Clove Bud Polyphenols Alleviate Alterations in Inflammation and Oxidative Stress Markers Associated with Binge Drinking: A Randomized Double-Blinded Placebo-Controlled Crossover Study

Mammen, Renny R.; Mulakal, Johannah Natinga; Mohanan, Ratheesh; Maliakel, Balu; Krishnakumar, I. M.

doi:10.1089/jmf.2017.4177

Cited by 23 publications

(39 citation statements)

References 22 publications

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“…However, there were also differences. For example, whereas Kim et al [ 22 ] found a significant correlation between Il-6 and hangover severity, this correlation did not reach significance in the study by Mammen et al [ 23 ]. Other studies also reported no significant correlation between IL-6 concentration and hangover severity [ 10 , 14 ].…”

Section: Discussionmentioning

confidence: 86%

“…Data from two studies were re-evaluated (see original articles for details on methodology) [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…In a second double-blind crossover study, Mammen et al [ 23 ] examined the effect of a polyphenolic extract of clove buds (Clovinol) versus placebo on hangover severity in n = 16 healthy men (mean ± SD age of 29.5 ± 6.2 years old). The study was conducted in India, and genetic polymorphisms in alcohol metabolic enzymes were not considered.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the aim of the current article was to further investigate and integrate data on alcohol metabolism, oxidative stress and the inflammatory response to alcohol consumption in relation to alcohol hangover. To this extent, we re-evaluated data from the two available studies that collected this combined data in the same subjects, enabling a direct investigation into their interrelationships [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover

Loo

Mackus

Kwon

et al. 2020

JCM

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An increasing number of studies are focusing on the inflammatory response to alcohol as a potentially important determinant of hangover severity. In this article, data from two studies were re-evaluated to investigate the relationship between hangover severity and relevant biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol. Hangover severity was significantly and positively correlated with blood concentrations of biomarkers of the inflammatory response to alcohol, in particular, Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein (CRP). At 4 h after alcohol consumption, blood ethanol concentration (but not acetaldehyde) was significantly and positively associated with elevated levels of IL-6, suggesting a direct inflammatory effect of ethanol. In addition, biomarkers of oxidative stress, i.e., malondialdehyde and 8-isoprostrane, were significantly correlated with hangover severity, suggesting that oxidative stress also contributes to the inflammatory response. The timing of the assessments suggests initial slow elimination of ethanol in the first hours after alcohol consumption. As a consequence, more ethanol is present in the second half of the night and the next morning, which will elicit more oxidative stress and a more profound inflammatory response. Together, these processes result in more severe hangovers.

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Section: Discussionmentioning

confidence: 86%

“…Data from two studies were re-evaluated (see original articles for details on methodology) [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover

Loo

Mackus

Kwon

et al. 2020

JCM

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“…In addition, it has been clearly indicated that antioxidant effect of clove is in good correlation with polyphenols content [14]. Furthermore, antioxidant activity of clove extract has been described in several in vitro or in vivo studies [15,16]. On the other hand, although polyphenols are considered antioxidants, some experimental results indicate a possible pro-oxidant effect of these phytochemicals [17,18].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells

et al. 2020

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In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. The main mechanisms of spices action included apoptosis induction, proliferation, migration and invasion of tumour inhibition, and sensitization of tumours to radiotherapy and chemotherapy. In this study, the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation were analysed in MCF-7 cells. We demonstrated that CBE treatment induced intrinsic caspase-dependent cell death associated with increased oxidative stress mediated by oxygen and nitrogen radicals. We showed also the CBE-mediated release of mitochondrial pro-apoptotic factors, signalling of oxidative stress-mediated DNA damage with modulation of cell antioxidant SOD (superoxide dismutase) system, and modulation activity of the Akt, p38 MAPK, JNK and Erk 1/2 pathways.

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Effect of alcohol on blood pressure

Tasnim

Tang

Musini

et al. 2020

Cochrane Database of Systematic Reviews

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Clove Bud Polyphenols Alleviate Alterations in Inflammation and Oxidative Stress Markers Associated with Binge Drinking: A Randomized Double-Blinded Placebo-Controlled Crossover Study

Cited by 23 publications

References 22 publications

The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover

The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover

Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells

Effect of alcohol on blood pressure

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