This study allows to validate RCM as a non-invasive method capable of monitoring actinic keratosis therapeutic response to 5-fluorouracil, presenting efficacy comparable to histological examination. Additionally, the results suggest that 5-fluorouracil may be a satisfactory option for therapeutic control of this condition.
Syphilis is a sexually transmitted disease caused by Treponema pallidum and
divided into three stages according to the duration of the disease: primary,
secondary and tertiary. Secondary syphilis has diverse clinical presentations,
such as papular-nodular lesions. This presentation is rare, with 15 cases
reported in the literature over the past 20 years. We report a case of secondary
syphilis with papular-nodular lesions in a healthy 63-year-old patient, who has
presented treponema in immunohistochemical examination of the skin lesions.
Genital warts can be diagnosed through physical examination and confirmed by
histopathology. Noninvasive methods are useful for ruling out other diagnoses with no
harm to the patient. In this study the clinical findings were compared to dermoscopy,
reflectance confocal microscopy (RCM), and to histopathology findings, in order to
determine possible patterns that can aid diagnosis of the lesion. It was possible to
identify structural changes on reflectance confocal microscopy that are already known
by dermoscopy, in addition to cellular changes previously seen only by
histopathological examination. This study shows the use of reflectance confocal
microscopy in cases of genital warts, providing important information that can be
used in further studies.
Subcutaneous fat necrosis of the newborn is a rare benign panniculitis found in
term and post-term neonates. Diagnosis is based on clinical characteristics and
specific alterations in the adipocytes, detected by anatomical pathology.
Subcutaneous fat necrosis of the newborn can occur in uncomplicated pregnancy
and childbirth. However, perinatal complications such as asphyxia, hypothermia,
seizures, preeclampsia, meconium aspiration, and even whole-body cooling used in
newborns with perinatal hypoxia/anoxia may be associated with this entity.
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