Coexpression of vascular endothelial growth factor and p53 protein in squamous cell carcinoma of the esophagus

Koide, Naoki; Nishio, Akira; Hiraguri, Manabu; Hanazaki, Kazuhiro; Adachi, Wataru; Amano, Jun

doi:10.1111/j.1572-0241.2001.03866.x

Cited by 38 publications

(42 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the correlation of VEGF and p53 protein expressions has been experimentally suggested, few studies demonstrate this correlation in patients with SCC of the esophagus. 10,36 In conclusion, our study did not find an association between p53 protein and VEGF expressions and worse long-term survival times. However, the search for other prognostic factors to identify patients at a greater risk of recurrence, who may benefit from neoadjuvant or adjuvant treatments, should go on.…”

Section: Discussionmentioning

confidence: 48%

See 1 more Smart Citation

Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus

Rosa

Schirmer

Gurski

et al. 2003

Diseases of the Esophagus

View full text Add to dashboard Cite

The most common genetic alterations found in a wide variety of cancers are p53 tumor suppressor gene mutations. p53 appears to be a nuclear transcription factor that plays a role in the control of cell proliferation, apoptosis, and the maintenance of genetic stability. Angiogenesis is a critical process in solid tumor growth and metastasis. Vascular endothelial growth factor (VEGF), a recently identified growth factor with significant angiogenic properties, may be a major tumor angiogenesis regulator. Few studies have investigated the association between p53 and VEGF expressions and prognosis in esophageal carcinoma. Forty-seven specimens resected from patients with stage II and III squamous cell carcinoma (SCC) of the esophagus were studied using immunohistochemical staining. VEGF and p53 expressions were observed in 40% and 53% of the tumors, respectively. The p53 and VEGF staining statuses were coincident in only 21% of the tumors, and no significant correlation was found between p53 and VEGF statuses. No clinicopathologic factors were significantly correlated with p53 or VEGF expression. No significant association between p53 and VEGF expressions and poor prognosis was found. In conclusion, p53 and VEGF were not correlated with prognosis in patients with stage II and III SCC of the esophagus.

show abstract

Section: Discussionmentioning

confidence: 48%

“…Few studies about the association between VEGF expression, angiogenesis and prognosis have been done in esophageal carcinoma. [7][8][9][10][11][12] At the same time, the p53 tumor suppressor gene has been found in a wide variety of cancers. Mutations in this gene are the most common genetic alterations found in malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus

Rosa

Schirmer

Gurski

et al. 2003

Diseases of the Esophagus

View full text Add to dashboard Cite

show abstract

“…Many trials attempting to predict metastasis with various biological markers have been performed but without success. 1,4,[9][10][11][12][13][14][15][16][17][18][19] Thus the investigation of p53 and other similar proteins in esophageal SCC may assist in management planning. 1,7,10,21 p53 may play an important role in growth and differentiation of fetal esophageal epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…The angiogenetic effect of p53 is also noted in colorectal and bladder cancers. 16 In the past, multiple research has shown that expression of p53 correlated well with the depth of tumor invasion, lymphatic invasion and lymph node metastasis. The rate of p53 expression was reported at 40-90% of esophageal carcinomas in the literature.…”

Section: Discussionmentioning

confidence: 99%

Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?

Han¹,

Can²,

Han

et al. 2007

Diseases of the Esophagus

View full text Add to dashboard Cite

The prognosis of esophageal squamous cell carcinoma is primarily determined by staging. Although radiological methods have revealed lymph node metastasis preoperatively, these radiological findings cannot be correlated with pathological staging. The aim of this study was to compare the expressions of p53, vascular endothelial growth factor C (VEGF C) and p21 with lymph node metastasis in preoperative endoscopic biopsy and postoperative resection material. Tissue samples were taken from 40 patients who had undergone endoscopic biopsies and radical esophagectomies. The expressions of p53, VEGF C and p21 proteins in these sections were immunohistochemically examined. The expression of each antibody was characterized as a negative or positive reaction according to the pattern and intensity of semiquantitative immunostaining. The staining pattern of antibodies was divided into three groups: < 10% cancer cells were accepted to be (-), 10-50% were (+), heterogenous and > 50% were (+ +), homogenous. For each antibody, statistical correlation with conventional prognostic parameters such as localization, microscopic grade, stage, pathological lymph node metastasis and survival, were investigated. p53 expression was observed in 65.5% (19/29) of lymph node positive cases, whereas p53 was in 50% (20/40) of cases. VEGF C was in 65% (26/40) and p21 was in 15% (6/40) of cases. p53 has the specificity of 90.9% and sensitivity rate of 65.5% in detecting lymph node metastasis and positive predictive value was 95%. Expression of p53 was significantly correlated with stage and lymph node metastasis (P = 0.02 and P = 0.03, respectively). Prediction of lymph node metastasis by p53 was correlated independently and in coexpression with VEGF C (P < 0.01). There was no relation detected between p21 and other parameters. In esophageal squamous cell carcinoma (SCC), p53 and VEGF C expressions were correlated with pathologically positive lymph nodes. When preoperative staging has been insufficient in esophageal carcinoma cases, immunohistochemical analysis of p53 and VEGF C staining in tissues could be an aid to clinicians regarding lymph node metastasis.

show abstract

“…The prognostic signi®cance of Ki-67 has been reported in salivary gland carcinomas (23±25), gastric carcinomas (43), renal cell carcinoma (44), breast cancer (45), esophageal squamous cell carcinoma (46), laryngeal carcinoma (47), and oral squamous cell carcinoma (48). However, other reports have shown that p53 or Ki-67 expression has no in¯uence on clinical outcome (49,50).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice

Kimi¹,

Ohki²,

Kumamoto³

et al. 2003

J Oral Pathology Medicine

View full text Add to dashboard Cite

Coexpression of vascular endothelial growth factor and p53 protein in squamous cell carcinoma of the esophagus

Abstract: These results suggest that mutant p53 expression is associated with angiogenesis and distant metastasis in esophageal SCC, and that the coexpression of p53 and VEGF may play an important role in angiogenesis, and have important clinical significance.

Cited by 38 publications

References 24 publications

Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus

Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus

Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?

Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice

Contact Info

Product

Resources

About