Co-Infection of Hepatitis B Virus and Hepatitis Delta Virus in Yaounde-Cameroon

Torimiro, Judith; Monamele, Gwladys Chavely; Kowo, Mathurin; Takou, Désiré; Pouokam, Guy-Bertrand; Fokam, Joseph; Njoya, Oudou

doi:10.9734/bmrj/2014/6894

Cited by 3 publications

(8 citation statements)

References 15 publications

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“…In our series, the mean age in AC HDV positive patients is 37.2 ± 12.3 and in AC HDV negative patients is 35.4 ± 12.4 with a non-significant difference (p=0. 8), which is consistent with the results from Cameroon (p>0.05) [22] and the results from Tunisia, the mean age in AC HDV positive patients is 43 years and in AC HDV negative patients is aged 41 with a non-significant difference (p=0.12) [14]. However, these results are not consistent with the results obtained in blood donors in Mauritania, which shows that the average age was significantly higher in AC HDV positive donors compared to AC HDV negative donors (34.28 years ± 9.18 against 30.52 years ± 8.63, P = 0.001) [5] and are not consistent with the results of patients chronically infected with HBV followed at the National Hospital Center of Nouakchott (CHN) which shows that AC HDV positive patients were significantly older than AC HDV negative patients (41 ± 12 versus 33 ± 11 years, p < 0.001) [19].…”

Section: Agesupporting

confidence: 92%

“…The average age of Algerian patients is similar to that of our patients, 35 years [21], 39 years in Moroccans [20], 28 years in Tunisians [14], 33 years among Cameroonians [22] and 32 years among Nigerians [12]. The average age of our patients is consistent with that found in France, 36 years [23].…”

Section: Agesupporting

confidence: 87%

“…In Cameroon, a study was carried out in the Gastroenterology Unit of the Yaoundé University Hospital Center, the Yaoundé General Hospital and the Cathedral Medical Center, from August 2012 to May 2013 on 128 patients chronically infected with HBV notes a male predominance of which 77 (60.16%) were men and 51 (39.84%) were women [22].…”

Section: Gendermentioning

confidence: 99%

“…In Cameroon out of 128 patients chronically infected with HBV, 29 patients had positive HDV AC representing 22.66% [22]. In Nigeria, HDV AC was found in 12.5% of 96 HBsAg+ patients [26].…”

Section: Prevalence Of Hbv/hdv Co-infectionmentioning

confidence: 99%

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Hepatitis B and Delta Co-Infection: Prevalence and Serological Characteristics in Mauritania

SALEM¹,

Abdalla²,

Mohamed³

2022

JGMCP

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Background: Hepatitis B is one of the major public health concerns worldwide. In Mauritania, its prevalence in the general population is very high. The hepatitis D virus (HDV) borrows the envelope from the hepatitis B virus (HBV) during its infectious cycle. We thus observe co-infections during which the two viruses are acquired simultaneously and superinfections by HDV in patients who are already chronic carriers of the B virus. Objective: to assess the prevalence of HBV and HDV infection Material and Methods: this is a prospective descriptive study, conducted from January 1 to November 30, 2017 in the two medical analysis laboratories in Nouakchott. Patients were included: all patients of both sexes and of all ages carrying HBsAg presenting to the two medical analysis laboratories during this period. Results: in 1 month, 211 patients with HBsAg were notified out of a total of 1675 patients screened, i.e. a prevalence of 12.59%. HBV/HDV co-infection is 31.30%. The average age was 36 years with extremes [8 and 66]. The male/female sex ratio was 1.45. The mean HBV viral load was 2.68 ± 1.31 log IU/ml [range: 478.63 IU/ml ± 20.41]. The majority (94.9%) of patients were HBeAg negative. Conclusion: HBV/HDV co-infection remains very high in our country. This study indicates that the significant morbidity of the two viruses associated with limited knowledge of the mode of transmission, constitute factors of vulnerability.

