Coexistence of disseminated primary anetoderma and generalized granuloma annulare‐like papules

Ishida, Yuya; Naitoh, Motoko; Yoneyama, Kei; Shinkai, Hiroshi

doi:10.1111/j.1346-8138.2007.00271.x

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Secondary anetoderma is a rare event associated with numerous causes including neoplasias, inflammations, infections, and even drug use. 5–10 According to the literature, anetoderma secondary to syphilis may present in all phases of the infection, being more common in the secondary stage. 4 Although syphilis-associated lesions were the main cause of secondary anetoderma, they are now reported more commonly in patients with reactive serology for HIV.…”

Section: Discussionmentioning

confidence: 99%

“…The macrophage action in phagocytosis and destruction of the elastic fibers has already been confirmed through electron microscopy examinations as an important factor in anetoderma pathophysiology. 7,8 The demonstration of fragmented elastic fibers present within macrophages implicates that granulomatous diseases could evolve with anetoderma. 8–10 The first case here presented relates to this hypothesis with the granulomas at the syphilitic lesion and progression to anetoderma.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The demonstration of fragmented elastic fibers present within macrophages implicates that granulomatous diseases could evolve with anetoderma. 8–10 The first case here presented relates to this hypothesis with the granulomas at the syphilitic lesion and progression to anetoderma. Unfortunately, there was no histological analysis of the second case to evaluate possible coincidences of the manifestations that would support this line of reasoning.…”

Section: Discussionmentioning

confidence: 99%

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Anetoderma due to secondary syphilis: Report of two cases and discussion of the histopathological findings

et al. 2017

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Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature, the pathogenesis is still poorly determined. Anetoderma in syphilis is rare, and occurs even in the most uncommon cutaneous manifestations of the disease, such as the nodular form. In order to better understand the changes that lead to elastolysis, we propose a better correlation with the histopathological findings of the lesions that precede it. We present two cases of anetoderma secondary to syphilis, whose clinical aspects resembled the pattern of their initial secondary syphilis rash.

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