CMOS on-chip bio-imaging sensor with integrated micro light source array for optogenetics

Tokuda, Takashi; Kimura, Hiromi; Miyatani, Tomoaki; Maezawa, Yasuyo; Kobayashi, Takuma; Noda, Toshihiko; Sasagawa, Kiyotaka

doi:10.1049/el.2011.4087

Cited by 23 publications

(20 citation statements)

References 6 publications

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“…However, as shown in the inset of Fig. 3 (a), the anode and cathode electrodes of the LEDs are not transparent, which causes shadows in the captured images [13]. The structure of the TSV chip with integrated GaInN LEDs, which is used as the functional interface chip in the optoelectronic-type device was shown in Fig.…”

Section: Preparation Of the Functional Interface Chipsmentioning

confidence: 99%

“…The illumination intensity of more than 50 mW/mm 2 is one of the promising features of the device when used as an optical stimulator for optogenetics. Furthermore, taking advantage of the on-chip optical imaging, we can observe the operation of the optical stimulation function based on the position of the activated LED or the intensity of the LED emission [13]. In in vivo applications, this functionality is considerably advantageous when the device is fully implanted in the animal's body.…”

Section: In Vitro Demonstration Of On-chip Optical Neural Stimulationmentioning

confidence: 99%

“…x-y-matrix-type addressing was widely used in the preceding studies [11], [12]. On the other hand, we have proposed and demonstrated CMOSbased random-access capabilities [13]. We designed a multifunctional CMOS image sensor that has addressable surface electrodes.…”

Section: Introductionmentioning

confidence: 99%

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CMOS-Based Optoelectronic On-Chip Neural Interface Device

Tokuda

Takehara

Noda

et al. 2016

IEICE Trans. Electron.

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SUMMARYOn-chip neural interface devices based on CMOS image sensor technology are proposed and demonstrated. The devices were designed with target applications to optogenetics in bioscience. Multifunctional CMOS image sensors equipped with an addressable on-chip electrode array were integrated with a functional interface chip that contained embedded GaInN light emitting diodes (LEDs) and electrodes to create a neural interface. Detailed design information regarding the CMOS sensor chip and the functional interface chip including the packaging structure and fabrication processes are presented in this paper. The on-chip optical stimulation functionality was demonstrated in an in vitro experiment using neuron-like cells cultured on the proposed device.

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Section: Preparation Of the Functional Interface Chipsmentioning

confidence: 99%

Section: In Vitro Demonstration Of On-chip Optical Neural Stimulationmentioning

confidence: 99%

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CMOS-Based Optoelectronic On-Chip Neural Interface Device

Tokuda

Takehara

Noda

et al. 2016

IEICE Trans. Electron.

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“…Optical stimulation has been used in the studies of optogenetics. [17][18][19] For example, ultraviolet light was used to activate nerve cells. Because the plasma contains various ranges of optical emissions (infrared, visible, ultraviolet), they can be used for controlling cell activities.…”

Section: Introductionmentioning

confidence: 99%

Development of plasma-on-chip: Plasma treatment for individual cells cultured in media

Kumagai

Chang

Jeong

et al. 2015

Jpn. J. Appl. Phys.

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A device consisting of Si microwells and microplasma sources has been fabricated for plasma treatment of individual cells cultured in media. We named the device plasma-on-chip. The microwells have through-holes at the bottom where gas–liquid interfaces form when they are filled with media containing biological samples. The microplasma sources, which supply reactive species, are located on the back of each microwell. Through the gas–liquid interface, the reactive species are supplied to the cells. Chlorella cells were used to demonstrate the feasibility of the device and after three minutes of plasma treatment, the fluorescence intensity of Chlorella cells appeared to be decreased. Optical emission spectroscopy identified O and OH radicals in the plasma, which can affect the cells. In the analysis of biological samples such as human cells or tissues, this device raises the possibility of revealing the mechanisms of plasma medicine in more detail.

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“…We have proposed and demonstrated a CMOS-based optoelectronic neural interface device with an integrated LED array for on-chip stimulation [6,7]. Figure 1 shows the concept of the CMOS-based neural interface device.…”

Section: Introductionmentioning

confidence: 99%

An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics

Tokuda

Nakajima

Maezawa

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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A CMOS-based neural interface device equipped with an integrated micro light source array for optogenetics was fabricated and demonstrated. A GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor that is capable of on-chip current injection. We demonstrated a functionality of light stimulation onto ChR2-expressed cells in an in vitro experiment. A ChR2-expressed cell were successfully stimulated with the light emitted from the fabricated device.

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CMOS on-chip bio-imaging sensor with integrated micro light source array for optogenetics

Cited by 23 publications

References 6 publications

CMOS-Based Optoelectronic On-Chip Neural Interface Device

CMOS-Based Optoelectronic On-Chip Neural Interface Device

Development of plasma-on-chip: Plasma treatment for individual cells cultured in media

An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics

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