Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

Gallagher, Grant; Dickensheets, Harold; Eskdale, Joyce; Ls, Izotova; Mirochnitchenko, OV; Peat, JD; Vázquez, Nancy; Pestka, Sidney; Donnelly, R P; Kotenko, S.V.

doi:10.1038/sj.gene.6363714

Cited by 275 publications

(229 citation statements)

References 63 publications

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“…Three genes belonging to the IL10 family (IL19, IL20 and IL24) have been recently mapped immediately telomeric to IL10 at a distance of 60 , 82 and 112 kb respectively from IL10G, and are possible candidates. [36][37][38] However, could it be that the IL10.G microsatellite itself rather than some other variation in linkage disequilibrium with it is involved in SLE genetic susceptibility? At first sight this hypothesis seems unlikely since three different alleles were increased in three different IL10.G/SLE association studies.…”

Section: Discussionmentioning

confidence: 99%

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

et al. 2002

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Many lines of evidence suggest that IL10 is a strong candidate gene for systemic lupus erythematosus (SLE) susceptibility. In our previously reported study an allele (IL10.G-140bp) of the microsatellite IL10.G located at position À1100 was significantly increased in Italian SLE patients in comparison with controls. Starting from this observation, we tested if sequence variations in the vicinity of IL10.G were more strongly associated with SLE. We performed a comprehensive association study including 26 SNPs (of which four were newly identified in the present study by DHPLC analysis) spanning 8.5 Kb of the 5 0 flanking and the transcribed region of the IL10 gene. The association study was performed by the DNA pool method on an extended panel of Italian patients (205) and controls (631). Haplotypic associations were studied by individual typing of seven selected markers surrounding IL10.G. Gene, genotype and haplotype frequencies were not significantly different in patients and controls. Thus the IL10.G microsatellite remains to date the only IL10 marker associated with SLE in our population. A meta-analysis of all published results indicates a possible direct role of the IL10.G repeat number in SLE susceptibiliy.

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Section: Discussionmentioning

confidence: 99%

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

et al. 2002

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“…5,6 IL-19 and -20 are members of the IL-10 family that were initially identified during a sequence database search aimed to find potential IL-10 homologs. 6,7 has been found to be preferentially expressed in monocytes and its main targets are keratinocytes, where IL-20 binds type I IL-20R (IL-20Ra and -20Rb) and type II IL-20R (IL-20Rb and -22R) complexes. 6,8,9 Binding of the IL-20 in human HaCaT keratinocytic cell line results in STAT 3 phosphorylation and activation of a promoter including STAT-binding sites.…”

Section: Introductionmentioning

confidence: 99%

“…IL-19 has been detected in immune cells, such as LPS-or GM-CSF-activated and resting monocytes, and at lower level in resting and stimulated B cells. 7,8 This cytokine binds to the type I IL-20R complex and modulates gene expression in responsive cell types through activation of the STAT 1 and STAT 3 signal transduction pathway. [9][10][11] Sharing the same receptor complex with IL-20 suggests that IL-19 may have partially overlapping biological activities with IL-20.…”

Section: Introductionmentioning

confidence: 99%

“…6,7,14,15 Linkage to several common autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, have been detected in this locus. [16][17][18] In addition, protective effect of microsatellite marker IL-10.G9 allele 3 for familial psoriasis has been observed using the transmission/ disequilibrium test (TDT) in persons with a positive family history of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis

et al. 2004

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“…[1][2][3][4][5][6][7] IL-24 shows limited but significant homology to the cytokines of this family, and shares the highest aminoacid identity (33%) with IL-20. 7 Expression of IL-24 was detected in spleen, thymus, 8 melanocytes, 9 ConA activated human PBMC cells, 10 LPS-treated monocytes and anti-CD3-treated T cells.…”

Section: Introductionmentioning

confidence: 99%

Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24

et al. 2004

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IL-24/MDA-7 is a new member of the IL-10 family of cytokines, which signals through two heterodimeric receptor complexes (IL-20R1/IL-20R2 and IL-22R/IL-20R2). Previously, we identified a rat gene named mob-5, which encodes a secreted protein that shares a high degree of homology with human IL-24. Expression of mob-5 and its putative cell surface receptors was shown to be upregulated by oncogenic ras. Here we show that not only do rat mob-5 and human IL-24 share a strikingly similar genomic structure but also that the rat MOB-5 protein can bind to and signal through the human IL-24 receptors. Like human IL-24, binding of the rat MOB-5 protein to the human IL-24 receptors leads to activation of the JAK/STAT pathway, which in turn supports receptor-dependent survival and proliferation of Ba/F3 cells. Furthermore, using human colon cancer cell lines with somatic knockout of either the mutant or the wild-type k-ras allele, we demonstrate that the human IL-24 receptors also are upregulated by oncogenic ras. Taken together, these results provide strong experimental evidence that MOB-5 is indeed the rat homolog of human IL-24.

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Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

Cited by 275 publications

References 63 publications

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5′ regulatory region

Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis

Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24

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