Association Between Sleep Duration and Cognitive Decline

Ma, Yanjun; Liang, Lirong; Zheng, Feihu; Shi, Le; Zhong, Bao‐Liang; Xie, Weixin

doi:10.1001/jamanetworkopen.2020.13573

Cited by 236 publications

(182 citation statements)

References 56 publications

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“…Second, analyses were carried out among participants with no cognitive impairmentsexcluding those at the bottom age-and sex-specific quintile of global cognition. Global cognition measures were derived using data on episodic memory, time orientation and executive function in line with a previous CHARLS and ELSA study 27 . Third, analyses were restricted to participants with episodic memory scores across all three waves.…”

Section: Statistical Analysesmentioning

confidence: 99%

Four-year trajectories of episodic memory decline in mid-late life by living arrangements: a cross-national comparison between China and England

Ruiz

Bobák

et al. 2021

J Epidemiol Community Health

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BackgroundThere is mixed evidence on the association between living arrangements and mid-late life cognition, which may be due to distinct familial arrangements and preferences between populations. To address such heterogeneity, we assessed these associations in China and England.MethodsFour-year trajectories of episodic memory scores (0–20, word recall test) by living arrangements (living with partner only, living with partner and children/grandchildren, living with no partner but with children/grandchildren, and living alone) were estimated using latent growth curve modelling for men and women aged 50+ from China (n=12 801) and England (n=10 964).ResultsAfter adjusting for baseline socioeconomic, health behaviours and health covariates, worse baseline memory was found in Chinese adults living with no partner but with children/grandchildren and in Chinese women living with partner and children/grandchildren, compared with those living with partner only. Better baseline memory was associated with living alone in English women. A faster memory decline was found in Chinese men living with no partner but with children/grandchildren (−0.122 word/year, 95% CI −0.213 to –0.031), as well as in English women living with children/grandchildren with (−0.114, 95% CI −0.180 to –0.049) or without (−0.118, 95% CI −0.209 to –0.026) a partner, and those living alone (−0.075, 95% CI −0.127 to –0.024). No differences at baseline nor over follow-up were found between English men in different living arrangements.ConclusionOverall, our findings did not confirm the protective effects of co-residence with children/grandchildren, nor the detrimental effects of living alone on mid-late life cognition in China and England.

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Section: Statistical Analysesmentioning

confidence: 99%

Four-year trajectories of episodic memory decline in mid-late life by living arrangements: a cross-national comparison between China and England

Ruiz

Bobák

et al. 2021

J Epidemiol Community Health

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“…Thus, measuring this symptom in daily clinical practice could provide a helpful, rapid, and easy tool for clinicians to identify those cases at risk of AD. Those subjects at risk should be kept under observation over time and offered effective dementia prevention strategies [ 2 , 6 , 37 , 63 , 64 ] in order to prevent progression to AD.…”

Section: Discussionmentioning

confidence: 99%

Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project

Vaquero-Puyuelo

De‐la‐Cámara

Olaya

et al. 2021

IJERPH

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(1) Introduction: Dementia is a major public health problem, and Alzheimer’s disease (AD) is the most frequent subtype. Clarifying the potential risk factors is necessary in order to improve dementia-prevention strategies and quality of life. Here, our purpose was to investigate the role of the absence of hedonic tone; anhedonia, understood as the reduction on previous enjoyable daily activities, which occasionally is underdetected and underdiagnosed; and the risk of developing AD in a cognitively unimpaired and non-depressed population sample. (2) Method: We used data from the Zaragoza Dementia and Depression (ZARADEMP) project, a longitudinal epidemiological study on dementia and depression. After excluding subjects with dementia, a sample of 2830 dwellers aged ≥65 years was followed for 4.5 years. The geriatric mental state examination was used to identify cases of anhedonia. AD was diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. A multivariate survival analysis and Cox proportional hazards regression model were performed, and the analysis was controlled by an analysis for the presence of clinically significant depression. (3) Results: We found a significant association between anhedonia cases and AD risk in the univariate analysis (hazard ratio (HR): 2.37; 95% CI: 1.04–5.40). This association persisted more strongly in the fully adjusted model. (4) Conclusions: Identifying cognitively intact individuals with anhedonia is a priority to implement preventive strategies that could delay the progression of cognitive and functional impairment in subjects at risk of AD.

