Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Sartini, Marina; Bragazzi, Nicola Luigi; Spagnolo, Anna Maria; Schinca, Elisa; Ottria, Gianluca; Dupont, Chiara; Cristina, Maria Luisa

doi:10.3390/nu11030694

Cited by 59 publications

(42 citation statements)

References 44 publications

(43 reference statements)

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“…Regarding ethnicity, a significant protective association was noted in European men and in Asian women. Decaffeinated coffee exhibited a protective effect in both men and women [ 53 ]. On the contrary, other researchers have found no protective evidence for coffee.…”

Section: Coffee and The Gastrointestinal Tract: Focus On The Mucosmentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a complex mixture of thousands of bioactive compounds, and some of them have numerous potential health-promoting properties that have been extensively studied in the cardiovascular and central nervous systems, with relatively much less attention given to other body systems, such as the gastrointestinal tract and its particular connection with the brain, known as the brain–gut axis. This narrative review provides an overview of the effect of coffee brew; its by-products; and its components on the gastrointestinal mucosa (mainly involved in permeability, secretion, and proliferation), the neural and non-neural components of the gut wall responsible for its motor function, and the brain–gut axis. Despite in vitro, in vivo, and epidemiological studies having shown that coffee may exert multiple effects on the digestive tract, including antioxidant, anti-inflammatory, and antiproliferative effects on the mucosa, and pro-motility effects on the external muscle layers, much is still surprisingly unknown. Further studies are needed to understand the mechanisms of action of certain health-promoting properties of coffee on the gastrointestinal tract and to transfer this knowledge to the industry to develop functional foods to improve the gastrointestinal and brain–gut axis health.

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Section: Coffee and The Gastrointestinal Tract: Focus On The Mucosmentioning

confidence: 99%

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

et al. 2020

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“…In colorectal adenoma, coffee drinking is borderline protective [ 123 , 124 , 125 ]. For pancreas cancer, there is no association between coffee exposure and cancer risk [ 77 , 78 , 126 , 127 , 128 , 129 ].…”

Section: Impact Of Coffee On Cancer Risk In Humansmentioning

confidence: 99%

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig

Cunha

2020

Nutrients

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The health implications of acrylamide in food are a matter of concern based on toxicological studies in rodents, which showed that doses of acrylamide more than 100 times higher than those estimated to result from dietary exposure in humans are carcinogenic; however, the cancer types reported in rodents are species-specific, and whether these results can be extrapolated to humans is still in question. In fact, human epidemiological studies revealed a general lack of association between dietary acrylamide exposure and the incidence of different cancer types. Even occupational exposure to acrylamide, resulting in acrylamide exposure nearly 10 times higher than dietary exposure, did not increase tumor occurrence. Furthermore, the consumption of coffee, which is a main contributor of dietary acrylamide exposure, actually decreases the overall incidence of cancer in humans and afford global health benefits, increasing both lifespan and healthspan on ageing. This paradox clearly illustrates the risk of evaluating an individual molecule independently of its complete food matrix, which may have other components that completely override the effects of the considered molecule.

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“…Both genetic and environmental factors play an important role in the etiology of this disease [10]. Large population studies with varying strength of evidence have found CRC-protective factors such as certain food groups (fruits and vegetables [11], fish [12]), specific foods (garlic [13] and coffee [14]) and dietary components (fiber, resistant starch, folate, vitamin B6, vitamin D, calcium and magnesium) [9,15]. In addition, physical activity (PA) [16] and certain drugs (aspirin, non-steroidal anti-inflammatory drugs [17] and hormonal replacement therapy (HRT) in postmenopause [18]) could decrease the CRC risk.…”

Section: Introductionmentioning

confidence: 99%

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Alegría-Lertxundi

Aguirre

Bujanda³

et al. 2020

Nutrients

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Epidemiologic studies have revealed inconsistent evidence of gene-diet interaction in relation to colorectal cancer (CRC). The aim of this study was to analyze them in a sample of cases and controls from the population-based bowel cancer screening program of the Osakidetza/Basque Health Service. This study analyzed dietetic, genetic, demographic, socioeconomic factors and lifestyles. In the present manuscript, the survey design, sampling, instruments, measurements and related quality management were presented. Moreover, we analyze differences between cases and controls in some data, especially those related to diet. The participants were 308 cases and 308 age- and sex-matched subjects as controls. Cases were more likely than controls to have overweight/obesity (67.5% vs. 58.1%, p < 0.05), a lower intake of vitamin B2 (0.86 ± 0.23 vs. 0.92 ± 0.23 mg/1000 kcal, p < 0.01) and calcium:phosphorus ratio (0.62 ± 0.12 vs. 0.65 ± 0.13, p < 0.01). A higher proportion of cases than controls did not meet the Nutritional Objectives for saturated fatty acids (85.7% vs. 67.5%, p < 0.001) or cholesterol (35.4% vs. 25.0%, p < 0.01). In conclusion, the present study provides valuable data for analyzing the complexity of gene-diet interaction in relation to CRC. The results presented here suggest that overweight/obesity and a high intake of certain dietary components, especially saturated fatty acids and cholesterol, are more frequent in cases than in controls.

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Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies

Cited by 59 publications

References 44 publications

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

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