Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?

Han, Ünsal; Can, Özge; Han, Serdar; Kayhan, Burçak; Önal, Binnur

doi:10.1111/j.1442-2050.2007.00634.x

Cited by 25 publications

(27 citation statements)

References 22 publications

(82 reference statements)

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“…Cell proliferation markers have been classified in three categories: [1] growth fraction markers; [2] markers of specific cell cycle phases; and [3] cell cycle time markers. Growth fraction that is the ratio of cells growing within the cycle can be easily identified by Ki-67 or MIB-1 antibodies, identifying antigen expression on phases G1, S, G2 and M of the cell cycle 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Motta¹,

Zettler²,

Cambruzzi³

et al. 2009

Braz. j. otorhinolaryngol. (Impr.)

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Epi dermoid carcinomas represent from 90% to 95% of oral cavity malignant neoplasias, making up 13,470 cases/ year. Aims: To correlate p53 and Ki-67 expressions in mouth and tongue carcinomas with lymph node status, gender, histological grade, tumor volume and pathological stage. Materials and Methods:We carried out a retrospective study of 28 cases of mouth and tongue epidermoid carcinomas. They were submitted to immunohistochemical study in order to check the expression of p53 and Ki-67 antibodies and statistically compare them in terms of lymph node status, gender, histological grade, tumor volume and pathological staging. Results: The individually analyzed p53 proved to have statistical significance (p<0.05) when compared to tumor volume (p=0.029). Despite a strong tendency, the p53/tumor volume relation was not significant. When p53 + Ki67 were analyzed, tumor volume had p < 0.05 (p = 0.029). Discussion: Literature shows that the expression of p53 and Ki-67 is related to the presence of metastasis to lymph nodes and a worse prognosis. Conclusion: In oral cavity and tongue epidermoid carcinomas, p53 and Ki-67 are related to larger tumors, metastasis to lymph nodes and very likely to a worse prognosis.

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Section: Introductionmentioning

confidence: 99%

Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Motta¹,

Zettler²,

Cambruzzi³

et al. 2009

Braz. j. otorhinolaryngol. (Impr.)

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“…Furthermore, several biological markers predicting lymph node metastasis of ESCC have been identified. For example, Han et al (23) demonstrated that p53 and vascular endothelial growth factor C (VEGF C) expressions were correlated with lymph node metastasis in patients with ESCC and suggested that immunohistochemical analysis of these molecules could be useful for determining preoperative lymph node metastasis. The present study demonstrated that the rate of lymph node metastasis in patients with p12 CDK2-AP1 negative-T1sm ESCC was significantly higher than that of patients with p12 CDK2-AP1 positive specimens.…”

Section: Discussionmentioning

confidence: 99%

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

Hiyoshi

Watanabe²,

Hirashima³

et al. 2009

Oncol Rep

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Abstract. p12 CDK2-associating protein 1 (p12 CDK2-AP1 ) is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. In addition, p12CDK2-AP1 has also been shown to interfere in DNA replication. A reduction of p12 CDK2-AP1 expression is known to be a negative prognostic indicator in patients with oral squamous cell carcinoma. To elucidate the role of p12 CDK2-AP1 expression in esophageal squamous cell carcinoma (ESCC), we immunohistochemically examined the expression of p12 CDK2-AP1 protein in 120 resected ESCC specimens and determined its association with the clinicopathological characteristics and prognosis. Of the 120 ESCCs, 79 (65.8%) showed positive staining (≥25% of cancer cells showing p12 CDK2-AP1 expression), while 41 (34.2%) lacked the staining (<25% of cancer cells showing p12 CDK2-AP1 expression). Negative staining for p12 CDK2-AP1 was found to be significantly associated with advanced lesions [depth of tumor (P=0.001), lymph node metastasis (P<0.001), pathological stage (P<0.0001) and venous invasion (P<0.0001)], and a poor prognosis (disease-free survival and overall survival: log-rank P<0.05). The rate of lymph node metastasis in patients with p12 CDK2-AP1 negative-T1 ESCC was significantly higher than that in patients with p12 CDK2-AP1 positive one (P<0.05). These results suggest the downregulation of p12 CDK2-AP1 to be related to tumor aggressiveness and a poor prognosis in patients with ESCC.

