Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis

Khalilian, Behnam; Madadi, Shabnam; Fattahi, Nima; Abouhamzeh, Beheshteh

doi:10.1007/s10735-020-09929-x

Cited by 19 publications

(6 citation statements)

References 56 publications

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“…Almost one-half of patients with MS display symptoms of depression (53). The depressive symptoms observed in patients with MS can precede the onset of neurological symptoms, suggesting that depression may be related to early disease-specific processes (54).…”

Section: Discussionmentioning

confidence: 99%

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

et al. 2022

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Depression is a common and disabling comorbidity of multiple sclerosis (MS), with currently no clear guidelines for treatment. Low-field magnetic stimulation (LFMS), a novel non-invasive neuromodulation intervention, has been previously demonstrated to rapidly alleviate mood disorders. The aim of the present study was to investigate the effects of LFMS on depression-like behaviors and demyelination in a well-established mouse model of MS. C57BL/6 female mice were fed a 0.2% cuprizone (CPZ) diet for 3 or 6 weeks to induce acute demyelination. During this time, the mice were treated with either sham or LFMS for 20 min/day, 5 days/week. After 3 or 6 weeks of treatment, behavior was assessed with the open field task, Y-maze and the forced swim test. The prefrontal cortex and hippocampus were then collected to perform immunohistochemistry and western blot analysis to verify myelination status. The CPZ diet did not cause significant locomotor deficits; however, working memory, measured using the Y maze, depression-like behavior and adaptive learning, assayed using the forced swim test, were significantly impaired in these animals. LFMS treatment demonstrated a significant antidepressant-like effect and markedly attenuated the CPZ-induced demyelination in the prefrontal cortex after 3-and 6-weeks of treatment, as observed by changes in myelin basic protein immunostaining and western blot analysis. Therefore, the results of the present study indicated that LFMS may be a promising therapy for demyelinating diseases due to the improvement of depressive symptoms via regulation of myelination in cortical areas.

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Section: Discussionmentioning

confidence: 99%

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

et al. 2022

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“…It attenuates CPZ-induced stress oxidative and inhibits inflammatory biomarkers. 87 CoQ10scavenged FA may be a critical reason for treating MS in this CPZ-model. 12 Similarly, in another autoimmune MS model of the experimental autoimmune encephalomyelitis (EAE), coQ10 can reduce the levels of IL-1, IL-6 and TNFα.…”

Section: Coq10 and Multiple Sclerosismentioning

confidence: 89%

Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases

Jin

et al. 2022

Am J Alzheimers Dis Other Demen

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Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cognitive impairments. Unexpectedly, an amount of formaldehyde has been detected in the brains. Multiple factors can induce the generation and accumulation of endogenous formaldehyde. Excessive formaldehyde can induce oxidative stress to generate H2O2; in turn, H2O2 promote formaldehyde production. Clinical investigations have shown that an abnormal high level of formaldehyde but low level of coenzyme Q10 (coQ10) was observed in patients with NDD. Further studies have proven that excessive formaldehyde directly inactivates coQ10, reduces the ATP generation, enhances oxidative stress, initiates inflammation storm, induces demyelination; subsequently, it results in neurodegeneration. Although the low water solubility of coQ10 limits its clinical application, nanomicellar water-soluble coQ10 exhibits positive therapeutical effects. Hence, nanopackage of coQ10 may be a promising strategy for treating NDD.

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“…SOD is rst line indicator for demyelination in the MS disease (Vodjgani et al 2020). CPZ by inhibiting SOD activity leads to mega mitochondria formation, perikaryon and myelin sheath degeneration (Khalilian et al 2021). Also, GPx acts as a donor to eliminate ROS and inhibiting oxidative damage to neurons and oligodendrocytes (Vodjgani et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice

Tashakori

Hassanpour

Vazir

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Crocin is the main bioactive components of the saffron with neuro generative and protective activity, however, its activity in neurodegenerative disease in not fully elicited. So, the aim of the current study was to determine effects of the crocin on re exive motor behavior, depressive and serum antioxidant activities on cuprizone-induced (CPZ) model of multiple sclerosis (MS) mice. 40 male C57BL/6 mice were randomly assigned into 4 groups. Mice in the control group were treated with normal diet. In group 2, CPZ-induced demyelination was done by chew palate containing 0.2% (w/w) CPZ for 5 weeks. In group 3, normal diet was provided and mice orally received crocin (100 mg/kg) 3 times per week for 5 weeks. In group 4, mice feed CPZ containing diet and orally received crocin (100 mg/kg) three times per for 5 weeks. At the end of the study, re exive motor behavior and depressive tests were done. Also, serum and brain tissue antioxidant activity was determined. According to the data, crocin had positive effects on hind-limb foot angle, hind-and front-limb suspension, surface righting, grip strength and negative geotaxis while CPZ had adverse effect compare to control group (P < 0.05). Co-administration of the CPZ + crocin signi cantly decreased adverse effect of the CPZ on the re exive motor behavior tests (P < 0.05).CPZ signi cantly increased immobility time in the forced swimming test (FST), tail suspension test (TST) and crocin diminished it (P < 0.05). Co-administration of the CPZ + crocin signi cantly decreased adverse effect of the CPZ on immobility time (P < 0.05). CPZ decreased number of cross in open eld test (OFT) and spending time on rotarod and CPZ + crocin signi cantly lessened adverse effect of the CPZ (P < 0.05). CPZ signi cantly increased malondialdehyde (MDA) and decreased glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) and these effects reversed by crocin in brain tissue and serum (P < 0.05). Co-administration of the CPZ + crocin signi cantly improved adverse effect of the CPZ on serum and brain tissue antioxidants (P < 0.05). These results suggested crocin has protective effect against on CPZ-induced MS in mice.

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Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis

Cited by 19 publications

References 56 publications

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

Low‑field magnetic stimulation improved cuprizone‑induced depression‑like symptoms and demyelination in female mice

Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases

Protective effect of crocin on cuprizone-induced model of multiple sclerosis in mice

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