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Section: Agesupporting

confidence: 92%

Section: Agesupporting

confidence: 87%

Section: Gendermentioning

confidence: 99%

“…In Cameroon out of 128 patients chronically infected with HBV, 29 patients had positive HDV AC representing 22.66% [22]. In Nigeria, HDV AC was found in 12.5% of 96 HBsAg+ patients [26].…”

Section: Prevalence Of Hbv/hdv Co-infectionmentioning

confidence: 99%

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Hepatitis B and Delta Co-Infection: Prevalence and Serological Characteristics in Mauritania

SALEM¹,

Abdalla²,

Mohamed³

2022

JGMCP

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“…Methodological approaches can explain the differences in our study, the seroprevalence of the anti-HDV antibody is 12.2%. This prevalence is low compared to those reported in the subregion by Foupouapouognigni et al and 22.6% [14] [15]. These high prevalences could be explained by selection bias in patient recruitment.…”

Section: Discussioncontrasting

confidence: 59%

Seroprevalence and Molecular Biodiversity of Hepatitis B and Delta Virus Infections in the Republic of Congo

Mongo-Onkouo¹,

Okombi²,

Boumba³

et al. 2018

OJGas

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Hepatitis B virus (HBV) infection is a major public health problem in the world. In Congo, studies on the prevalence of HBV infection are common but HDV infection is rare. Objective: Contribute to improve the management and prevention of HBV and HDV infections. Patients and Methods: This was a descriptive and cross-sectional study conducted from January to August 2016 in the health services of the various departments of Congo and at the national public health laboratory in Brazzaville. All patients with HBsAg surface antigen who were at least 18 years old and who consented to the study were included. The HBs antigen was first tested by a rapid test then confirmed by ELISA. All HBsAg positive patients were subsequently subjected to a second ELISA test for Delta antibody. The techniques of extraction and conventional and specific gene amplification were carried out on plasma for the identification of the genotypes of the two viruses. The data analysis was done with EpiInfo V7 software. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. Results: 1618 subjects were included, of whom 180 were positive for HBsAg, a frequency of 11.12%. The sex ratio (M/F) was 0.77%, the mean age was 40.2 ± 15.6 years with extremes ranging from 18 to 88 years. Of the 180 HBsAg positive, 22 were anti-VHD positive, a frequency of 12.22%. HBV DNA was amplified in 83.8% (151/180), HDV RNA in 63.6% (14/22). For HBV, three genotypes were identified: E (46.9%), A (43.7%) and D (9.4%), however for VHD three genotypes D1, D5, D8 were identified. Conclusion: Co-infection of hepatitis

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Evolutionary trends in the prevalence of anti-HDV antibodies among patients positive for HBsAg referred to a national laboratory in Cameroon from 2012 to 2017

et al. 2019

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Objective The aim of this study was to update the data on the prevalence of anti-HDV antibodies in Cameroon. Results Antibodies against hepatitis Delta virus (Anti-HDV) were found in 16.48% (95% CI 11.46–18.77%) of 426 hepatitis B virus surface antigen positive patients in Cameroon. Remarkably, they were significantly higher among people over 40 years and those living in the East and South regions of Cameroon at 66.7%, 50%, and 40%, respectively. These results suggest that older age and living in areas in the dense forest may be risk factors for Hepatitis D infection.

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Co-Infection of Hepatitis B Virus and Hepatitis Delta Virus in Yaounde-Cameroon

Cited by 3 publications

References 15 publications

Hepatitis B and Delta Co-Infection: Prevalence and Serological Characteristics in Mauritania

Hepatitis B and Delta Co-Infection: Prevalence and Serological Characteristics in Mauritania

Seroprevalence and Molecular Biodiversity of Hepatitis B and Delta Virus Infections in the Republic of Congo

Evolutionary trends in the prevalence of anti-HDV antibodies among patients positive for HBsAg referred to a national laboratory in Cameroon from 2012 to 2017

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