CMOS-Based Optoelectronic On-Chip Neural Interface Device

Abstract

SUMMARYOn-chip neural interface devices based on CMOS image sensor technology are proposed and demonstrated. The devices were designed with target applications to optogenetics in bioscience. Multifunctional CMOS image sensors equipped with an addressable on-chip electrode array were integrated with a functional interface chip that contained embedded GaInN light emitting diodes (LEDs) and electrodes to create a neural interface. Detailed design information regarding the CMOS sensor chip and the functional interface chip including the packaging structure and fabrication processes are presented in this paper. The on-chip optical stimulation functionality was demonstrated in an in vitro experiment using neuron-like cells cultured on the proposed device.

Perspective chapter: Optoelectronics for neural interfaces

“…These light sources include light emitting diodes (LEDs) or lasers that emit light when powered by electricity [26]. There have been recent developments of implants with LDs and LEDs assembled or monolithically integrated on silicon based as well as polymer-based substrates [18,[27][28][29][30].…”

Neural Monitoring With CMOS Image Sensors

“…To reduce the power consumption, intra-body communication technique is developed, which reduces power consumption and device size ( Tagawa et al, 2009 ; Takehara et al, 2016 ). Intra-body communication is a wireless data transmission technique, where an imaging system transmits electric signals through body tissues ( Tokuda et al, 2014 ; Tokuda, Takehara, Noda, Sasagawa, & Ohta, 2016 ; Yamagiwa, Ishida, & Kawano, 2015 ; Yamaguchi et al, 2016 ).…”