Integrated optoelectronic microprobes

Rudmann, Linda; Alt, MT; Vajari, Danesh Ashouri

doi:10.1016/j.conb.2018.01.010

Cited by 19 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of high-channel count implantable connectors currently limits the usability and translation of these approaches into medical devices for clinical use worldwide. Optoelectronic probes for optogenetic applications face similar challenges [92]. Thermal management of implanted light sources, their hermetic packaging and the transparency of waveguides are current bottlenecks [93] for long-term application.…”

Section: E Stability and Functionality Of Flexible Electrodesmentioning

confidence: 99%

Developing Next-Generation Brain Sensing Technologies—A Review

et al. 2019

View full text Add to dashboard Cite

Advances in sensing technology raise the possibility of creating neural interfaces that can more effectively restore or repair neural function and reveal fundamental properties of neural information processing. To realize the potential of these bioelectronic devices, it is necessary to understand the capabilities of emerging technologies and identify the best strategies to translate these technologies into products and therapies that will improve the lives of patients with neurological and other disorders. Here, we discuss emerging technologies for sensing brain activity, anticipated challenges for translation, and perspectives for how to best transition these technologies from academic research labs to useful products for neuroscience researchers and human patients.

show abstract

Section: E Stability and Functionality Of Flexible Electrodesmentioning

confidence: 99%

Developing Next-Generation Brain Sensing Technologies—A Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Some design concepts that work well for short term application might lack sufficient long-term stability. Water uptake and permeability of ions contributes to short circuits in integrated electronic circuits and components [32,33] and eventually leads to implant failure. An overview of the main components and modules is given highlighting strengths and weaknesses of different opportunities.…”

Section: Technical Components Of Neurotechnological Implantsmentioning

confidence: 99%

Why Neurotechnologies? About the Purposes, Opportunities and Limitations of Neurotechnologies in Clinical Applications

Stieglitz

2019

Neuroethics

View full text Add to dashboard Cite

Neurotechnologies describe a field of science and engineering in which the nervous system is interfaced with technical devices. Fundamental research is conducted to explore functions of the brain, decipher the neural code and get a better understanding of diseases and disorders. Risk benefit assessment has been well established in all medical disciplines to treat patients best possible while minimizing jeopardizing their lives by the interventions. Is this set of assessment rules sufficient when the brain will be interfaced with a technical system and is this assessment enough? How will these new technologies change personality and society? This article will shortly review different stakeholders' opinions and their expectation in the field, assembles information the state-of-the art in medical applications of neurotechnological implants and describes and assesses the fundamental technologies that are used to build up these implants starting with essential requirements of technical materials in contact with living tissue. The different paragraphs guide the reader through the main aspects of neurotechnologies and lay a foundation of knowledge to be able to contribute to the discussion in which cases implants will be beneficial and in which cases we should express serious concerns.

show abstract

“…Optogenetics, a neuromodulation method that exploits the use of visible light to control living neurons that have been genetically modified to express light-sensitive ion channels, deserves mentioning [ 33 , 34 ]. The performance of optoelectronic microprobes has been enhanced, in both acute and chronic implantations, by adopting nanomaterials whose properties (i.e., spatial resolution, interactions with the target tissue, etc.)…”

Section: Theranosticsmentioning

confidence: 99%

Understanding the Pathological Basis of Neurological Diseases Through Diagnostic Platforms Based on Innovations in Biomedical Engineering: New Concepts and Theranostics Perspectives

et al. 2018

View full text Add to dashboard Cite

The pace of advancement of genomics and proteomics together with the recent understanding of the molecular basis behind rare diseases could lead in the near future to significant advances in the diagnosing and treating of many pathological conditions. Innovative diagnostic platforms based on biomedical engineering (microdialysis and proteomics, biochip analysis, non-invasive impedance spectroscopy, etc.) are introduced at a rapid speed in clinical practice: this article primarily aims to highlight how such platforms will advance our understanding of the pathological basis of neurological diseases. An overview of the clinical challenges and regulatory hurdles facing the introduction of such platforms in clinical practice, as well as their potential impact on patient management, will complement the discussion on foreseeable theranostic perspectives. Indeed, the techniques outlined in this article are revolutionizing how we (1) identify biomarkers that better define the diagnostic criteria of any given disease, (2) develop research models, and (3) exploit the externalities coming from innovative pharmacological protocols (i.e., those based on monoclonal antibodies, nanodrugs, etc.) meant to tackle the molecular cascade so far identified.

show abstract

Integrated optoelectronic microprobes

Cited by 19 publications

References 40 publications

Developing Next-Generation Brain Sensing Technologies—A Review

Developing Next-Generation Brain Sensing Technologies—A Review

Why Neurotechnologies? About the Purposes, Opportunities and Limitations of Neurotechnologies in Clinical Applications

Understanding the Pathological Basis of Neurological Diseases Through Diagnostic Platforms Based on Innovations in Biomedical Engineering: New Concepts and Theranostics Perspectives

Contact Info

Product

Resources

About