Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Li, Haibin; Zheng, Deqiang; Li, Zhiwei; Wu, Zhiyuan; Feng, Wei; Cao, Xue; Wang, Jiaxin; Gao, Qi; Li, Xia; Wang, Wei; Hall, Brian J.; Xiang, Yu Tao; Guo, Xiuhua

doi:10.1001/jamanetworkopen.2019.16591

Cited by 127 publications

(90 citation statements)

References 64 publications

(118 reference statements)

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“…Furthermore, our study is the one evaluating relationship of upper lip morphology and skeletal patterns with a much larger sample size compared with similar previous studies [ 2 , 7 , 25 , 26 ], which confirmed the reliability of our results. A large sample size allows us to conduct multivariate linear regression to fully adjust the covariates, which is a common statistical method used in real-world studies [ 41 , 42 , 43 ], thus increasing the accuracy and authenticity of our comparison and association analysis. Moreover, the subgroup analysis combining sagittal and vertical patterns provided a more thorough and in-depth map of relationship between upper lip characteristics and skeletal patterns, which may guide early intervention in specific skeletal patterns for improvement in lip morphology.…”

Section: Discussionmentioning

confidence: 99%

Association of Upper Lip Morphology Characteristics with Sagittal and Vertical Skeletal Patterns: A Cross Sectional Study

et al. 2021

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Background: Upper lip morphology is essential in diagnosis and treatment of orthodontics and orthognathic surgery. This study is aimed to evaluate the association between upper lip characteristics (ULCs) and skeletal patterns (SPs). Methods: 2079 patients were involved and grouped by sagittal and vertical. Class I, II, and III were identified by ANB angle, while normodivergent, hyperdivergent, and hypodivergent were identified by Facial Height Index and Sum of Angles. ULCs were evaluated by superior sulcus depth, nasolabial angle, upper lip length, basic upper lip thickness, and upper lip thickness. Confounders including demography, malocclusion, upper incisors, and upper lips were adjusted by multivariate linear regression to identify the association between ULCs and SPs. Group differences were evaluated with analysis of variance and Chi-square test. Results: The mean value of ULCs and prevalence of SPs were explored in the Western China population. ULCs were significantly different in various sagittal, vertical, and combined SPs. Superior sulcus depth was negatively related to Class II, and positively related to Class III and the hypodivergent pattern after adjusted by confounders. Conclusion: ULCs significantly varied among different SPs, while only superior sulcus depth was independently associated with SPs, indicating superior sulcus depth is the only ULC that might be significantly corrected by intervention of skeletal growth.

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Section: Discussionmentioning

confidence: 99%

Association of Upper Lip Morphology Characteristics with Sagittal and Vertical Skeletal Patterns: A Cross Sectional Study

et al. 2021

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“…cardiovascular disorders) and unnatural (e.g. suicide) causes [ 22 – 27 ]. Furthermore, within the MDD group, patients with TRD also have higher all-cause mortality (particularly mortality from external causes, such as accidents and suicides) than patients with non-TRD MDD [ 13 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis

et al. 2021

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Purpose Treatment-resistant depression (TRD) is associated with a poor quality of life and high economic burden. This observational retrospective epidemiological study aimed to estimate the proportion of patients with TRD within a cohort of patients with major depressive disorder (MDD) in Hungary and examine the mortality and comorbidities of patients with and without TRD. Patients and methods This study included patients with MDD who experienced onset of a new depressive episode between 01 January 2009 and 31 August 2015, using data from a nationwide, longitudinal database. Results Overall, 99,531 patients were included in the MDD cohort, of which 8,268 (8.3%) also met the criteria for TRD. The overall survival of non-TRD patients was longer than in TRD patients; the risk of mortality for TRD patients was significantly higher than of non-TRD patients (HR [CI] 1.381 [1.212–1.571]; p<0.001). Patients with TRD had a significantly higher probability of having “Neurotic, stress-related and somatoform disordersˮ, autoimmune conditions, cardio- or cerebrovascular diseases, thyroid gland diseases and self-harming behaviour not resulting in death than non-TRD patients (for all comparisons, p values were less than 0.005). Discussion To our best knowledge, this is the first study to assess the frequency of TRD in Hungary. In a cohort of Hungarian MDD patients, we have found that the proportion of TRD (~8.3%) is comparable to those reported in previous studies with similar methodology from other countries. The majority of our other main findings (e.g. more frequent self-harming behaviour, increased risk of “Neurotic, stress-related and somatoform disordersˮ and higher overall mortality in TRD subjects) are also in line with previous results from other countries. Taking the substantial proportion of patients with TRD into consideration, a more comprehensive and targeted treatment strategy would be required for these individuals.

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“…Our finding is in line with prior prospective study investigating the association of depressive symptoms with developing MetS among Iranian elderly population, especially in women 19 . The interaction between depression and hypertension is pathophysiologically reasonable 49 . A meta-analysis of prospective cohort found that patients with depressive and hypertension have increased sympathetic tone and increased secretion of adrenocorticotropic hormone and cortisol 50 .…”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms and 5-year incident metabolic syndrome among older adults

Hua

Ma³

et al. 2021

Sci Rep

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Little is known regarding the association between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. This study aimed to examine the association of depressive symptoms with MetS and its components among Chinese elderly. Based on whether they showed depressive symptoms at baseline, 262 age-gender-matched participants from a community-based cohort study were included. The presence of depressive symptoms was measured using the nine-item Patient Health Questionnaire (PHQ-9). MetS was defined according to the Adult Treatment Panel III of the National Cholesterol Education Program. Linear regression and logistic regression analyses were performed to assess associations of depressive symptoms with MetS and its components. The incidence of MetS among the participants with depressive symptoms at baseline was 15.27% (20/131). The association of the presence of depressive symptoms with MetS was significant (odds ratio [OR] = 2.53, 95% confidence intervals [CI] = 1.07, 5.95). There was a negative association between depressive symptoms and hypertension (OR = 0.04, 95% CI = 0.002, 0.98). The change in mean arterial pressure varies approximately 1.03 mmHg with a 1-point change in PHQ-9 score. In this study, baseline depressive symptoms were associated with subsequent MetS. The presence of depressive symptoms was negatively associated with elevated mean arterial pressure.

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Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults

Cited by 127 publications

References 64 publications

Association of Upper Lip Morphology Characteristics with Sagittal and Vertical Skeletal Patterns: A Cross Sectional Study

Association of Upper Lip Morphology Characteristics with Sagittal and Vertical Skeletal Patterns: A Cross Sectional Study

Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis

Depressive symptoms and 5-year incident metabolic syndrome among older adults

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