Evolutionary trends in the prevalence of anti-HDV antibodies among patients positive for HBsAg referred to a national laboratory in Cameroon from 2012 to 2017

Noubissi-Jouegouo, Laurence; Atsama, Marie Amougou; Tagnouokam-Ngoupo, Paul Alain; Monamele, Chavely Gwladys; Ngono, Laure; Njouom, Richard

doi:10.1186/s13104-019-4460-4

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…A recent publication evaluating HBV and HDV epidemiology from Yakutia, Russia reported increasing HDV population in connection with a stable HBV prevalence [ 37 ]. Similar patterns of HDV incidence were also reported in Cameroon, Austria, and United States [ 38 – 41 ]. These reported shifts in HDV incidence mirror some of the structural breaks observed in our analyses.…”

Section: Discussionsupporting

confidence: 81%

A changing landscape: Tracking and analysis of the international HDV epidemiology 1999–2020

Fallon

Cooke

Hesterman

et al. 2023

PLOS Glob Public Health

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The international epidemiology of Hepatitis Delta Virus (HDV) is challenging to accurately estimate due to limited active surveillance for this rare infectious disease. Prior HDV epidemiological studies have relied on meta-analysis of aggregated and static datasets. These limitations restrict the capacity to actively detect low-level and/or geographically dispersed changes in the incidence of HDV diagnoses. This study was designed to provide a resource to track and analyze the international HDV epidemiology. Datasets analyzed collectively consisted of >700,000 HBV and >9,000 HDV reported cases ranging between 1999–2020. Datasets mined from government publications were identified for Argentina, Australia, Austria, Brazil, Bulgaria, Canada, Finland, Germany, Macao, Netherlands, New Zealand, Norway, Sweden, Taiwan, Thailand, United Kingdom, and United States. Time series analyses, including Mann-Kendall (MK) trend test, Bayesian Information Criterion (BIC), and hierarchal clustering, were performed to characterize trends in the HDV timelines. An aggregated prevalence of 2,560 HDV/HBV100,000 cases (95% CI 180–4940) or 2.56% HDV/HBV cases was identified, ranging from 0.26% in Canada to 20% in the United States. Structural breaks in the timeline of HDV incidence were identified in 2002, 2012, and 2017, with a significant increase occurring between 2013–2017. Significant increasing trends in reported HDV and HBV cases were observed in 47% and 24% of datasets, respectively. Analyses of the HDV incidence timeline identified four distinct temporal clusters, including Cluster I (Macao, Taiwan), Cluster II (Argentina, Brazil, Germany, Thailand), Cluster III (Bulgaria, Netherlands, New Zealand, United Kingdom, United States) and Cluster IV (Australia, Austria, Canada, Finland, Norway, Sweden). Tracking of HDV and HBV cases on an international scale is essential in defining the global impact of viral hepatitis. Significant disruptions of HDV and HBV epidemiology have been identified. Increased surveillance of HDV is warranted to further define the etiology of the recent breakpoints in the international HDV incidence.

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Section: Discussionsupporting

confidence: 81%

A changing landscape: Tracking and analysis of the international HDV epidemiology 1999–2020

Fallon

Cooke

Hesterman

et al. 2023

PLOS Glob Public Health

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“…HDV prevalence in HBV positive patients fluctuated from 2•15% in 2004 to 1•28% in 2010, then back up to 3•47% in 2014, before declining again to 0•89% in 2016 31 . Similar patterns of HDV incidence were also reported in Cameroon by Noubissi-Jouegouo, et al and in multiple datasets from the United States [32][33][34] . These reported shifts in HDV incidence mirror some of the structural breaks observed in our analyses.…”

Section: Secondary Cluster Analysis Further Identified Four Distinct Temporal Patterns Of Hdv/hbv Diagnoses Includingsupporting

confidence: 86%

Significant Structural Breaks in the International Incidence of Hepatitis Delta Virus

