death, showed no significant difference in likelihood of cognitive impairment between the CVD and control groups (29.7% vs. 30.6%, p = 0.64). This finding did not change after adjusting for relevant demographic and clinical characteristics using a proportional subdistribution hazard regression model.Conclusions: Overall, we found no increased risk of subsequent CI among participants with CVD (compared with no CVD), despite previous studies indicating that incident CVD accelerates cognitive decline.

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Cognitive Decline Before and After Incident Coronary Events

Cited by 133 publications

References 36 publications

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Association Between Sleep Duration and Cognitive Decline

Cardiovascular Disease and Cumulative Incidence of Cognitive Impairment in The Health and Retirement Study

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