Immunohistochemical and genetic analysis of mandibular cysts in heterozygous <i>ptc</i> knockout mice

Kimi, Kenji; Ohki, Kohji; Kumamoto, Hiroyuki; Kondo, Mari; Taniguchi, Yoshihiro; Tanigami, Akira; Ooya, Kiyoshi

doi:10.1034/j.1600-0714.2003.00145.x

Cited by 31 publications

(40 citation statements)

References 28 publications

(49 reference statements)

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“…A similar variability in findings between different studies is also observed for the association of VEGF-A expression with clinical stage or nodal status. Some reports (Salven et al, 1997;Maeda et al, 1998;Neuchrist et al, 1999;Do et al, 2004), including our study, show no correlation between VEGF-A protein levels and these clinicopathological parameters, whereas others reported a relationship (Eisma et al, 1999;Mineta et al, 2000;Tae et al, 2000;Lim et al, 2003). These conflicting results highlight the necessity to perform retrospective studies using reliable methodology (preferentially quantitative) and a large cohort of patients.…”

Section: Discussionmentioning

confidence: 43%

“…Furthermore, VEGF-A has been described as an important prognostic factor in many types of human cancers (Dvorak, 2002). Several retrospective studies in HNSCC have demonstrated that VEGF-A expression is associated with clinicopathological factors and/or poor patient's outcome, suggesting that VEGF-A could serve as a prognostic marker (Eisma et al, 1997;Maeda et al, 1998;Mineta et al, 2000;Smith et al, 2000;Lim et al, 2003;Kimura et al, 2004;Uehara et al, 2004;Kyzas et al, 2005b). However, the status of VEGF-A remains unclear since other HNSCC retrospective studies have shown no correlation between VEGF-A expression and tumour prognosis (Salven et al, 1997;Tae et al, 2000;Do et al, 2004;Schimming et al, 2004).…”

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confidence: 99%

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Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Onesto

Chamorey

et al. 2006

Br J Cancer

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Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VEGF-A expression in HNSCCs and analysed whether its expression was associated with PAIP2 protein levels, a VEGF-A mRNA-binding partner that strongly regulates VEGF-A expression in tissue culture. We determined the correlation of VEGF-A and PAIP2 protein levels, quantitatively evaluated in tumour tissue homogenates from 54 patients with HNSCC, to clinicopathological parameters. We showed that VEGF-A expression in HNSCC is correlated to the stage of tumour differentiation ( P =0.050) and is an independent prognostic factor for progression-free survival ( P =0.001) and overall survival ( P =0.0004). In a pharynx carcinoma cell line, we demonstrated by RNA interference that VEGF-A expression is closely controlled by PAIP2. Moreover, in human HNSCCs, VEGF-A expression is significantly correlated to PAIP2 protein levels ( P =0.0018). Nevertheless, PAIP2 expression is associated with neither clinicopathological factors nor patient's survival. Our data suggest that, in contrast to PAIP2 protein levels, which are unrelated to tumour prognosis, VEGF-A expression could serve as a prognostic marker in head and neck cancer and may be helpful for targeted therapies.

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Section: Discussionmentioning

confidence: 43%

mentioning

confidence: 99%

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Onesto

Chamorey

et al. 2006

Br J Cancer

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“…4 El factor de crecimiento endotelial vascular muestra una asociación con la expresión del p53 y tiene valor pronósti-co en los carcinomas de glándulas salivares. 5 El papel de la radioterapia mejorando el control local y regional es constatado por Terhaard en un importante estudio en 538 pacientes. 6 Aunque parezca sorprendente, es difícil conocer la incidencia real de cáncer en España.…”

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“…La base de datos GLOBOCAN 4 The vascular endothelial growth factor shows an association with the expression of p53 and it has prognostic value in salivary gland carcinoma. 5 The role of radiotherapy for improving local and regional control is confirmed by Terhaard in an important study 6 en el año 2002; considerando que los tumores de glándulas salivares suponen un 3%, la incidencia anual de estas neoplasias sería de 345 casos (sería un cálculo indirecto y aproximado, ya que no hace estimación directa sobre glándulas salivares).…”

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Factores pronósticos en neoplasias malignas primarias de glándulas salivares: Estudio retrospectivo de 20 años

Cuéllar

2005

Rev Esp Cirug Oral y Maxilofac

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“…VEGF, in fact, is associated with several factors, such as the age of the patient, the dimensions of the tumour, the presence of lymphonodal metastasis, perineural invasion, vascular invasion, recurrence and survival (16). Recent studies (17) have shown how VEGF is involved in the proliferation of solid tumours, not only as a potent chemo-attractor for the preosteoclasts (18), but also as a molecule able to stimulate osteoclastic differentiation, as well as having a direct effect on the already differentiated osteoclasts (19).…”

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Immunohistochemical Evaluation of VEGF Inflamed Cystic Radicular Lesions and in Keratocysts

et al. 2005

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Vascular Endothelial Growth Factor, also known as Vascular Permeability Factor, is a multifunctional cytokine hyperexpressed during angiogenesis and in numerous physiological and pathological processes characterised by an increase of vascular permeability. The aim of this study was to evaluate the angiogenetic processes which are accompanied by an expansion of cystic radicular lesions and of keratocysts of the jaw bone. 12 subjects were chosen with an average age of 43 years, of whom 8 were males and 4 females. After an accurate history and physical examination, the patients underwent surgery for removal of the cysts. The samples taken were histologically and immunohistochemical examined. The histological exam confirmed the diagnosis of radicular cysts and keratocysts. The immunohistochemical examinations were positive for VEGF in all the lesions analysed, even though they had different immunostaining. Using a semi-quantitative method, in the radicular cyst samples it was possible to highlight a wider expression of the vascular component, both in the inflamed area and the adjacent stroma. The lesions with keratin content showed newly formed and modest vascularisation both in the area showing slight inflammation, where the cellular component was prevalent, and in the adjacent areas showing no inflammation. Therefore, angiogenesis could take on a primary role in the development of cystic lesions of the jaw. However, the differences of expression of the VEGF protein suggest the need for wider monitoring to better evaluate a possible use of such a protein as a diagnostic marker.

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Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice

Cited by 31 publications

References 28 publications

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance

Factores pronósticos en neoplasias malignas primarias de glándulas salivares: Estudio retrospectivo de 20 años

Immunohistochemical Evaluation of VEGF Inflamed Cystic Radicular Lesions and in Keratocysts

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