Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Abdeen, Ahmed; Abdelkader, Afaf; Elgazzar, Dina; Aboubakr, Mohamed; Abdulah, Omnia A.; Shoghy, Khaled; Abdel-Daim, Mohamed M.; El‐Serehy, Hamed A.; Najda, Agnieszka; El‐Mleeh, Amany

doi:10.1016/j.biopha.2020.110627

Cited by 32 publications

(29 citation statements)

References 55 publications

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“…In consistence with our previous studies, lipid peroxidation and loss of the cell membrane integrity are the main causes participating in the leakage of liver transaminases into the blood stream leading to elevation of their levels in the serum [ 34 , 39 , 41 , 42 , 43 ]. Moreover, the observed loss of the renal brush border in the histopathological examination might be attributed to the DLM-induced lipid peroxidation; where, the DLM-generated ROS disrupts the lipid content of the apical membrane [ 39 , 44 ]. Consequently, progressive accumulation of sloughed epithelia in the tubular lumen might explain the dilated tubules in the DLM-injured group [ 43 ].…”

Section: Discussionsupporting

confidence: 78%

“…ROS mediate the toxic impact of pyrethroid insecticides [ 35 ], and oxidative stress is the primary cause of liver harm [ 36 , 37 ]. MDA is a well-known by-product of lipid peroxidation and has been used as an oxidative stress marker [ 38 , 39 ]. Accumulative evidence suggested that a large amount of hydroxyl radical (OH • ) are produced during oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulative evidence suggested that a large amount of hydroxyl radical (OH • ) are produced during oxidative stress. OH • is the most injurious radical compared to other ROS that has a great affinity to the lipid content of the cell membrane [ 34 , 39 , 40 , 41 , 42 , 43 ]. Therefore, it is strongly suggested that the increased MDA levels was associated with DLM-induced ROS production.…”

Section: Discussionmentioning

confidence: 99%

“…Khalaf and his group found that the insecticide increased the expression of the caspase3 [ 50 ], confirming our obtained data. Our previous studies with others have linked mitochondrial dysfunction to apoptosis through the development of ROS and the activation of caspases [ 24 , 34 , 39 , 40 , 41 , 51 ]. Interestingly, in the present investigation, treatment with the antioxidant NAC reversed DLM-induced apoptotic responses in hepatic and renal tissue, revealing the antiapoptotic competence of NAC against DLM-induced tissue injury.…”

Section: Discussionmentioning

confidence: 99%

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N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues

Allam

Abdeen

Devkota

et al. 2022

IJERPH

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Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It is commonly used in agriculture and veterinary medicine. Humans and animals are exposed to DLM through the ingestion of polluted food and water, resulting in severe health issues. N-acetylcysteine (NAC) is a prodrug of L-cysteine, the precursor to glutathione. It can restore the oxidant-antioxidant balance. Therefore, this research aimed to examine whether NAC may protect broiler chickens against oxidative stress, at the level of biochemical and molecular alterations caused by DLM intoxication. The indicators of liver and kidney injury in the serum of DLM-intoxicated and NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, and apoptotic gene expressions (caspase-3 and Bcl-2) were investigated. All parameters were significantly altered in the DLM-intoxicated group, suggesting that DLM could induce oxidative damage and apoptosis in hepato-renal tissue. The majority of the changes in the studied parameters were reversed when NAC therapy was used. In conclusion, by virtue of its antioxidant and antiapoptotic properties, NAC enabled the provision of significant protection effects against DLM-induced hepato-renal injury.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues

Allam

Abdeen

Devkota

et al. 2022

IJERPH

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“…Increasing evidence suggests that CPF promotes apoptosis via producing ROS, which alters mitochondrial membrane potency, resulting in the liberation of the cytochrome c into the cytosol, triggering the cleaved caspase 3; thereby, the apoptotic cascade is initiated [ 41 ]. In consistence, the present study showed cellular apoptosis observed by an upregulated expression of activated caspase 3 protein after CPF-intoxication in the cortical tissue.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy

et al. 2021

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CPF (chlorpyrifos) is an organophosphate pesticide used in agricultural and veterinary applications. Our experiment aimed to explore the effects of thymoquinone (TQ) and/or lycopene (LP) against CPF-induced neurotoxicity. Wistar rats were categorized into seven groups: first group served as a control (corn oil only); second group, TQ (10 mg/kg); third group, LP (10 mg/kg); fourth group, CPF (10 mg/kg) and deemed as CPF toxic control; fifth group, TQ + CPF; sixth group, (LP + CPF); and seventh group, (TQ + LP + CPF). CPF intoxication inhibited acetylcholinesterase (AchE), decreased glutathione (GSH) content, and increased levels of malondialdehyde (MDA), an oxidative stress biomarker. Furthermore, CPF impaired the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) along with enhancement of the level of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β. CPF evoked apoptosis in brain tissue. TQ or LP treatment of CPF-intoxicated rats greatly improved AchE activity, oxidative state, inflammatory responses, and cell death. Co-administration of TQ and LP showed better restoration than their sole treatment. In conclusion, TQ or LP supplementation may alleviate CPF-induced neuronal injury, most likely due to TQ or LPs’ antioxidant, anti-inflammatory, and anti-apoptotic effects.

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Prevalence and outcomes of upper gastrointestinal bleeding in COVID‐19: A systematic review and meta‐analysis

Rathore,

Wint,

Goyal

et al. 2024

Reviews in Medical Virology

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Upper gastrointestinal bleeding (UGIB) in COVID‐19 presents challenges in patient management. Existing studies lack comprehensive review due to varied designs, samples, and demographics. A meta‐analysis can provide valuable insights into the incidence, features, and outcomes of UGIB in COVID‐19. A comprehensive literature search was carried out using several databases. We considered all appropriate observational studies from all over the world. Mantel‐Haenszel odds ratios and associated 95% confidence intervals (CIs) were produced to report the overall effect size using random effect models. Besides, Random effects models were used to calculate the overall pooled prevalence. Funnel plots, Egger regression tests, and Begg‐Mazumdar's rank correlation test were used to appraise publication bias. Data from 21 articles consisting of 26,933 COVID‐19 patients were considered. The pooled estimate of UGIB prevalence in patients admitted with COVID‐19 across studies was 2.10% (95% CI, 1.23–3.13). Similarly, the overall pooled estimate for severity, mortality, and rebleeding in COVID‐19 patients with UGIB was 55% (95% CI, 37.01–72.68), 29% (95% CI, 19.26–40.20) and 12.7% (95% CI, 7.88–18.42) respectively. Further, UGIB in COVID‐19 patients was associated with increased odds of severity (OR = 3.52, 95% CI 1.80–6.88, P = 0.001) and mortality (OR = 2.16, 95% CI 1.33–3.51, P = 0.002) compared with patients without UGIB. No significant publication bias was evident in the meta‐analysis. The results of our study indicate that UGIB in individuals with COVID‐19 is linked to negative outcomes such as severe illness, higher mortality rates, and an increased risk of re‐bleeding. These findings highlight the significance of identifying UGIB as a significant complication in COVID‐19 cases and emphasise the importance of timely clinical assessment and proper treatment.

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Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Cited by 32 publications

References 55 publications

N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues

N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues

Antioxidant and Anti-Inflammatory Potential of Thymoquinone and Lycopene Mitigate the Chlorpyrifos-Induced Toxic Neuropathy

Prevalence and outcomes of upper gastrointestinal bleeding in COVID‐19: A systematic review and meta‐analysis

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