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“…The TP53 gene is commonly mutated in human tumors (21,22); however, associations between mutant p53 expression and patient prognosis remain unclear. TP53 mutations often lead to a loss of tumor suppressor activity and an extended half-life; therefore, the accumulation of mutant p53 protein is detectable by immunohistochemistry (23). Previous studies have demonstrated that p53 expression correlates with tumor stage, lymph node metastasis and overall survival in EC (2,(23)(24).…”

Section: A B C Dmentioning

confidence: 99%

“…TP53 mutations often lead to a loss of tumor suppressor activity and an extended half-life; therefore, the accumulation of mutant p53 protein is detectable by immunohistochemistry (23). Previous studies have demonstrated that p53 expression correlates with tumor stage, lymph node metastasis and overall survival in EC (2,(23)(24). Consistent with these studies, p53 overexpression was found to be more frequent in lymph node-positive ESCCs in the current study.…”

Section: A B C Dmentioning

confidence: 99%

High p53 and MAP1 light chain 3A co-expression predicts poor prognosis in patients with esophageal squamous cell carcinoma

Wang

Xian-zhong

Chen

et al. 2013

Molecular Medicine Reports

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Abstract. p53 and microtubule-associated protein 1 light chain 3A (LC3A) are regulators of apoptosis and autophagy and are expressed at high levels in a number of human tumors. The purpose of the current study was to evaluate the clinicopathological and prognostic significance of p53 and LC3A expression levels in esophageal squamous cell carcinomas (ESCCs). p53 and LC3A expression levels were measured by immunohistochemistry in 114 patients with stage II/III (T any N+M 0 or T 3,4 N any M 0 ) ESCCs treated with surgery followed by adjuvant concurrent chemoradiotherapy. The overexpression of p53 and LC3A was observed in 57 and 54% of ESCC samples, respectively. p53 staining was nuclear and LC3A was localized to the cytoplasm of tumor cells. p53 overexpression was more frequently observed in ESCCs with positive lymph nodes (P=0.017). Patients with ESCCs overexpressing p53 and LC3A were associated with a lower 5-year overall survival rate than those with low p53 and LC3A expression (18.0 vs. 54.4%; P=0.001). Univariate and multivariate analyses revealed that the overexpression of p53 or LC3A was not associated with poor patient outcome (P>0.05). However, patients with high levels of p53 and LC3A co-expression had poor clinical prognoses (P=0.027). Thus, p53 and LC3A co-expression is an independent prognostic marker for patients with ESCC. IntroductionEsophageal carcinoma (EC) is a public health issue in China (1). It has a poor overall prognosis and treatment outcomes for patients with EC have not improved over the last few decades. Significant prognostic indicators include the extent of invasion and lymph node and distal metastases (2). However, specific patients with the same stage have different prognosis (3). Therefore, molecular markers to improve the outcome prediction for patients with EC must be identified.Classified as type I programed cell death, apoptosis is involved in a number of cancer-related processes, including tumorigenesis, tumor progression and cellular responses to chemotherapy and radiotherapy (4-6). The well-studied tumor suppressor protein, p53, is key to apoptosis and cancer development. Wild-type p53 inhibits tumor growth by inducing apoptosis and inhibiting angiogenesis and metastasis; however, the TP53 gene undergoes inactivating mutations in a variety of cancer types. More recently, p53 has been demonstrated to repress autophagy (7), indicating that apoptosis and autophagy may interact. Type II programmed cell death, or autophagy, is an evolutionarily conserved eukaryotic process important for maintaining homeostasis by recycling stable proteins and long-lived organelles (8).Autophagy is important in a number of physiological processes, including adaptation to hypoxia, prevention of tumorigenesis and antigen presentation (9-11). Although the role of autophagy in cancer is unclear, the current view is that it functions as a cytoprotective mechanism during tumor progression (12).Previously, microtubule-associated protein 1 light chain 3A (LC3A), one of three microtubule-associated protein ...

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Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?

Cited by 25 publications

References 22 publications

Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

Ki-67 and p53 correlation prognostic value in squamous cell carcinomas of the oral cavity and tongue

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

High p53 and MAP1 light chain 3A co-expression predicts poor prognosis in patients with esophageal squamous cell carcinoma

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