Fallon

Cooke

Hesterman

et al. 2021

Preprint

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The international incidence of Hepatitis Delta Virus (HDV) is challenging to accurately estimate due to the limited testing and lack of active surveillance for this rare infectious disease. These limitations prevent the detection of low-level and/or geographically dispersed changes in the incidence of HDV diagnoses. A study was designed to enable international active tracking and analyses of HDV epidemiology by aggregating global HDV diagnoses datasets. Publicly accessible datasets containing yearly incidence for HDV and Hepatitis B Virus (HBV) diagnoses were identified for Argentina, Australia, Austria, Brazil, Bulgaria, Canada, Finland, Germany, Macao, Netherlands, New Zealand, Norway, Sweden, Taiwan, Thailand, United Kingdom, and United States. Aggregated analysis of these HDV and HBV datasets spanning 1999-2020 identified structural breaks in the timeline of HDV incidence in 2002, 2012, and 2017. A significant increase in the international HDV incidence, relative to reported HBV diagnoses, occurred in 2013-2017. Secondary analysis identified four distinct temporal clusters of HDV incidence, including Cluster I (Macao, Taiwan), Cluster II (Argentina, Brazil, Germany, Thailand), Cluster III (Bulgaria, Netherlands, New Zealand, United Kingdom, United States), and Cluster IV (Australia, Austria, Canada, Finland, Norway, Sweden). Additionally, analyses of available demographic data identified a decreasing trend of HDV diagnoses in patients 0-19 years of age and an increasing trend of HDV diagnoses in patients ≥60 years of age. Re-evaluation of the testing paradigm for HDV in HBV-positive patients and an active surveillance status of HDV are warranted to define the etiology of the observed international shifts in HDV incidence.

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“…In the only other study done in Cuba in 1988, an anti-HDV positivity of 8.3% was detected ( 11 ). While we cannot exclude false positive results in the previous study, the ELISA kit used in the present study is expected to reliably detect HDV antibodies with reported sensitivity and specificity values of above 98% ( 16 ). The difference may be related to the success of the Cuban hepatitis B prevention and control program, since HBV vaccination is the most influential factor concerning the prevalence of both diseases ( 17 ).…”

Section: Discussionmentioning

confidence: 65%

Low prevalence of hepatitis delta infection in Cuban HBsAg carriers: Prospect for elimination

Lay

Tan²,

Villalba³

et al. 2023

Front. Med.

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IntroductionInfection with hepatitis delta virus (HDV) is one of the most severe hepatitis B virus (HBV) complications, with a more rapid progression to cirrhosis and an increased risk of hepatic decompensation and death. Data on HDV infection in Cuba are limited. The aims of our study were to determine the HDV prevalence in HBsAg carriers and to characterize the HDV strains circulating. The data were used to assess the possibility of HDV elimination in the Cuban HBV epidemiological setting.MethodsFive hundred and two serum samples from the same number of HBsAg carriers collected in the period 2006–2019 from all over the country were tested for anti-HDV total antibodies. If positive, the samples were analyzed for HDV-RNA using Real-Time RT-PCR targeting the ribozyme and HD antigen domains followed by genotyping based on phylogenetic analysis.ResultsTwo samples were anti-HDV positive [0.39% (95% CI 0.11–1.44)]. One of them was also HDV-RNA positive. Clinically, the patient with active HDV infection had compensated liver cirrhosis. Phylogenetic analysis showed that the virus belonged to genotype 1 and thus clustered with contemporary strains from North America, Europe, Middle East, and Asia.DiscussionThis is the first HDV study, including molecular detection and virus characterization, done after the introduction of the universal childhood anti-hepatitis B vaccination. The very low prevalence of HDV infection in HBsAg carriers combined with the high HBV vaccination coverage of all newborn children, of previously identified risk groups, and of the general population currently under 40 years of age suggests that HDV elimination is feasible in Cuba if the success in HBV control is maintained.

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Evolutionary trends in the prevalence of anti-HDV antibodies among patients positive for HBsAg referred to a national laboratory in Cameroon from 2012 to 2017

Cited by 7 publications

References 14 publications

A changing landscape: Tracking and analysis of the international HDV epidemiology 1999–2020

A changing landscape: Tracking and analysis of the international HDV epidemiology 1999–2020

Significant Structural Breaks in the International Incidence of Hepatitis Delta Virus

Low prevalence of hepatitis delta infection in Cuban HBsAg carriers: Prospect for elimination

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