Cocoplum ( Chrysobalanus icaco L.) decreases doxorubicin-induced DNA damage and downregulates Gadd45a , Il-1β , and Tnf-α in vivo

Venâncio, Vinícius Paula; Almeida, Mara Ribeiro; Antunes, Lusânia Maria Greggi

doi:10.1016/j.foodres.2017.12.009

Cited by 8 publications

(4 citation statements)

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“…The proteomic characterization of the aqueous extract of C. icaco leaves confirmed the presence of enzymes involved in the glucose metabolic pathway [25]. The fruits studied by [39] indicated antioxidant activity in rats, in addition to reducing inflammation and DNA damage [40]. An extract of, C. icaco roots from material collected in Central Africa had two diterpenes, one of which showed inhibitory action on HIV-1 infected cells in vitro [16].…”

Section: Introductionmentioning

confidence: 81%

Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil

Fonseca-Kruel

Neves

Araújo

et al. 2020

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Background: Chrysobalanus icaco L. (Chrysobalanaceae) is a native but not endemic shrub species from Brazil. It is known as: abajirú, ajuru, bajirú, guajurú. There are ancient reports of edible fruits and leaves used in traditional medicine, mainly by the artisanal fishing communities of the Brazilian coast. It occurs especially in the coastal sand plains, situated between the Atlantic Ocean and the rainforest. However, in the last two decades this vegetation has been suffering strong anthropic pressures, which has led to the suppression of vegetation cover. This fact has impacted both the maintenance of plants and cultural diversity associated with it. Our study aimed to investigate current ethnobotanical knowledge about bajiru, an important species for the treatment of diabetes and recognized in the artisanal fishing communities of Southeastern Brazil to support conservation actions and sustainable management plan.Methods: This study was conducted with the artisanal fishermen community, near the Restinga de Massambaba, Brazilian costal vegetation and was supported by the signature and consent of all the fishermen involved. The collection of ethnobotanical information was performed using snowball technique, seeking artisanal fishermen who hold local knowledge, conversations and informal interviews based on rapport, semi-structured interviews and free listing. The Anthropac 4.0 software was used to calculate the highest citation frequency and highest salience among the repertoire of useful species indicated in the free listing. Complementary techniques were used: free walking with local experts for information triangulation and to collect botanical material. We used the Informant Consensus Factor (ICF) and Fidelity level (FL). Results: Interviews were conducted with 42 artisanal fishermens and bajiru was a preferred and useful species of current relevance (indicated by 32 of 42 fishermen). Its leaves are still used for diabetes treatments and with representative value of the informants' consensus in the studied sample (IFC = 0.78) and the level of fidelity of this use information (FL = 1).Conclusions: In our discussion we highlight the importance of bajiru as a potential for future studies for diabetes. Should the use of bajiru increase comercially greater plans for the conservation and possible cultivation of this specie will be needed.

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Section: Introductionmentioning

confidence: 81%

Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil

Fonseca-Kruel

Neves

Araújo

et al. 2020

Preprint

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“…The leaf extract (tea) of the plant Chrysobalanus icaco L., a species of restinga 41 popularly known as abajerú, is used in folk medicine because it exerts biological 42 activities, such as the decrease of blood sugar levels, being indicated for the treatment of 43 diabetes, besides be diuretic and antioxidant (Venancio et al, 2018). Another plant 44 (Eugenia astringens, Cambess.)…”

Section: Introduction 32 33mentioning

confidence: 99%

A preliminary study of the cytotoxicity of the protein extract of Chrysobalanus icaco L. and Eugenia astringens Cambess., commercialized in markets

