“…Among available studies, using no pharmacological treatments to alleviate these symptoms, cognitive behavior therapy (CBT) and physical exercise interventions are empirically validated. The benefits of CBT and exercise are supported by meta-analyses of findings from multiple clinical trials for depression (Cuijpers, Cristea, Karyotaki, Reijnders, & Huibers, 2016;Schuch et al, 2016), anxiety (Cuijpers et al, 2016;Stonerock, Hoffman, Smith, & Blumenthal, 2015), fatigue (Larun, Brurberg, Odgaard-Jensen, & Price, 2016;Price, Mitchell, Tidy, & Hunot, 2008), and pain (Geneen et al, 2017;Williams, Eccleston, & Morley, 2012). CBT was also found to effectively decrease these psychological symptoms in adults with multiple sclerosis (Akker et al, 2016), chronic fatigue syndrome (Malouff, Thorsteinsson, Rooke, Bhullar, & Schutte, 2008), cancer (Sheard & Maguire, 1999), fibromyalgia (Bernardy, Klose, Busch, Choy, & Häuser, 2013), and coronary heart disease (Hackett, Anderson, House, & Xia, 2008).…”