Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants

Abstract

Coenzyme Q10(CoQ10) in human milk at different stages of maturity in mothers of preterm and full-term infants and its relation to the total antioxidant capacity of milk is described for the first time. Thirty healthy breastfeeding women provided colostrum, transition-milk and mature-milk samples. Coenzyme Q, alpha-, gamma- and delta-tocopherol, fatty acids and the total antioxidant capacity of the milk were analyzed. Coenzyme Q10 was found at higher concentrations for colostrum (0.81+/-0.06 vs. 0.50+/-0.05 micromol/l) and transition milk (0.75+/-0.06 vs. 0.45+/-0.05 micromol/l) in the full-term vs. the preterm group (similar results were found for total antioxidant capacity). Concentrations of alpha- and gamma-tocopherol were higher in the full-term group and decreased with time. In conclusion, CoQ10 is present in breast milk, with higher concentration in mothers of full-term infants. CoQ10 in breast milk decreases through lactation in mothers delivering full-term infants. Also, CoQ10, alpha- and gamma-tocopherol concentration in human milk directly correlates with the antioxidant capacity of the milk.

Facultative to strict anaerobes ratio in the preterm infant microbiota

“…Interestingly, breast milk from mothers of full-term infants has been found to have a higher antioxidant capacity than that of mothers of preterm babies. 30 These findings have prompted researchers to focus their attention on antioxidant supplementations in preterm babies by the use of non-enzymatic proteins, such as transferrin and ferritin, antioxidant enzymes or oxidizable molecules, including vitamins, fatty acids or aminoacids, among others, 26,27 for some of which positive results have been published. 31,32 Interestingly, probiotic microorganism could also play a role as antioxidants, since strains displaying this property have been reported 33 and probiotic metabolites able to prevent the production of proinflammatory cytokines induced by oxidative stress have been recently identified.…”

Scientific Opinion on Dietary Reference Values for vitamin E as α‐tocopherol

“…The other five studies (Schweigert et al, 2004;Quiles et al, 2006;Romeu-Nadal et al, 2006;SziklaiLaszlo et al, 2009;Antonakou et al, 2011) were conducted in mothers of full-term infants in the EU. In these studies, mean α-tocopherol concentration in human milk, measured by high-performance liquid chromatography (HPLC), ranged from about 3 mg/L to about 25 mg/L (including all stages of lactation).…”

Efecto de los arándanos sobre el estado oxidativo de la leche en madres con mastitis

“…Sin embargo, contrariamente a lo que esperábamos, y tras comparar la ingesta de macronutrientes observada en las madres con las ingestas recomendadas, la dieta de las mujeres estudiadas en todos los grupos era desequilibrada en lo que respecta al aporte de estos nutrientes, con un exceso de ingesta de grasas y proteínas en detrimento de la ingesta de hidratos de carbono (Tabla 8 y figura 27) (Bolton & Wooddward, 1994;Astrup & Raben, 1995;Fernández-Vergel et al, 2006;Quiles, 2006;Codoñer-Franch et al, 2013;Varela-Moreiras et al, 2013).…”

“…Este comportamiento es muy similar a los resultados obtenidos en los estudios realizados por Quiles y Codoñer-Franch (Quiles, 2006;Codoñer-Franch et al, 2013). Debemos de tener presente que la grasa poliinsaturada es un componente fundamental de la leche materna (Yahvah, 2015;Delplanque, 2015).…”

“…Estos resultados están en consonancia con los descritos en otros estudios realizados con animales, como el de Dimri y cols., en el que se observa que un suplemento con vitaminas A y E en búfalos con mastitis es capaz de atenuar la disminución de la CAT en leche (Dimri et al, 2013). Aunque a día de hoy no existe ningún estudio sobre la CAT en leche humana de madres con mastitis con o sin suplementos con antioxidantes, sí existen numerosos trabajos que han observado una disminución de la CAT de la leche materna a lo largo del tiempo, (Quiles, 2006;Ezaki, 2008;Mataix, 2008;Zarban, 2009;Codoñer-Franch et al, 2013;Nykniaz, 2013).…”