Pedrete

Carmo

Barreto

et al. 2019

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12The use of plants and their products for medical treatment is very common 13 procedure in Brazil, especially for treatment of diabetes. In fact, several plants can 14 demonstrate hypoglycemic effects in vitro assays. However, the use for human 15 treatment requires the knowledge of their toxicological properties. The aim of this study 16 was to evaluate the effect of protein extracts of Chrysobalanus icaco collected from 17 natural habitats and of Eugenia astringens acquired from the market of Rio de Janeiro 18 on the viability and migration of fibroblasts. E. astringens has a similar morphology as 19 C. icaco and it is sold as Chrysobalanus in a popular market in Rio de Janeiro. Being a 20 different plant, E. astringens expresses different proteins, and its protein extract has 21 proved to possess higher toxic properties than C. icaco does. Cytotoxicity assays 22 indicated that, as the protein extract concentration increases, fibroblast viability 23 decreases. Only the E. astringens extract displayed cytotoxicity at all concentrations, in 24 addition to reduced fibroblast migration. The results obtained in this study demonstrates 25 that it's necessary integrative policies for rational use of medicinal plants and their 26 commercialization, since the current use of medicinal plants may be inadequate and it is 27 of great importance for Public Health. 28

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“…CP has therapeutic properties that are beneficial to health, including reducing inflammation and skin disorder caused by oxidative stress and fake skincare products. The cocoplum leaves have antifungal, analgesic, and hypoglycemic properties [14], which can also be incorporated in the pharmaceutical ointment for fungi infection. The evergreen tree in the family Chrysobalanus that has sweet-smelling flavors and the fruit is edible.…”

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confidence: 99%

“…The tree grows up to 9 m (30 feet) tall, and it has roundish shiny green leaves and clusters of white flowers. Reports have shown that cocoplum has many health benefits, such as improving the functionality of the human eye, cancer treatment, reduces the risk of stroke and heart attack [14], [15]. Cocoplum seed is useful for pregnant women, and consumption after childbirth purifies the blood.…”

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confidence: 99%

Extraction and Formulation of Oil in Water (O/W) Emulsion with Coco Plum (Chrysobalanus icaco) Seed Oil: Physicochemical and Microbiological Evaluations

2020

SETWM-20, ACBES-20 &Amp; EEHSS-20 Nov. 16-17, 2020 Johannesburg (SA)

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The emulsion instability and macroscopic phase separation of oil in water (O/W) emulsion have become a significant concern globally as it poses lots of threat to human skin. Several mechanisms involved in emulsion instability include the rupture of oil globules or coalescence of the internal water droplets. The present study aimed to formulate oil in water (O/W) emulsion by entrapping 5% of cocoplum oil extract in increasing order (0,10,15 and 20) into the oil phase of the emulsion. The base form contains the paraffin oil (20,10,15 and 0) in decreasing order. Rosemary extract was incorporated as a fragrance to the emulsion. Both the base (B) and formulations (FA, FB, and FC) were stored at 8°C (in a refrigerator) and at 30 o C (room temperature) for 35 days to investigate their stability, color, smell, phase separation without agitation, phase separation under centrifugation, liquefaction, pH. The microbiological evaluations (Aerobic plate count) were investigated with an acceptable standard. The findings indicate that the formulation with only cocoplum oil extract (FC) shows good resistance to stability and macroscopic phase separation. The microbiological evaluation indicates no significant growth of microorganisms at dilution 10 -4 and 10 -6 after 48hrs of the incubation period. Further sub-cultured within 35 days produces 0.2log10CFU/g, which does not exceed 6.9log10CFU/g recommended by ISO NF-21149, 2009 for cosmetics analysis. The newly formulated oil in water (O/W) emulsion has a promising property that might eradicate skin diseases. Also, it may open new opportunities for the formulation of more active, safe, and cost-effective cosmetics and pharmaceutical formulations.

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Cocoplum ( Chrysobalanus icaco L.) decreases doxorubicin-induced DNA damage and downregulates Gadd45a , Il-1β , and Tnf-α in vivo

Cited by 8 publications

References 50 publications

Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil

Ethnobotany of Bajiru (Chrysobalanus Icaco L.) In a Coastal Vegetation of Southeastern Brazil

A preliminary study of the cytotoxicity of the protein extract of Chrysobalanus icaco L. and Eugenia astringens Cambess., commercialized in markets

Extraction and Formulation of Oil in Water (O/W) Emulsion with Coco Plum (Chrysobalanus icaco) Seed Oil: Physicochemical and Microbiological Evaluations

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