CO2-laser therapy in patients with vulvar intraepithelial neoplasia

Helmerhorst, Th.J.M.; Vaart, C. H. van der; Dijkhuizen, G.H.; Calame, J.J.; Kenemans, P.; Stolk, J.

doi:10.1016/0028-2243(90)90018-v

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…We found 61.1% of patients with multifocal/multicentric lesions required more than two treatments compared to 32% of those with unifocal lesions respectively (P < 0.05). This finding is not surprising, since the multifocal/multicentric lesions are probably reflecting more aggressive disease (3). Others have reported a higher recurrence rate and treatment failure due to incomplete treatment and the missing of some lesions, and therefore suggested that simple vulvectomy should be done in selective multifocal/multicentric lesions (11"1s'16).…”

Section: Discussionmentioning

confidence: 82%

“…Although progression to invasive vulvar cancer is not established, up to 25% of invasive vulvar carcinomas occur adjacent to areas of VIN III and 30% may also have an associated cervical dysplasia or cervical cancer. Different treatment modalities for VIN have been suggested, including laser vaporization and wide local excision, which have been found to be both safe and efficient (3) .…”

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confidence: 99%

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Vulvar intra-epithelial neoplasia-treatment outcome

David¹,

Lickrish²,

Rosen³

et al. 1996

Int J Gynecol Cancer

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One hundred and two patients with vulvar intra‐epithelial neoplasia III (VIN III) were analyzed with respect to age, sites of lesion, presence of human papilloma virus (HPV) and recurrence pattern following different treatment modalities. Recurrences were documented in 64% of patients. Patients treated with local excision had a statistically significant lower recurrence rate compared to those who underwent laser vaporization (29% vs 55.8% correspondingly). Recurrence rates were also significantly higher in patients with multifocal/multicentric lesions (P < 0.05). A group of young, HPV‐positive patients with multifocal/multicentric lesions had the highest recurrence rate. Our data suggest that VIN III should be followed for a long period of time and that a prospective study is required to clarify the effectiveness of the different treatment modalities.

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Section: Discussionmentioning

confidence: 82%

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confidence: 99%