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“…In the main analysis, the sleep duration value of those who sleep less than 4 h or long than 10 h was defined as “1”, and the sleep duration value of those who slept between 4 h and 10 h was defined as “0”. The selection of the cut-off point was based on a previous study, reporting at most 4 or at least 10 hours of sleep duration could accelerate the cognitive decline duration a follow-up of 4 years, among Chinese 6 . The optimal sleep duration for cognitive function of our study population was approximately 7 hours.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive function test is a key way to detect dementia. The impact of sleep duration on cognitive function was widely reported, by cross-sectional studies 4 , longitudinal studies 5,6 , and the mendelian randomization study 7 . Solid epidemiological evidence supports an unidirectional association that both short and long sleep durations are associated with lower cognitive function 6 .…”

Section: Introductionmentioning

confidence: 99%

“…The impact of sleep duration on cognitive function was widely reported, by cross-sectional studies 4 , longitudinal studies 5,6 , and the mendelian randomization study 7 . Solid epidemiological evidence supports an unidirectional association that both short and long sleep durations are associated with lower cognitive function 6 . Only a few studies learned the effects of cognitive function on sleep duration, reporting people with Alzheimer disease (AD) or mild cognitive impairment (MCI) had a higher prevalence of sleep disturbance 8-11 and different sleep architecture 12-14 .…”

Section: Introductionmentioning

confidence: 99%

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Bidirectional Associations between Short or Long Sleep Duration and Cognitive Function: the China Health and Retirement Longitudinal Study

Hua

Sun

Fang

2021

Preprint

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IMPORTANCEThe bidirectional association between sleep duration and cognitive function has not been conclusively demonstrated.OBJECTIVETo investigate the longitudinal association between sleep duration and cognitive function among middle-aged and elderly Chinese participants.Design, SETTING, AND PARTICIPANTSA national representative and prospective longitudinal study in China. 7984 participants aged 45 years and above were assessed at baseline between June 2011 and March 2012 (wave 1) and 2013 (wave 2), 2015 (wave 3) and 2018 (wave4).MAIN OUCOMES AND MEASURESSelf-reported nighttime sleep duration was evaluated by interview. Cognitive function was evaluated via assessments of global cognition, which reflected the ability of episodic memory, visuospatial construction, calculation, orientation and attention.ResultsRegarding the 7984 participants in wave 4, the mean (SD) age was 64.7 (8.4), 3862 (48.4) were male, and 6453 (80.7) lived in rural area. There were 14981, 11768 (78.6%), 10192 (68.0%), 7984 (53.3%) participants in the four waves of the study, respectively. Latent growth models showed both sleep duration and global cognition worsen over time. Cross-lagged models indicated that long or short sleep duration in the previous wave was associated lower global cognition in the next wave (standardized β=-0.066; 95%CI: −0.073, −0.059; P<0.001; Wave 1 to 2), and lower global cognition in the previous wave was associated with long or short sleep duration in the next wave (standardized β=-0.106; 95%CI: −0.116, −0.096; P<0.001; Wave 1 to 2). Global cognition was probably the major driver in this reciprocal associations.CONCLUSIONS AND REVELANCEThere were bidirectional associations between long or short sleep duration and cognitive function. Lower cognitive function had a stronger association with worse cognitive function than the reverse. A moderate sleep duration is always recommended. Moreover, attention should be paid on the declined cognition and cognitive therapy among older adults with short or long sleep duration.

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Association Between Sleep Duration and Cognitive Decline

Abstract: This pooled cohort study investigates the association between sleep duration and cognitive decline in a combined analysis of 2 nationally representative aging cohorts.

Cited by 236 publications

References 56 publications

Four-year trajectories of episodic memory decline in mid-late life by living arrangements: a cross-national comparison between China and England

Four-year trajectories of episodic memory decline in mid-late life by living arrangements: a cross-national comparison between China and England

Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project

Bidirectional Associations between Short or Long Sleep Duration and Cognitive Function: the China Health and Retirement Longitudinal Study

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