Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial

Zurbau, Andreea; Duvnjak, Lea; Magaš, Saša; Jovanovski, Elena; Miočić, Jelena; Jenkins, Alexandra L.; Jenkins, David; Josse, Robert G.; Leiter, Lawrence A.; Sievenpiper, John L.; Vuksan, Vladimir

doi:10.1007/s00394-020-02434-7

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…Chia seeds oil possessed anti-inflammatory and cholesterol-lowering activities (18). Chia seeds attenuated postprandial blood glucose, increased satiety, increased weight reduction, and reduced inflammatory markers and cardiovascular risk factors due to the presence of omega-3 fatty acids and dietary fibers (22).…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that the recommended daily intake of phytosterols is 2 g/d for lowering the risk of chronic diseases (21). Chia seeds (Salvia hispanica L.) are the richest source of dietary fibers and omega-3 fatty acids, also rich in protein, minerals, and vitamins (22). Dietary fibers (mucilaginous polysaccharide/gum) are represented by 34%-36% in chia seeds, which is higher than many fruits, vegetables, or cereals (23).…”

Section: Introductionmentioning

confidence: 99%

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Chia seeds oil enriched with phytosterols and mucilage as a cardioprotective dietary supplement towards inflammation, oxidative stress, and dyslipidemia

Mohamed

Mohammed

Hamed

2021

J Herbmed Pharmacol

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Introduction: Non-communicable diseases are a cluster of metabolic diseases, which include type-2 diabetes, cancer, and cardiovascular diseases (CVDs). The aim of the current research was to incorporate dietary fibers (mucilage) and phytosterol for enriching chia seeds oil for producing new dietary supplements for cardio-protection from oxidative stress, inflammation, and dyslipidemia. Methods: Fatty acids profile, phytosterols, and phenolic compounds content of the prepared dietary supplement were assessed. The cardioprotective potency of the dietary supplement was evaluated in rats fed on a high-fat diet for a month. Biochemical parameters related to inflammation, oxidative stress, lipid profile, cardiac enzymes, and kidney function were determined in all rats. Results: The results revealed that dietary supplement was rich in omega-3 fatty acids. Beta-sitosterol and campesterol were the major phytosterols in chia seeds oil dietary supplement. Phenolic compounds were present by 25.9 ± 1.202 mg gallic acid equivalent (GAE)/g dietary supplements. Rats fed on the high-fat diet showed significant elevation (P < 0.05) in inflammatory markers, oxidative stress, dyslipidemia, and cardiac enzymes in association with the elevation of kidney function compared with normal rats. Administration of both doses of dietary supplement significantly (P < 0.05) improved all the studied biochemical parameters. The high dose of the dietary supplement was promising in the reduction of inflammatory markers, oxidative stress, and improved dyslipidemia in accordance with the reduction of all cardiac enzymes and kidney function. Conclusion: Dietary supplements investigated in the current research showed cardioprotective potency through its anti-inflammatory and dyslipidemic activities, which may be attributed to the presence of phenolic compounds, omega-3 fatty acids, phytosterols, and soluble dietary fibers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chia seeds oil enriched with phytosterols and mucilage as a cardioprotective dietary supplement towards inflammation, oxidative stress, and dyslipidemia

Mohamed

Mohammed

Hamed

2021

J Herbmed Pharmacol

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“…Of those, 1236 RCTs were not relevant to the subject, leaving 202 records eligible for full-text review. Furthermore, after excluding 6 studies examining the impact of ginseng in combination with other ingredients due to the impossibility of determining the independent effect of ginseng [43][44][45][46][47][48], 3 eligible studies which reported in a language other than English [49][50][51], 1 study with multiple-crossover, acute dose escalation design [52], and 172 records which did not provide sufficient data and/or did not fulfill the inclusion criteria, 20 RCTs with 24 effect sizes met the inclusion criteria for qualitative synthesis.…”

Section: Study Selectionmentioning

confidence: 99%

The Efficacy of Ginseng (Panax) on Human Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

et al. 2022

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Results from different clinical trials on the effects of ginseng on prediabetes and type 2 diabetes (T2DM) are still inconsistent. To fill this knowledge gap, we investigated the overall effects of ginseng supplementation on improving cardiometabolic biomarkers among these patients. A systematic literature search was conducted on PubMed/MEDLINE, Scopus, Web of Science, and Cochrane library. A random-effect model was applied to estimate the weighted mean difference and 95% CI for each outcome. Overall, 20 eligible RCTs were included. Meta-analyses revealed that ginseng supplementation significantly reduced serum concentration of FPG, TC, IL-6, and HOMA-IR values. It also increased HR and TNF-α levels. Ginseng supplementation changed HOMA-IR and HDL-C significantly based on dose and changed HOMA-IR and LDL-C significantly based on study duration in a non-linear fashion. Furthermore, meta-regression analyses indicated a linear relationship between ginseng dose and absolute changes in HDL-C. Moreover, subgroup analyses showed that ginseng supplementation changed TC and LDL-C when the supplementation dose was ≥2 g/day. Our findings suggest that ginseng supplementation may be an effective strategy for improving cardiometabolic profiles in individuals with prediabetes and T2DM.

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“…En otro ensayo clínico aleatorizado, en 42 pacientes con diabetes mellitus tipo 2 (DM2) la ingesta de semilla de chía (40 g/día por 12 semanas) generó una disminución significativa en la presión sistólica mientras que el perfil lipídico, peso corporal, marcadores inflamatorios y glicemia no cambiaron significativamente 20 . De la misma manera, en un ensayo clínico aleatorizado doble ciego, donde se suplementaron a 44 pacientes con DM2, con una cápsula que contenía fibra viscosa, chía y extracto de ginseng americano y coreano, durante 24 semanas, se generó una mejora en el control glicémico, atenuando el incremento de la hemoglobina glicosilada (HbA1c) y el perfil insulinémico 21 . Otro estudio en pacientes sanos que recibieron 50 g de glucosa con 25 g de semilla de chía en tres ocasiones, se produjo una reducción del pico glicémico, aumentando el tiempo hasta alcanzarlo, posiblemente mediado por la viscosidad que le otorga la fibra.…”

Section: Chía Y Beneficios En Humanos Salud Cardiovascular Y Alteraci...unclassified

Composición química, características nutricionales y beneficios asociados al consumo de chía (Salvia hispanica L.)

et al. 2022

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Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind randomized controlled trial

Cited by 10 publications

References 43 publications

Chia seeds oil enriched with phytosterols and mucilage as a cardioprotective dietary supplement towards inflammation, oxidative stress, and dyslipidemia

Chia seeds oil enriched with phytosterols and mucilage as a cardioprotective dietary supplement towards inflammation, oxidative stress, and dyslipidemia

The Efficacy of Ginseng (Panax) on Human Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Composición química, características nutricionales y beneficios asociados al consumo de chía (Salvia hispanica L.)

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